
Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin
Keywords: Hp, heparin; cGMP, current good manufacturing practices; NSNAH, N-sulfo heparosan (NSH), N-sulfo, N-acetyl heparosan; NSNA2SHp, N-sulfo, N-acetyl, 2-O-sulfoheparin; C5-epi, C5-epimerase; 2OST, 2-O-sulfotransferase; AST-IV, arylsulfotransferase IV; NACHp,