FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model
Keywords: Bile acid; Fatty liver; Hrn; CYP450-reductase; FXR;
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A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice
Keywords: HRN; Midazolam; ABT; In vivo; In vitroCYPs, cytochrome P450 enzymes; HRN, hepatic reductase null; WT, wild type (C57Bl/6J); ABT, 1′-aminobenzotriazole; HPMC, hydroxypropyl methylcellulose; DMSO, dimethyl sulfoxide; GI, gastrointestinal tract; QC, quality
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I
Keywords: AHR; aryl hydrocarbon receptor; AA; aristolochic acid; AAI; aristolochic acid I; AAIa; aristolochic acid Ia; AAN; aristolochic acid nephropathy; ARE; antioxidant response element (also known as EpRE, electrophile response element); BEN; Balkan endemic nep
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
Keywords: DTT; dithiothreitol; HLM; human liver microsomes; HRN; Hepatic Reductase Null mouse; POR; NADPH-P450 oxidoreductase; RLM; rat liver microsomes; WT; wild type; Antitumour agents; Capridine β; C-1748; Hypoxia; Metabolism; 1-Nitroacridines;
Research ArticleInsulin resistance predicts re-treatment failure in an efficacy study of peginterferon-α-2a and ribavirin in HIV/HCV co-infected patients
Keywords: HIV; human immunodeficiency virus; HCV; hepatitis C virus; HRN; hepatitis Resource Network; HCV RNA; hepatitis C virus ribonucleic acid; HOMA-IR; homeostasis model of assessment of insulin resistance; AOR; adjusted odds ratio; CI; confidence interval; HCC
Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
Keywords: COX; cyclooxygenase; CYP; cytochrome P450; HRN; hepatic cytochrome P450 reductase null; GAPDH; glyceraldehyde phosphate dehydrogenase; HPLC; high-performance liquid chromatography; i.p.; intra-peritoneal; LPO; lactoperoxidase; MPO; myeloperoxidase; PEI-ce
Recommandations pour le diagnostic et la prise en charge de la rhinite allergique (épidémiologie et physiopathologie exclues) - Texte long
Keywords: AINS; Anti-Inflammatoire Non Stéroïdien; ARIA; Allergic Rhinitis and its Impact on Asthma; DNS; Dysfonctionnement Naso-Sinusien; EFR; Ãpreuves Fonctionnelles Respiratoires; EMEA; European Medicines Evaluation Agency (Agence Européenne d'Evaluation d
Recommandations pour le diagnostic et la prise en charge de la rhinite allergique (épidémiologie et physiopathologie exclues) - Texte long
Keywords: AINS; Anti-Inflammatoire Non Stéroïdien; ARIA; Allergic Rhinitis and its Impact on Asthma; DNS; Dysfonctionnement Naso-Sinusien; EFR; Ãpreuves Fonctionnelles Respiratoires; EMEA; European Medicines Evaluation Agency (Agence Européenne d'Evaluation d