Keywords: HSCs، سلول های ستون فقرات کبدی; T2DM, type 2 diabetes mellitus; CVD, cardiovascular disease; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; HSCs, hepatic stellate cells; ER, endoplasmic reticulum; UPR, unfolded protein response; MCD, methionine- and choline
مقالات ISI HSCs، سلول های ستون فقرات کبدی (ترجمه نشده)
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Keywords: HSCs، سلول های ستون فقرات کبدی; CCB, calcium channel blocker; HSCs, hepatic stellate cells; DFO, deferoxamine; Tf, transferrin; TfR, transmembrane transferrin receptor; Ft, ferritin; LVDCCs, L-type voltage-dependent calcium channels; DMT-1, divalent metal transporter-1; ECM, extracellul
Keywords: HSCs، سلول های ستون فقرات کبدی; NAFLD, non-alcoholic fatty liver disease; TG, triglycerides; NASH, non-alcoholic steatohepatitis; HSCs, hepatic stellate cells; alpha-SMA, smooth muscle alpha-actin; IL-8, interleukin-8; TNF-alpha, tumor necrosis alpha; TGF-beta1, transforming growth fact
Keywords: HSCs، سلول های ستون فقرات کبدی; BDECs, Bile duct epithelial cells; CBDL, Common bile duct ligation; CCl4, Carbon tetrachloride; FCH, Fibrosing cholestatic hepatitis; HSCs, Hepatic stellate cells; LECs, Liver endothelial cells; TBIL, Total bilirubin; VEGF, Vascular endothelial growth fac
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; TQ, thymoquinone; NASH, nonalcoholic steatohepatitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; CBDL, common bile duct ligation; LPS, lipopolysaccharide; CCl4, carbon tetrachl
Keywords: HSCs، سلول های ستون فقرات کبدی; α-SMA, alpha smooth muscle actin; CCl4, carbon tetrachloride; HSCs, hepatic stellate cells; IFNγ, interferon gamma; mimIFNγ, interferon gamma peptidomimetic; MHC-II, major histocompatibility complex-II; TIMP-1, tissue inhibitor of matrix metalloproteinase
Keywords: HSCs، سلول های ستون فقرات کبدی; ACEi, ACE inhibitors; AT1 ARBs, blockers; CDAA, choline-deficient l-amino acid-defined; DMN, dimethyl nitrosamine; ECM, extracellular matrix; ERK, extracellular-signal-regulated kinases; HSCs, hepatic stellate cells; ac-HSC, HSCsfrom quiescent to activate
Keywords: HSCs، سلول های ستون فقرات کبدی; Nanoprobe; Hepatic stellate cells; Integrin αvβ3; Liver fibrosis; MRI modalityCLD, Chronic liver diseases; ECM, extracellular matrix; HSCs, hepatic stellate cells; RGD, arginine-glycine-aspartic acid; cRGDyK, cyclo[Arg-Gly-Asp-(D)Tyr-Lys]; MRI, magnetic r
Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection
Keywords: HSCs، سلول های ستون فقرات کبدی; Ad, adenovirus; APCs, antigen-presenting cells; CTL, cytotoxic T lymphocyte; DAMP, damage associated molecule pattern; DCs, dendritic cells; Gal-9, galectin-9; γδ T, gamma delta T; HSCs, hepatic stellate cells; iNKT, invariant NKT; IFNs, interferons; IFN-
Cellular distribution of injected PLGA-nanoparticles in the liver
Keywords: HSCs، سلول های ستون فقرات کبدی; PLGA, Poly (D,L-lactide-co-glycolide); NPs, nanoparticles; LSECs, liver sinusoidal endothelial cells; HSCs, hepatic stellate cells; DiD, 1,1′-Dioctadecyl-3,3,3′,3′-Tetramethylindodicarbocyanine,4 Chlorobenzenesulfonate Salt; DCM, dichloromethane; PVA, pol
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; Sirt1, Sirtuin 1; CCl4, carbon tetrachloride; BDL, bile duct ligation; DMN, dimethylnitrosamine; HO-1, heme oxygenase-1; GST, glutathione-S-transferase; GCLC, glutathione cysteine ligase catalytic subunit; GCLM, glutathione c
Activation of Slit2-Robo1 signaling promotes liver fibrosis
Keywords: HSCs، سلول های ستون فقرات کبدی; α-SMA, α-smooth muscle actin; CCl4, carbon tetrachloride; ECM, extracellular matrix; HSCs, hepatic stellate cells; Robo1/2+/− mice, Robo1+/−Robo2+/− double heterozygotes mice; Slit2-Tg mice, Slit2-transgenic mice; TGF-β1, transforming growth factor-βα-SMA
Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction
Keywords: HSCs، سلول های ستون فقرات کبدی; ADH, alcohol dehydrogenase; ALT, alanine transaminase; AST, aspartate transaminase; CYP2E1, cytochrome P4502E1; DEN, diethylnitrosamine; FFA, free fatty acids; HCC, hepatocellular carcinoma; HSCs, hepatic stellate cells; MPTP, mitochondrial permeability t
Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway
Keywords: HSCs، سلول های ستون فقرات کبدی; HDN, hesperidin; HDND-7, 4′-methoxy-8-methyl-(n-ethylpiperazine)-3′,5,7-trihydroxyflavanone; HSCs, hepatic stellate cells; α-SMA, α-smooth muscle actin; Col1a1, type I collagen alpha-1; ECM, extracellular matrix; PDGF, platelet-derived growth factor; TGF-
Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats
Keywords: HSCs، سلول های ستون فقرات کبدی; ECM, extracellular matrix; HSCs, Hepatic stellate cells; α-SMA, smooth muscle α-actin; SATB1, special AT-rich binding protein-1; MARs, matrix attachment regions; EMT, epithelial–mesenchymal transition; TAA, thioacetamide; FBS, fetal bovine serum; MOI, mul
Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
Keywords: HSCs، سلول های ستون فقرات کبدی; SIRT1, silent information regulator 1; ECM, extracellular matrix; HSCs, hepatic stellate cells; α-SMA, α-smooth muscle actin; Col1a1, type I collagen; TGF-β1, transforming growth factor-β1; PGC1-α, peroxisome proliferator-activated receptor-γ co-activator
Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1–AMPK signaling pathway in mice
Keywords: HSCs، سلول های ستون فقرات کبدی; α-SMA, α-smooth muscle actin; Akt, threonine kinase-protein kinase B; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AMPK, adenosine monophosphate-activated protein kinase; ECM, extracellular matrix; HSCs, hepatic stellate cells; IL, inte
Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis
Keywords: HSCs، سلول های ستون فقرات کبدی; ECM, extracellular matrix; HSCs, hepatic stellate cells; TGF-β1, transforming growth factor-β1; Col 1, collagen I; α-SMA, α-smooth muscle actin; Stat3, signal transducer and activator of transcription 3; Jak, Janus tyrosine kinase; GH, growth hormone; CHB
Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation
Keywords: HSCs، سلول های ستون فقرات کبدی; BMP-4, bone morphogenetic protein-4; TGF-β, transforming growth factor-β; GDFs, growth differentiation factors; ALK, activin receptor-like kinase; MAPKs, mitogen-activated protein kinases; HSCs, hepatic stellate cells; ECM, extracellular matrix; α-SMA, sm
Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4−/− mice
Keywords: HSCs، سلول های ستون فقرات کبدی; Abcb4−/−, ATP-binding cassette, sub-family B member 4; ECM, extracellular matrix; F4/80, EGF-like module containing, mucin-like, hormone receptor-like sequence 1; HSCs, hepatic stellate cells; α-SMA, actin, alpha 2, smooth muscle; tPA, tissue-type plasmin
Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies
Keywords: HSCs، سلول های ستون فقرات کبدی; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; HSCs, hepatic stellate cells; EMT, epithelial to mesenchymal transition; ECM, extracellular matrix; LPS, lipopolysaccharide; TLRs, Toll-like receptors; TIR, Toll/IL-1 receptor; P
Antifibrotic effects of glycyrrhizin and matrine in vitro and in vivo
Keywords: HSCs، سلول های ستون فقرات کبدی; Glycyrrhizin; Matrine; HSC-T6 cell; Carbon tetrachloride; Hepatic fibrosis; Rat modelMat, Matrine; Gly, Glycyrrhizin; ECM, Extracellular matrix; HSCs, Hepatic stellate cells; CCL4, Carbon tetrachloride; HA, Hexadecenoic acid; LN, Laminin; PC-III, Procollg
Dietary protein restriction induces steatohepatitis and alters leptin/signal transducers and activators of transcription 3 signaling in lactating rats
Keywords: HSCs، سلول های ستون فقرات کبدی; PR, protein restriction; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; AMPK, 5′-adenosine monophosphate-activated protein kinase; VLDL, very-low-density lipoprotein; HSCs, hepatic stellate cells; NADPH, nicotinamide adenine
α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; ROS, reactive oxygen species; α-SMA, α-smooth muscle actin; PDGF, platelet-derived growth factor; TGF-β, transforming growth factor-β; LAα-, lipoic acid; DHLA, dihydrolipoic acid; MAPK, mitogen-activated protein kinase; ERK,
Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; RT-PCR, reverse transcription polymerase chain reaction; α-Sma, α-smooth muscle actin; Dkk, Dickkopf; Fzd, Frizzled; LRP, low density lipoprotein receptor-related protein; Lef/Tcf, lymphoid enhancer-binding factor/transcripti
Albumin expression is required for adipocyte differentiation of 3T3-L1 cells
Keywords: HSCs، سلول های ستون فقرات کبدی; C/EBP, CCAAT/enhancer-binding protein; PPAR-γ, peroxisome proliferator-activated receptor-γ; shRNA, short-hairpin RNA; HSCs, hepatic stellate cells; α-SMA, α-smooth muscle actin; NAR, Nagase analbuminemic ratsAlbumin; 3T3-L1 adipocyte; Lipid droplet forma
In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis
Keywords: HSCs، سلول های ستون فقرات کبدی; RA, rosmarinic acid; TGF-β1, transforming growth factor-β1; CTGF, connective transforming growth factor; HSCs, hepatic stellate cells; α-SMA, α-smooth muscle actin; CCL4, carbon tetrachloride; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine se
Congenital exposure to Schistosoma mansoni infection: Impact on the future immune response and the disease outcome
Keywords: HSCs، سلول های ستون فقرات کبدی; BSA, bovine serum albumin; GFAP, glial fibrillary acidic protein; HRP, horseradish peroxidase; HSCs, hepatic stellate cells; IL-12, interleukin-12; MoAb, monoclonal antibody; p.i., post-infection; PBS, phosphate buffered saline; RT-PCR, reverse transcript
The inhibitory effect of Gynostemma pentaphyllum on MCP-1 and type I procollagen expression in rat hepatic stellate cells
Keywords: HSCs، سلول های ستون فقرات کبدی; CINC-2, cytokine-induced neutrophil chemoattractant-2; CNTF, ciliary neurotrophic factor; GCSF, granulocyte-colony stimulating factor; HSCs, hepatic stellate cells; LIX, LPS induced C-X-C chemokine; MCP-1, monocyte chemoattractant protein-1; MIP-3α, macro
Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation
Keywords: HSCs، سلول های ستون فقرات کبدی; α-SMA, α-smooth muscle actin; BrdU, bromodeoxyuridine; HSCs, hepatic stellate cells; LI, labeling index; miRNA, microRNA; MRE, microRNA recognition element; RXRα, retinoid X receptor α; 3′UTR, 3′untranslated regionMicroRNA-27; Hepatic stellate cell; Fat a
A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells
Keywords: HSCs، سلول های ستون فقرات کبدی; ECM, extracellular matrix; HSCs, hepatic stellate cells; hTERT, human telomerase reverse transcriptase; IL, interleukin; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MCP1, monocyte chemotactic protein 1; MD2, myeloid differentiation 2; RANTES, r
Alcohol induced hepatic fibrosis: Role of acetaldehyde
Keywords: HSCs، سلول های ستون فقرات کبدی; ALD, alcoholic liver disease; Ac CHO, acetaldehyde; ADH, alcohol dehydrogenase enzyme; ALDH, acetaldehyde dehydrogenase; MEOS, microsomal ethanol-oxidizing system; ROS, reactive oxygen species; HSCs, hepatic stellate cells; PPARγ, peroxisome proliferator-
The molecular mechanism of gypenosides-induced G1 growth arrest of rat hepatic stellate cells
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; PI3K, phosphatidylinositol 3-kinase; p70S6K, 70-kDa ribosomal S6 kinase; PDGF, platelet-derived growth factor; MEK, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase; MAPK, mitogen-activated protei
Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis
Keywords: HSCs، سلول های ستون فقرات کبدی; α-SMA, α-smooth muscle actin; ALT, alanine aminotransferase; CCl4, carbon tetrachloride; COL1A2, collagen type 1 α 2; HCV, hepatitis C viral; HSCs, hepatic stellate cells; IFN-γ, interferon-γ; IRF-1, interferon regulatory factor 1; JAK, Janus kinase; MNC,
Loss of TGF-β dependent growth control during HSC transdifferentiation
Keywords: HSCs، سلول های ستون فقرات کبدی; BDL, bile duct ligation; ECM, extracellular matrix; HGF, hepatocyte growth factor; HSCs, hepatic stellate cells; Il, interleukin; LPS, lipopolysaccharide; MFBs, myofibroblasts; OSM, oncostatin M; PDGF, platelet-derived growth factor; TGF, transforming gro
Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-β signaling pathway
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; TGF-β1, transforming growth factor-β1; ECM, extracellular matrix; MMP, metalloproteinase; TIMP, tissue inhibitor of metalloproteinaseHypoxia; Hepatic stellate cells; Fibrogenesis
Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat
Keywords: HSCs، سلول های ستون فقرات کبدی; Dalteparin sodium; Hepatocyte growth factor (HGF); Platelet-derived growth factor (PDGF); Hepatic stellate cells; Hepatic regeneration; Liver fibrosisBrdU, 5-Bromo-2′-deoxyuridine; HSCs, hepatic stellate cells; HGF, hepatocyte growth factor; 4-HNE, 4-hydr
Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C
Keywords: HSCs، سلول های ستون فقرات کبدی; TN-C, tenascin-C; α-SMA, α-smooth muscle actin; PDGF-BB, platelet-derived growth factor-BB; HSCs, hepatic stellate cells; FNIII, fibronectin type III-like; EGFL, epidermal growth factor-like; TGF-β, transforming growth factor-βTenascin-C; Splice variants;
Expression and upregulation of cathepsin S and other early molecules required for antigen presentation in activated hepatic stellate cells upon IFN-γ treatment
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; CIITA, class II transactivator; IFN-γ, interferon gamma; LSEC, liver sinusoidal endothelial cells; DC, dendritic cells; APCs, antigen presenting cells; CLIP, class II associated li-peptide; AFC, 7-amino-4-trifluoromethyl coum
Effects of rhDecorin on TGF-β1 induced human hepatic stellate cells LX-2 activation
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; TGF-β1, transforming growth factor-β1; ECM, extracellular matrix; MMP, metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; α-SMA, smooth muscle-α-actinDecorin; Hepatic stellate cell; LX-2 cell line; Fibrogenesis;
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
Keywords: HSCs، سلول های ستون فقرات کبدی; HSCs, hepatic stellate cells; ECM, extracellular matrix; Bmp, bone morphogenic protein; FBS, fetal bovine serumLiver fibrosis; Hepatic stellate cells; DNA microarray; Gene expression
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells
Keywords: HSCs، سلول های ستون فقرات کبدی; ECM, extracellular matrix; HSCs, hepatic stellate cells; IκB-α, IkappaB-α; MAPK, mitogen activated protein kinase; MMP, matrix metalloproteinases; SEAP, secretory alkaline phosphatase; SNAP, S-nitroso-N-acetyl-dl-penicillamine; SIN-1, N-morpholino sydnoni