Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor
Keywords: HTS, high-throughput screen; FXR, farnesoid X receptor; NRs, nuclear receptors; Cyp7A1, cytochrome 7A1; BAs, bile acids; BSEP, bile salt export pump; SAR, structure–activity relationship; LBD, ligand-binding domain