دانلود مقالات ISI درباره HTS، غربالگری بالا + ترجمه فارسی

شناسایی مهارکننده های پروتئینی تریروزین فسفاتاز جدید پروتئین های پیشرفته نوریت

Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension

Keywords: HTS، غربالگری بالا; PTPσ, protein tyrosine phosphatase sigma; CSPG, chondroitin sulfate proteoglycan; PTP, protein tyrosine phosphatase; HSPG, heparan sulfate proteoglycan; IC50, half-maximal inhibitory concentration; HTS, high-throughput screening; KCB, Korea Chemical Bank;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

طراحی پروب های کروموژنیک برای غربالگری کارآمد و ارزیابی فعالیت های فرولوییل استراز مانند

Design of chromogenic probes for efficient screening and evaluation of feruloyl esterase-like activities

Keywords: HTS، غربالگری بالا; BI-Co, 5-bromoindol-3-yl coumarate; CinnAE, cinnamoyl esterase; CSA, camphor sulphonic acid; DIPC, N,N′-diisopropylcarbodiimide; DMAP, 4-(dimethylamino)pyridine; FAE, feruloyl esterase; GH, glycoside hydrolase; HTS, high-throughput screening; 4NTC, 4-nitr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

یک آزمایش بیولوژیک برای اندازه گیری جذب گلوکز

A bioluminescent assay for measuring glucose uptake

Keywords: HTS، غربالگری بالا; Bioluminescent; Glucose uptake2DG, 2-deoxyglucose; 2DG6P, 2-deoxyglucose-6-phosphate; NADP(H), nicotinamide adenine dinucleotide phosphate; G6PDH, glucose-6-phosphate dehydrogenase; DTNB, 5,5'-dithiobis-2-nitrobenzoic acid; HTS, high-throughput screening;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

آزمایش غربالگری با توان بالا مبتنی بر HTRF برای کشف ترکیبات شیمیایی که مانع از تعامل بین Trypanosoma brucei Pex5p و Pex14p می شود

An HTRF based high-throughput screening for discovering chemical compounds that inhibit the interaction between Trypanosoma brucei Pex5p and Pex14p

Keywords: HTS، غربالگری بالا; HTRF, homogenous time-resolved fluorescence; PTS-1, peroxisome-targeting signal type-1; GST, glutathione S-transferase; HTS, high-throughput screening; FRET, fluorescence resonance energy transferTrypanosome; Glycosome; Pex5p; Pex14p; Homogenous time-reso

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

A novel cell-based duplex high-throughput screening assay combining fluorescent Ca2+ measurement with homogeneous time-resolved fluorescence technology

Keywords: HTS، غربالگری بالا; Cell-based assays; High-throughput screening; Multiplex assays and technology; Fluorescent Ca2+ measurement; HTRF technologyGPCR, G-protein-coupled receptor; HTS, high-throughput screening; HCS, high-content screening; FRET, fluorescence resonance energy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase

Keywords: HTS، غربالگری بالا; H-PGDS; High-throughput screening; Inhibitor; SPACOX, cyclooxygenase; DTT, dithiothreitol; GST, glutathione S-transferase; H-PGDS, hematopoietic prostaglandin D2 synthase; HTS, high-throughput screening; L-PGDS, lipocalin-type prostaglandin D2 synthase; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A real-time, fluorescence-based assay for Rho-associated protein kinase activity

Keywords: HTS، غربالگری بالا; Kinase activity assay; Fluorescence-based biosensor; Rho-associated protein kinase; Inhibition; Small molecule screeningROCK, rho-associated protein kinase; HCC, hepatocellular carcinoma; HTS, high-throughput screening; CHEF, chelation-enhanced fluorescen

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor

Keywords: HTS، غربالگری بالا; Aurora B; Kinase inhibitor; Tumor growth; Molecular targeted chemotherapySPR, surface plasmon resonance; IC50, half maximal inhibitory concentration; RT, room temperature; HTS, high-throughput screening; OD, optical density; P–H3, phosphorylated histone H

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Drugging the undruggable: Transcription therapy for cancer

Keywords: HTS، غربالگری بالا; AR, androgen receptor; DHFR, dihydrofolate reductase; DNMT, DNA methyltransferase; ER, estrogen receptor; HDAC, histone deacetylase; HMT, histone methyltransferase; HTS, high-throughput screening; MDR1, multidrug resistance protein 1; ODN, oligodeoxynucle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular docking of γ-sitosterol with some targets related to diabetes

Keywords: HTS، غربالگری بالا; γ-Sitosterol; Lippia nodiflora; Docking analysis; Diabetes mellitusADME/T, Absorption, distribution, metabolism, excretion and toxicity; HTS, High-throughput screening; ADT, Autodock tool; STZ, Streptozotocin; AST, Aspartate transaminase; ALT, Alanine tra

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization

Keywords: HTS، غربالگری بالا; Casein kinase 1; Pharmacophore; Virtual screening; Lead optimization; Cancer; Central nervous system disordersCK1, casein kinase 1; VS, virtual screening; HTS, high-throughput screening; QSAR, quantitative structure–activity relationship; PDB, protein dat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Application of genetic algorithms and response surface analysis for the optimization of batch chromatographic systems

Keywords: HTS، غربالگری بالا; CCI, central composite inscribed design; CV, column volume; DoE, design of experiments; Eij, elution step i fraction j; GA, genetic algorithm; HTS, high-throughput screening; HTE, high-throughput experiments; L, load step; lhs, liquid handling station; LH

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method

Keywords: HTS، غربالگری بالا; CBRI, Chemical Biology Research Initiative University of Tokyo; Cyp, cyclophilin; DMEM, Dulbecco’s modified Eagle’s medium; FCS, fetal calf serum; FKBP, FK-506 binding protein; GST, glutathione S-transferase; HTS, high-throughput screening; MCA, 4-methylc

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC

Keywords: HTS، غربالگری بالا; SCD, stearoyl-CoA desaturase; C18:0, stearoyl-CoA; C16:0, palmitoyl-CoA; C18:1, oleoyl-CoA; C16:1, palmitoleoyl-CoA; LCFA, long-chain fatty acid; HTS, high-throughput screening; DAG, diacylglycerides; SPE, solid-phase extraction; PEST, penicillin streptom

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Precision in affinity capillary electrophoresis for drug–protein binding studies

Keywords: HTS، غربالگری بالا; ACE, affinity capillary electrophoresis; HSA, human serum albumin; BSA, bovine serum albumin; βLG, β-lactoglobulin; Trp, tryptophan; War, warfarin; Qu, quercetin; Ac, acetanilide; SDS, sodium dodecyl sulphate; HTS, high-throughput screening; RSD, relative

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Identification by high-throughput screening of inhibitors of Schistosomamansoni NAD+ catabolizing enzyme

Keywords: HTS، غربالگری بالا; SmNACE, Schistosomamansoni NAD+ catabolizing enzyme; ε-NAD+, 1,N6-etheno NAD+; HTS, high-throughput screening; PARP, poly(ADP-ribose) polymerase; GPI, glycosylphosphatidylinositolSchistosoma mansoni; SmNACE; CD38; High-throughput screening; Fluorescence;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Strategies for development of dengue virus inhibitors

Keywords: HTS، غربالگری بالا; DENV, dengue virus; WNV, West Nile virus; YFV, yellow fever virus; HCV, hepatitis C virus; HTS, high-throughput screening; RdRp, RNA-dependent RNA polymerase; HIV, human immunodeficiency virus; HSV, herpes simplex virus; UTR, untranslated region; SAR, str

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Functional assays for marine toxins as an alternative, high-throughput-screening solution to animal tests

Keywords: HTS، غربالگری بالا; HPLC, High-performance liquid chromatography; HTS, High-throughput screening; LC-MS, Liquid chromatography mass spectrometry; SPR, surface-plasmon resonance; TEF, Toxicity equivalent factorAnimal test; Ciguatera; Cyclic imine; Detection; Food safety; Func

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1

Keywords: HTS، غربالگری بالا; Imidazotriazine; Polo-like kinase inhibitorPLK, polo-like kinase; SNK, serum-inducible kinase; PRK, proliferation-related kinase; FNK, fibroblast-growth-factor-inducible kinase; SAK, Snk akin kinase; HTS, high-throughput screening; SAR, Structure–activity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

A novel integrin α5β1 antagonistic peptide, A5-1, screened by Protein Chip system as a potent angiogenesis inhibitor

Keywords: HTS، غربالگری بالا; HTS, high-throughput screening; PS-SPCL, positional scanning synthetic peptide combinatorial library; PBST, phosphate-buffered saline containing 0.5% Tween 20; HUVE, human umbilical vein endothelial; CAM, chorioallantoic membrane; MTT, 3-(4,5-dimethylthia

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry

Keywords: HTS، غربالگری بالا; SCD1, stearoyl coenzyme-A desaturase 1; HTS, high-throughput screening; CLA, conjugated linoleic acid; RF-MS, RapidFire Mass Spectrometry; TLC, thin-layer chromatographyStearoyl coenzyme-A desaturase 1; Fatty acid; Desaturase; High-throughput screening; M

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERα ligands and ERRα ligands

Keywords: HTS، غربالگری بالا; AI, aromatase inhibitor; Cou, 3(2′-chlorphenyl)-7-methoxy-4-phenylcoumarin; E2, 17β-estradiol; ER, estrogen receptor; ERE, estrogen responsive element; ERR, estrogen-related receptor; HTS, high-throughput screening; ICI, ICI 182, 780 or Faslodex; T, testo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

A simple high-throughput purification method for hit identification in protein screening

Keywords: HTS، غربالگری بالا; HTS, high-throughput screening; IMAC, immobilized metal affinity chromatography; SEC, size exclusion chromatography; HTRF, homogenous time resolved fluorescence assaysProtein purification; High-throughput purification and screening; scFv

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The flavivirus polymerase as a target for drug discovery

Keywords: HTS، غربالگری بالا; BVDV, bovine viral diarrhea virus; CS, cyclization sequences; DENV, dengue virus; ds, double strand; HCV, hepatitis C virus; HTS, high-throughput screening; MTase, methyltransferase; NI, nucleoside analogue inhibitors; NLS, nuclear localization sequence;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Structure-based discovery of new small molecule inhibitors of low molecular weight protein tyrosine phosphatase

Keywords: HTS، غربالگری بالا; lmwPTP; Phosphatase inhibitors; Docking; Virtual screening; MPA; LINGOADME, absorption, distribution, metabolism and excretion; lmwPTP, low molecular weight protein tyrosine phosphatase; HTS, high-throughput screening; MPA, massive processing algorithm; S

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication

Keywords: HTS، غربالگری بالا; HCV, hepatitis C virus; HMG-CoA, hydroxyl-methyl-glutaryl coenzyme A; HTS, high-throughput screening; PDE, phosphodiesterase; PEG-IFN, pegylated interferon; S/B, signal-to-background; SVR, sustained virologic response

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه