دانلود مقالات ISI درباره HTS، غربالگری بالا + ترجمه فارسی

غربالگری مجازی بر پایه لیگاند برای شناسایی مهار کننده های قوی در مقابل نورامنیداز ویروسی: یک روش رویکرد سیلیکا

Ligand based virtual screening for identifying potent inhibitors against viral neuraminidase: An in silico approach

Keywords: HTS، غربالگری بالا; VS, virtual screening; HTS, high throughput screening; RC, reference compound; NA, neuraminidase; HA, haemagglutinin; ADME/T, Absorption, Distribution, Metabolism, Excretion, and Toxicity; RMSD, root mean square deviation; APOD, abbreviated profile of dru

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

شناسایی اهداف جدید در کارسینوم سلولی کلیه: طراحی و سنتز واکنش های کروماتوگرافی جذب

Identifying novel targets in renal cell carcinoma: Design and synthesis of affinity chromatography reagents

Keywords: HTS، غربالگری بالا; BOC, tert-butyloxycarbonyl; DCM, dichloromethane; DMF, dimethylformamide; HTS, high throughput screening; PAT, pyridylanilino thiazole; PPB, pyridylphenylsulfonyl benzamides; PEG, polyethylene glycol; RCC, renal cell carcinoma; SAR, structure–activity rel

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Selective novel inverse agonists for human GPR43 augment GLP-1 secretion

Keywords: HTS، غربالگری بالا; SCFA, short chain fatty acid; SAR, structure-activity relationship; GPCR, G-protein coupled receptor; hGPR43, human GPR43; mGPR43, mouse GPR43; NF-κB, nuclear factor kappa B; GLP-1, glucagon-like peptide-1; HTS, high throughput screening; DMSO, dimethyl s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

Keywords: HTS، غربالگری بالا; ADHD, Attention Deficit Hyperactive Disorder; ADOS, Autism Diagnosis Observational Scale; ASD, autism spectrum disorders; DMSO, dimethylsulfoxyde; FDA, Food and Drug Administration; GAS, Global Assessment Scale; HTS, high throughput screening; hESC, human

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases

Keywords: HTS، غربالگری بالا; AMC, 3-amino-7-methyl-coumarin; DMSO, dimethyl sulfoxide; hK, human kallikrein; HTS, high throughput screening; LEKTI, lympho-epithelial Kazal-type inhibitorKallikreins; Matriptase; Inhibitors; Acyl-enzymes; Transient inactivators; Netherton syndrome

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway

Keywords: HTS، غربالگری بالا; METH, methamphetamine; ROS, reactive oxygen species; mTOR, mammalian target of rapamycin; FBS, fetal bovine serum; CAT, catalase; GPx, glutathione peroxidase; AVOs, acidic vesicular organelles; HTS, high throughput screening; Erk, extracellular signal reg

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors

Keywords: HTS، غربالگری بالا; Anc, anthranilic acid; DTT, dithiothreitol; GST, glutathione S-transferase; HRV, human rhinovirus; FI, fluorescence intensity; Fluoro, 5(6)-carboxyfluorescein; HPLC, high performance liquid chromatography; HTS, high throughput screening; IC50, half maxima

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases

Keywords: HTS، غربالگری بالا; Ub, ubiquitin; DUB, deubiquitylase; HTS, high throughput screening; AML, aminoluciferin; USP, ubiquitin specific protease; UCH, ubiquitin carboxyterminal hydrolase; SUMO, small ubiquitin-like modifier; NEDD8, nerounal precursor cell expressed developmentl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of Eph receptor–ephrin ligand interaction by tea polyphenols

Keywords: HTS، غربالگری بالا; AP, alkaline phosphatase; BSA, bovine serum albumin; EGCG, epigallocatechin-3-gallate; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; HGF, hepatocyte growth factor; HTS, high throughput screening; HUVECs, human umbilical vein endo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Online magnetic bead based dynamic protein affinity selection coupled to LC–MS for the screening of acetylcholine binding protein ligands

Keywords: HTS، غربالگری بالا; AChBP, acetylcholine binding protein; nAChRs, nicotinic acetylcholine receptors; IMAC, immobilized metal affinity chromatography; HTS, high throughput screening; PBS, phosphate buffered saline; BR, ELISA blocking reagent; ESI, electrospray ionisation; HOA

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Human hydroxysteroid dehydrogenases and pre-receptor regulation: Insights into inhibitor design and evaluation

Keywords: HTS، غربالگری بالا; AKR, aldo–keto reductases; AR, androgen receptor; ER, estrogen receptor; GA, glycyrrhetinic acid; GR, glucocorticoid receptor; HSD, hydroxysteroid dehydrogenase; HTS, high throughput screening; MR, mineralocorticoid receptor; NSAID, non-steroidal anti-inf

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR

Keywords: HTS، غربالگری بالا; HRS, high resolution screening; HTS, high throughput screening; RAD, receptor affinity detection; hER, human estrogen receptor ligand binding domain; NET, norethisterone; IT-TOF, ion trap-time of flight; CYPs, cytochrome P450s; HLM, human liver microsomes

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Identification and characterization of a novel estrogenic ligand actinopolymorphol A

Keywords: HTS، غربالگری بالا; BRET, bioluminescence resonance energy transfer; ERα, estrogen receptor α; ERβ, estrogen receptor β; LBD, ligand binding domain; FP, Fluorescence Polarization; HTS, high throughput screening; NPE, natural product extract; EDC, endocrine disrupting compoun

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Dengue virus replicons: Production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity

Keywords: HTS، غربالگری بالا; DV, dengue virus; DV2, DV serotype 2; DV3, DV serotype 3; EGFP, Enhanced Green Fluorescent Protein; HTS, high throughput screening; IRES, internal ribosome entry site; MTase, methyltransferase; NS5, non-structural protein 5; PAC, Puromycin N-Acetyltransfe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Identification and characterization of small compound inhibitors of human FATP2

Keywords: HTS، غربالگری بالا; Acsl, acyl-CoA synthetase long chain; FAF BSA, fatty acid-free bovine serum albumin; FATP, fatty acid transport protein; C1-BODIPY-C12, 4,4-difluoro-5-methyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoic acid; HTS, high throughput screening; MEM, minimal ess

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening

Keywords: HTS، غربالگری بالا; BSL4, biosafety level 4; CC50, concentration resulting in 50% cytotoxicity; DAPI, 4′,6-diamidino-2-phenylindole; HeV, Hendra virus; HRP, horse radish peroxidase; HTS, high throughput screening; IC50, concentration resulting in 50% inhibition; moi, multipl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Ready for a comeback of natural products in oncology

Keywords: HTS، غربالگری بالا; CRC, colorectal cancer; FDA, Food & Drug Administration; HTS, high throughput screening; NP, natural products; NSCLC, non-small cell lung cancer; SAR, structure–activity relationshipCancer; Natural products; Targets

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Identification and characterization of novel sirtuin inhibitor scaffolds

Keywords: HTS، غربالگری بالا; Sir2, silent information regulator number 2; Hst2, homologue of Sir two number 2; SIRT1, silent information regulator two number 1; HTS, high throughput screening; SAR, structure–activity relationship; ADME, absorption distribution metabolism and excretio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy

Keywords: HTS، غربالگری بالا; gene therapy; ribozyme; photoreceptor degeneration; rhodopsin; retinitis pigmentosaAS, antisense; ΔG, free energy (kcal/mol); hhRz, hammerhead ribozyme; HTS, high throughput screening; KD, knockdown; KD-RECON, knockdown-reconstitute approach to gene thera

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2009 سفارش ترجمه

Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus

Keywords: HTS، غربالگری بالا; NiV, Nipah virus; HeV, Hendra virus; BSL4, Biosafety Level 4; ELISA, enzyme linked immunosorbent assay; HTS, high throughput screening; EMEM, Eagle's modified essential medium; FCS, foetal calf serum; TCID, tissue culture infectious dose; TMB, 3,3’5,5’-te

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Structural determination of estrogen-related receptor γ in the presence of phenol derivative compounds

Keywords: HTS، غربالگری بالا; 4OHT, 4-hydroxy-tamoxifen; BPA, bisphenol A; ClCH3Ph, 4-chloro-3-methyl phenol; DES, di-ethylstilbestrol; ER, estrogen receptor; ERR, estrogen-related receptor; H12, helix 12; ΔHb, binding enthalpy; HTS, high throughput screening; LBD, ligand-binding doma

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

Keywords: HTS، غربالگری بالا; 4d/24w, 4 days/24-well plate format; 12d/6w, 12 days/6-well plate format; BBB, blood-brain barrier; HTS, high throughput screening; P-gp, P-glycoprotein; BBCEC, bovine brain capillary endothelial cells; DMEM, Dulbecco’s modified Eagle’s medium; CS, calf s

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

LBT/PTD dual tagged vector for purification, cellular protein delivery and visualization in living cells

Keywords: HTS، غربالگری بالا; GST, glutathione-S-transferase; HTS, high throughput screening; IPTG, isopropyl-β-d-thiogalactopyranoside; LB, Luria Broth media; DMEM, Dulbecco's modified Eagle's medium; OD, optical density; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays

Keywords: HTS، غربالگری بالا; ATP, adenosine 5′ triphosphate; BSA, bovine serum albumin; CV, coefficient of variation; FDA, Food and Drug Administration; HMG-CoA reductase, hydroxy methyl glutaryl Coenzyme A reductase; HTS, high throughput screening; IND, investigational new drug; NAD

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds

Keywords: HTS، غربالگری بالا; DMSO, dimethylsulfoxide; DPH, diphenylhydantoin; EB, embryoid body; ES cells, embryonic stem cells; EST, embryonic stem cell test; 5-FU, 5-fluorouracil; HTS, high throughput screening; ICH, International Conference on Harmonization; IC50D3, concentration

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF) with silver colloids in 96-well plates: Application to ultra fast and sensitive immunoassays, High Throughput Screening and drug discovery

Keywords: HTS، غربالگری بالا; AFM, Atomic Force Microscopy; BSA, Bovine Serum Albumin; HTS, High Throughput Screening; MAMEF, Microwave-Accelerated Metal-Enhanced Fluorescence; MEF, Metal-Enhanced Fluorescence; Mw, Low power microwave heating; RDE, Radiative Decay Engineering; TIRF, T

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Chemical tools for activity-based proteomics

Keywords: HTS، غربالگری بالا; ABP, activity-based probe; ABPP, activity-based protein profiling; α-CA, α-chloroacetamide; CID, collision induced dissociation; 2-DE, 2-dimensional electrophoresis; FAL, fluorescent affinity label; HTS, high throughput screening; IAC, inhibitor affinity

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2006 سفارش ترجمه