Keywords: پلی اتیل آمیلوئید جزیره انسان; AIns; iatrogenic insulin amyloid; ThT; thioflavin T; ANS; 8 anilinonaphthalene-1-sulfonic acid; APRs; aggregation prone regions; hIAPP; human islet amyloid polypeptide; CD; circular dichroism; TEM; transmission electron microscopy; PDB; protein data bank;
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Keywords: پلی اتیل آمیلوئید جزیره انسان; AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: پلی اتیل آمیلوئید جزیره انسان; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; ApoE-ε4; apolipoprotein E-ε4; BBB; blood-brain barrier; CTF; C-terminal fragment; DMN; default mode network; ER; endoplasmic reticulum; GLP-1; glucagon-like peptide-1; GLP-
Inhibition of amyloid peptide fibril formation by gold-sulfur complexes
Keywords: پلی اتیل آمیلوئید جزیره انسان; PrP; prion protein; hIAPP; human islet amyloid polypeptide; Aβ; amyloid-β protein; T2DM; type 2 diabetes mellitus; His; histidine; Met; methionine; DDTC; diethyl dithiocarbamate; PDT; pyrrolidine dithiocarbamate; DMSO; dimethyl sulphoxide; ThT; thioflav
Keywords: پلی اتیل آمیلوئید جزیره انسان; Peptide bond hydrolysis; Metal ions; Lewis acid; N â O acyl rearrangement; 1:1 Zr(IV)-Ld POM; Zr(IV)-substituted Lindqvist type polyoxometalate (Me4N)2[W5O18Zr(H2O)3]; 1:2 Ce(IV)-Kg POM; Ce(IV)-substituted Keggin-type polyoxometalate [Ce(α-PW11O39)2]
Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
Keywords: پلی اتیل آمیلوئید جزیره انسان; Human islet amyloid polypeptide; Type 2 diabetes; Amyloid aggregates; Conformational ensemble; Membrane disruption; Molecular dynamics simulations;
Nanoparticles modulate membrane interactions of human Islet amyloid polypeptide (hIAPP)
Keywords: پلی اتیل آمیلوئید جزیره انسان; Human Islet amyloid polypeptide; Nanoparticles; Amyloid fibrils; Nanoparticle-amyloid interactions;
Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells
Keywords: پلی اتیل آمیلوئید جزیره انسان; ASK1; apoptosis signal regulating kinase-1; BME; β-mercaptoethanol; GSH; glutathione; hA; human amylin; hIAPP; human islet amyloid polypeptide; HFIP; hexafluoride isopropanol; JNK; c-Jun N-terminal kinase; Lac; lactacystin; MAP; mitogen activated protein
IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies
Keywords: پلی اتیل آمیلوئید جزیره انسان; 2DIR; two-dimensional infra-red spectroscopy; AFM; atomic force microscopy; AGE; advanced glycation end; CD; circular dichroism; CGRP; calcitonin gene-related peptides; DMSO; Dimethyl Sulfoxide; EGCG; epigallocatechin gallate; EPR; electron paramagnetic r
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV
Keywords: پلی اتیل آمیلوئید جزیره انسان; DPP-IV; dipeptidyl peptidase IV; mg V·kgâ 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P
TRPV4 regulates insulin mRNA expression and INS-1E cell death via ERK1/2 and NO-dependent mechanisms
Keywords: پلی اتیل آمیلوئید جزیره انسان; 4α-PDD; 4α-phorbol 12,13-didecanoate; BrdU; 5-bromo-2â²-deoxyuridine; ERK1/2; extracellular signal-regulated kinase 1/2; GCK; glucokinase; GLP-1; glucagon-like peptide-1; hIAPP; human islet amyloid polypeptide; HPRT; hypoxanthine-guanine phosphoribos
ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules
Keywords: پلی اتیل آمیلوئید جزیره انسان; Aβ; amyloid-β peptide; Aβ40; amyloid-β peptide residues 1-40; AD; Alzheimer's disease; ADH; alcohol dehydrogenase; AFM; atomic force microscopy; CCS; collision-cross sectional area; Cl-NQTrp; chloronaphthoquinine-tryptophan; CsI; caesium iodide; D
Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment
Keywords: پلی اتیل آمیلوئید جزیره انسان; AFM; Atomic force microscopy; CD; circular dichroism; CC; Critical concentration of fibrillation; CuAAC; Cu(I)-catalyzed alkyne-azide cycloaddition; αCD; α-cyclodextrin; N3P3; cyclotriphosphazene; DIC; Diisopropylcarbodiimide; DIPEA; N,N-diisopropylet
In Vitro Evaluation of Hypoglycemic Agents to Target Human Islet Amyloid Polypeptide: A Key Protein Involved in Amyloid Deposition and Beta-Cell Loss
Keywords: پلی اتیل آمیلوئید جزیره انسان; antiamyloidogenic agents; hIAPP; human islet amyloid polypeptide; repaglinide; troglitazone; type 2 diabetesagents antiamyloïdogènes; hIAPP (human islet amyloid polypeptide); polypeptide amyloïde d’îlots pancréatiques humains; répaglinide; troglitazone; d
Effects of gold complexes on the assembly behavior of human islet amyloid polypeptide
Keywords: پلی اتیل آمیلوئید جزیره انسان; hIAPP, amylin; human islet amyloid polypeptide; rIAPP; rat IAPP; AuNPs; gold nanoparticles; PAH; poly (allylamine hydrochloride); ThT; thioflavin T; H2TPP; tetraphenylporphyrin; hIAPP; Assembly; Gold complex; Interaction; Dimerization;
Stabilities and structures of islet amyloid polypeptide (IAPP22-28) oligomers: From dimer to 16-mer
Keywords: پلی اتیل آمیلوئید جزیره انسان; hIAPP; human islet amyloid polypeptide; MD; molecular dynamics; Nucleation; Amyloid fibril; Molecular dynamics simulation; Islet amyloid polypeptide (residues 22-28); Type II diabetes;
Human IAPP amyloidogenic properties and pancreatic β-cell death
Keywords: پلی اتیل آمیلوئید جزیره انسان; hIAPP; Human islet amyloid polypeptide; Amylin; Amyloid; β-Cell death; Ion-channels; Type 2 diabetes mellitus; T2DM
Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides
Keywords: پلی اتیل آمیلوئید جزیره انسان; Spectroscopy; Type 2 diabetes; Confocal microscopy; Mitochondria; Amyloid; Model membranes; hIAPP; human islet amyloid polypeptide; IAPP; islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; rIAPP; rodent islet amy
Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms
Keywords: پلی اتیل آمیلوئید جزیره انسان; 4α-PDD; the phorbol ester 4α-phorbol 12,13-didecanoate; cAMP; cyclic adenosine monophosphate; hIAPP; human islet amyloid polypeptide; KRHB; Krebs-Ringer-HEPES buffer; PKC; protein kinase C; siRNA; small interfering RNA; nt siRNA; non-targeting siRNA;
Proanthocyanidins are the major anti-diabetic components of cinnamon water extract
Keywords: پلی اتیل آمیلوئید جزیره انسان; CD; circular dichroism; CWE; cinnamon water extract; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PA; proanthocyanidins; PBS
ReviewMolecular links between Alzheimer's disease and diabetes mellitus
Keywords: پلی اتیل آمیلوئید جزیره انسان; AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase
Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide
Keywords: پلی اتیل آمیلوئید جزیره انسان; CD; circular dichroism; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; T2DM; type 2 diabetes mellitus; TEM; transmission elect
Amphiphilic Adsorption of Human Islet Amyloid Polypeptide Aggregates to Lipid/Aqueous Interfaces
Keywords: پلی اتیل آمیلوئید جزیره انسان; sum frequency generation spectroscopy; vibrational hyperpolarizability; human islet amyloid polypeptide; divide-and-conquer normal mode analysis; ab initio simulation of SFG spectraSFG, sum frequency generation; hIAPP, human islet amyloid polypeptide; tpp
Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin
Keywords: پلی اتیل آمیلوئید جزیره انسان; Human islet amyloid polypeptide; Phycocyanin; Pancreatic beta cells; Apoptosis; Mitochondria
A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes
Keywords: پلی اتیل آمیلوئید جزیره انسان; Amylin; Amyloidogenesis; Diabetes mellitus type-2; Intrinsically disordered polypeptide; Ï-Ï stacking; AFM; atomic force microscopy; CFTR; cystic fibrosis transmembrane conductance regulator; CGRP; calcitonin gene related peptide; DM-2; type-2 diabete
Residue-specific structural kinetics of proteins through the union of isotope labeling, mid-IR pulse shaping, and coherent 2D IR spectroscopy
Keywords: پلی اتیل آمیلوئید جزیره انسان; 2D IR spectroscopy; Vibrational spectroscopy; Pulse shaping; Amyloid fibrils; Human islet amyloid polypeptide; Membrane protein;
Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways
Keywords: پلی اتیل آمیلوئید جزیره انسان; Human islet amyloid polypeptide; Phycocyanin; Apoptosis; Oxidative stress; Mitogen-activated protein kinases