Keywords: میکروسومهای کبدی انسانی; Electrocatalysis; Human liver microsomes; Magnetic nanoparticles; Drug metabolites; Drug biosensing;
مقالات ISI میکروسومهای کبدی انسانی (ترجمه نشده)
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Keywords: میکروسومهای کبدی انسانی; Acn; acetonitrile; GSH; glutathione; GST; glutathione S-transferase; HKM; human kidney microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatography; I.S.; internal standard; LC-MS; liquid chromatography mass spectrometry; NAPQI;
Keywords: میکروسومهای کبدی انسانی; AKR; aldo-keto reductase; AOX1; aldehyde oxidase 1; 11β-HSD; 11β-hydroxysteroid dehydrogenase; CBR; carbonyl reductase; CYP; cytochrome P450; EDTA; ethylenediamine-N,N,N',N'-tetraacetic acid; G-6-P; glucose-6-phosphate; G-6-PDH; glucose-6-phosphate
Keywords: میکروسومهای کبدی انسانی; AD; Alzheimer's disease; Aβ; amyloid β peptide; APP; amyloid precursor protein; BACE1; β-amyloid cleavage enzyme 1, β-secretase 1; GSM; gamma secretase modulator; LHS; left hand side; NSAID; non-steroidal anti-inflammatory drug; SAR; structure activ
Keywords: میکروسومهای کبدی انسانی; CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
Keywords: میکروسومهای کبدی انسانی; Metabolomics; LC-MS/MS; Human liver microsomes; Sildenafil; Cytochrome P450; Metabolite;
Keywords: میکروسومهای کبدی انسانی; Benzbromarone; Reactive metabolite; Glutathione adduct; Drug-induced liver injury; CYP; ABT; 1-aminobenzotriazole; BBR; benzbromarone; BSO; l-buthionine-sulfoximine; CYP; cytochrome P450; GSH; glutathione; HLM; human liver microsomes; HPLC; high-performan
Keywords: میکروسومهای کبدی انسانی; CV; coefficients of variation; eROS; enzymatic reactive oxygen species; FA; fenofibric acid; FF; fenofibrate; HLMs; human liver microsomes; mROS; micellar reactive oxygen species; NaPB; sodium phosphate buffer; NBT; nitroblue tetrazolium; ROS; reactive ox
Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry
Keywords: میکروسومهای کبدی انسانی; CYPs; cytochrome P450s; DB; Dragon's Blood; HLMs; human liver microsomes; HPLC-HR-MS; high performance liquid chromatography coupled with high resolution mass spectrometry; tR; retention time; Dragon's Blood; Human liver microsomes; HPLC-HR-MS; Metabolite
Keywords: میکروسومهای کبدی انسانی; BSA; bovine serum albumin; CYP; cytochrome P450; DDI; drug-drug interaction; DME; drug metabolizing enzyme; GST; glutathione-S-transferase; HLM; human liver microsomes; HSA; human serum albumin; NAT; N-acetyltransferase; NSAID; non-steroidal anti-inflamma
Keywords: میکروسومهای کبدی انسانی; physiologically based pharmacokinetic modeling; transporters; hepatobiliary disposition; hepatic metabolism; mathematical model; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; CYP; cytochrome P450 enzyme; CL; clearance;
Capillary electrophoresis in the context of drug discovery
Keywords: میکروسومهای کبدی انسانی; ACE; affinity capillary electrophoresis; AGP; α-acid glycoprotein; AH; adrenaline hydrochloride; AIμEA; automatic micro-enzyme assay; AL; amlodipine; AT; antithrombin III; Bag3; Bcl2-associated anthanogene 3; BGE; background electrolyte; CM; chylomicron
Keywords: میکروسومهای کبدی انسانی; PM; plasmepsin; SPP; signal peptide peptidase; HIV; human immunodeficiency virus; SAR; structure-activity relationships; BACE; beta-site APP cleaving enzyme 1 or beta-secretase; TCAMS; Tres Cantos Antimalarial Set; RBC; red blood cells; CatD; cathepsin
Keywords: میکروسومهای کبدی انسانی; CE; collision energy; CID; collision-induced dissociation; ESI; electrospray ionization; FAB; fast-atom bombardment; GSH; glutathione; HLM s; human liver microsomes; LC-MS/MS; liquid chromatography-tandem mass spectrometry; NAC; N-acetylcysteine; NADPH; Î
Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes
Keywords: میکروسومهای کبدی انسانی; Thymoquinone; Cytochrome P450; Metabolism; Human liver microsomes;
Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction
Keywords: میکروسومهای کبدی انسانی; drug interaction; drug metabolizing enzyme; cancer chemotherapy; human liver microsomes; in vitro-in vivo correlations (IVIVC); mass spectrometry; CYP; cytochrome P450; HRMS; high-resolution mass spectrometer; LC; liquid chromatography; MS; mass spect
The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo
Keywords: میکروسومهای کبدی انسانی; VRC; voriconazole; PPIs; proton pump inhibitors; LAN; lansoprazole; ESO; esomeprazol; OME; omeprazole; PAN; pantoprazole; ILA; ilaprazole; DDIs; drug-drug interactions; CYP; cytochrome P450; TDM; therapeutic drug monitoring; HLM; human liver microsomes; N
Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes
Keywords: میکروسومهای کبدی انسانی; Fisetin; Geraldol; Cytochrome P450; Inhibition; Human liver microsomes; Interaction;
Sulfotransferase-catalyzed biotransformation of liguzinediol and comparison of its metabolism in different species using UFLC-QTOF-MS
Keywords: میکروسومهای کبدی انسانی; LZDO; liguzinediol; Cys; cysteine; NAC; N-acetylcysteine; GSH; glutathione; 2-NAC-LZDO; 2-N-acetylcysteine-LZDO; 2-Cys-LZDO; 2-cysteine-LZDO; 2-GSH-LZDO; 2-glutathione-LZDO; HLC; human liver cytosol; HLM; human liver microsomes; RLC; rat liver cytosol; RL
Suspect and untargeted screening of bisphenol S metabolites produced by in vitro human liver metabolism
Keywords: میکروسومهای کبدی انسانی; Bisphenol S; In vitro metabolism; Human liver microsomes; High-resolution mass spectrometry; MZmine; Emerging contaminants;
In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury
Keywords: میکروسومهای کبدی انسانی; AADAC; arylacetamide deacetylase; AcetylCoA; acetyl coenzyme A; Ad; adenovirus; BNPP; bis-(p-nitrophenyl) phosphate; BSO; l-buthionine sulfoximine; CES; carboxylesterase; DFP; diisopropyl phosphorofluoride; DMSO; dimethyl sulfoxide; Eserine; sulfate physo
In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Keywords: میکروسومهای کبدی انسانی; Cloniprazepam; Designer benzodiazepines; In vitro biotransformation; Human liver microsomes; Cytosolic fractions; Liquid chromatography-mass spectrometry; High resolution-mass spectrometry;
Study of the in vitro and in vivo metabolism of 4-HO-MET
Keywords: میکروسومهای کبدی انسانی; 4-HO-MET; NPS; Synthetic tryptamine; Human liver microsomes; HPLC-IDA-HR-MS/MS; Metabolism;
Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism
Keywords: میکروسومهای کبدی انسانی; CYP; cytochrome P450; CYP-reductase; NADPH cytochrome P450 reductase; DCF-AG; diclofenac acyl glucuronide; DCF-SG; diclofenac glutathione conjugate; DILI; drug-induced liver injury; ESI; electrospray ionization; GST; glutathione S-transferase; GWAS; genom
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis
Keywords: میکروسومهای کبدی انسانی; CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte
Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects
Keywords: میکروسومهای کبدی انسانی; CYPs; cytochrome P450s; HDIs; herb-drug interactions; HLMs; human liver microsomes; NADPï¼; β-nicotinamide adenine dinucleotide phosphate; QSAR; quantitative structure activity relationship; CoMFA; comparative molecular field analysis; LC-MS; liquid c
Simultaneous monitoring of pazopanib and its metabolites by UPLC-MS/MS
Keywords: میکروسومهای کبدی انسانی; Metabolites; Human liver microsomes; Therapeutic drug monitoring; UPLC-MS/MS;
In-vitro metabolism, CYP profiling and metabolite identification of E- and Z- guggulsterone, a potent hypolipidmic agent
Keywords: میکروسومهای کبدی انسانی; 1-ABZT; 1-aminobenzotriazole; CYP450; cytochrome P450; HLM; human liver microsomes; IS; internal standard; LC-MS/MS; liquid chromatography-tandem mass spectrometry; NADPH; reduced form of nicotinamide adenine dinucleotide phosphate; HPLC; high-performan
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2
Keywords: میکروسومهای کبدی انسانی; Cytochrome P450; Inhibitory effects; Danshen; CYP2C8; CYP2J2; Herb-drug interactions; AA; arachidonic acid; CA; caffeic acid; Cry; cryptotanshinone; CYPs; Cytochrome P450 enzymes; DSS; danshensu; DI; dihydrotanshinone I; EETs; epoxyeicosatrienoic acids; F
Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes
Keywords: میکروسومهای کبدی انسانی; Estradiol (PubChem CID: 5757); Chenodeoxycholic acid (PubChem CID: 10133); Serotonin (PubChem CID: 5202); Propofol (PubChem CID: 4943); Zidovudine (PubChem CID: 35370); CYP; cytochrome P450; UGT; UDP-glucuronosyltransferases; DDI; drug-drug interactions;
Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites
Keywords: میکروسومهای کبدی انسانی; CYP4A11; Reaction phenotyping; HET0016; Plumbagin; Lauric acid metabolism; HLM; human liver microsomes; CYP; cytochrome P450; 20-HETE; 20-hydroxyeicosatetraenoic acids; LC-MS/MS; liquid chromatography-tandem mass spectrometry; IC50; the half maximal inh
A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine
Keywords: میکروسومهای کبدی انسانی; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m
Inhibition of Cytochrome P450 by Nomilin and Obacunone and Potential Mechanism in Human Liver Microsomes
Keywords: میکروسومهای کبدی انسانی; cytochrome P450; human liver microsomes; limonoids; nomilin; obacunone; time-dependent inhibition;
Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells
Keywords: میکروسومهای کبدی انسانی; Acetylshikonin; CYP2J2; Inhibition; Anti-cancer; HLMs; human liver microsomes; HCC; Hepatocellular carcinoma; DMSO; dimethyl sulfoxide; G6P; glucose-6-phosphate; G6PDH; G6P dehydrogenase; NADP+; β-nicotinamide dinucleotide phosphate; EETs; Epoxyeicosatri
Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro
Keywords: میکروسومهای کبدی انسانی; Diosmetin; Cytochrome P450; UDP-glucuronyltransferases; Hepatic uptake transporters; Drug-drug interactions; CYPs; Cytochrome P450 enzymes; DDI; drug-drug interactions; HDI; herb-drug interactions; HLMs; human liver microsomes; NTCP; Na+-taurocholate cotr
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: میکروسومهای کبدی انسانی; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Acyl glucuronide metabolites: Implications for drug safety assessment
Keywords: میکروسومهای کبدی انسانی; UGT; UDP glucuronyl transferase; UDP; uridine diphosphate; KPB; potassium phosphate buffer; HLM; human liver microsomes; IDT; idiosyncratic drug toxicity; HSA; human serum albumin; GSH; glutathione; NSAID; nonsteroidal anti-inflammatory drug; GSH; glutath
In vitro phase I metabolism of gamabufotalin and arenobufagin: Reveal the effect of substituent group on metabolic stability
Keywords: میکروسومهای کبدی انسانی; Gamabufotalin; Arenobufagin; CYP enzymes; Phase I metabolism; Human liver microsomes;
Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines
Keywords: میکروسومهای کبدی انسانی; Ferulic acid; Herb-drug interaction; Reaction phenotyping; Human liver microsomes;
Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay
Keywords: میکروسومهای کبدی انسانی; Ayurveda; Ridayarishta formulation; Standardization; Cytochrome P450 inhibition; Human liver microsomes; Herb-drug interaction;
CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol
Keywords: میکروسومهای کبدی انسانی; Hydroxytyrosol (PubChem CID: 82755); Tyrosol (PubChem CID: 10393); Nicotine (PubChem CID: 942); Coumarin (PubChem CID: 323); Dextromethorphan (PubChem CID: 6916184); Tryptamine (PubChem CID: 1150); Methoxsalen (PubChem CID: 4114); Tranylcypromine (PubChem
Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac
Keywords: میکروسومهای کبدی انسانی; APAP; acetaminophen; CLZ; clozapine; DCF; diclofenac; GSH; glutathione; GST; glutathione S-transferases; HLM; human liver microsomes; KPi; potassium phosphate; NMR; nuclear magnetic resonance; NAC; N-acetylcysteine; OPA; o-phthaldialdehyde; TMSP; trimethy
Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia
Keywords: میکروسومهای کبدی انسانی; DDI; drug-drug interaction; β-EST; β-estradiol; HLM; human liver microsomes; IV-IVE; in vitro-in vivo extrapolation; KI; kinase inhibitor; 4MU; 4-methylumbelliferone; LAP; lapatinib; NSB; non-specific binding; PAZ; pazopanib; PRO; propofol; REG; r
Retrospective identification of 25I-NBOMe metabolites in an intoxication case
Keywords: میکروسومهای کبدی انسانی; Intoxication; 25I-NBOMe; Metabolites; High-resolution mass spectrometry; Human liver microsomes;
Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction
Keywords: میکروسومهای کبدی انسانی; GC-MS; Human liver microsomes; Cytochrome P450; Cocktail approach; Socheongryong-tang; CAM; Complementary and alternative medicine; CV; Coefficient of variation; CYP; Cytochrome P450; GC-MS; DTE; dithioerythritol; Gas chromatography-mass spectrometry; HDI
Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast
Keywords: میکروسومهای کبدی انسانی; ADMET; absorption, distribution, metabolism, excretion, and toxicity; API; active pharmaceutical ingredient; CPR; NADPH-cytochrome P450 oxidoreductase; CYP; cytochrome P450; EMM; Edinburgh Minimal Medium; HLMs; human liver microsomes; RLU; relative lumine
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
Keywords: میکروسومهای کبدی انسانی; UDPGA; 5â²-diphosphoglucuronic acid; CRMs; chemically reactive metabolites; CYP; cytochrome P450; HLM; human liver microsomes; PHH; primary human hepatocytes; UGTs; UDP-glucuronosyltransferases; β-estradiol (PubChem CID:5757); Chenodeoxycholic acid (Pub
N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification
Keywords: میکروسومهای کبدی انسانی; HLM; human liver microsomes; MS; mass spectroscopy; NNAL; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; QTOF; quadrupole time-of-flight; UDPGA; uridine diphosphoglucuronic acid; UGT; UDP-glucuronosyltransferase; UPLC; ultra performance liquid chromatogra
Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases
Keywords: میکروسومهای کبدی انسانی; Adenosine; cAMP; Bioavailability; Propargyl; Heteroaryl; Human liver microsomes;
Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Keywords: میکروسومهای کبدی انسانی; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c