Keywords: پرفیوژن اندام تحتانی هیپرترمی; CPK; creatine phosphate; DMFS; distant metastatic-free survival; HILP; hyperthermic isolated limb perfusion; ILI; isolated limb infusion; LRFS; local recurrence-free survival; NED; no evidence of disease; ORR; overall response rate; OS; overall survival;