دانلود مقالات ISI درباره Ich S7B + ترجمه فارسی

The Diplomate in Safety Pharmacology (DSP) certification scheme

Keywords: DSP; Diplomate in Safety Pharmacology; SP; safety pharmacology; SPS; Safety Pharmacology Society; JSPS; Japanese Safety Pharmacology Society; ICH; International Conference on Harmonization; SOT; Society of Toxicology; ACT; American College of Toxicology;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition

Keywords: Exposure; Flow cell; hERG; ICH S7B; Methods; Patch-clamp; Screening; Solubility; Turbidometry; UV spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Utility of positive controls in assessing assay sensitivity in ICH S7B and ICH E14 guidance for evaluation of QT/QTc interval prolongation

Keywords: Assay sensitivity; ICH E14; ICH S7B; Positive control; QT interval

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

QTc shortening with a new investigational cancer drug: A brief case study

Keywords: Anesthetized dog; QT interval; hERG potassium current; ICH S7B; Electrophysiological methods; Rabbit Langendorff heart

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

If a drug deemed 'safe' in nonclinical tests subsequently prolongs QT in phase 1 studies, how can its sponsor convince regulators to allow development to proceed?

Keywords: CHMP; Committee for Medicinal Products for Human Use; COX; Cycloxygenase; ECG; Electrocardiogram; EU; European Union; FDA; Food and Drug Administration of the United States; hERG; Human ether-a-go-go related gene; ICH; International Conference on Harmoniz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential

Keywords: Action potential; Cardiac repolarization; Excipients; hERG potassium current; ICH S7B; In-vitro electrophysiological methods; Purkinje fiber; Whole-cell voltage-clamp

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve

Keywords: Action potential; Beagle dog; Cardiac repolarization; Droperidol; hERG channel; ICH S7B; Purkinje fiber; QT interval; Reprolarization reserve; Sotalol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Non-clinical evaluation of ventricular repolarization (ICH S7B): Results of an interim survey of international pharmaceutical companies

Keywords: QT interval; Ventricular repolarization; Survey; In vivo; In vitro; Risk assessment; ICH S7B; Safety pharmacology;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه