
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cell
Keywords: cAMP, cyclic AMP; EP receptor, E-type prostanoid receptor; PI3K, phosphatidylinositol 3-kinase; ERKs, extracellular signal-regulated kinases; PKA, protein kinase A; ICL, intracellular loop; PGE2, prostaglandin E2; COX-2, cyclooxygenase-2; EGF, epidermal g