
Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability
Keywords: DMF, N,N-dimethylformamide; GMP, Good Manufacturing Practice; HPLC, high-performance liquid chromatography; ICR, imprinting control region; ID, injected dose; K222, Kryptofix 2.2.2; log D, log P at physiological pH (7.4); MMP, matrix metalloproteinase; MM