4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site
Keywords: AMP-PNP-5â²; adenylyl-β,γ-imidodiphosphate; AUC; area under the receiver operating characteristic curve; DMSO; dimethyl sulfoxide; EF; enrichment factor; Fnorm; normalized fluorescence [â°] (per mill); GA; genetic algorithm; GHKL; Gyrase; Hsp90; histi