دانلود مقالات ISI درباره Ik1 + ترجمه فارسی

مدل سازی محاسباتی از اختلال تنظیم کلسیم ناشی از آمیلین در کاردیومیوسیت های بطنی موش صحرایی

Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes

Keywords: SL; sarcolemma; SR; saroplasmic reticulum; SERCA; sarcoplasmic/endoplasmic reticulum calcium ATPase; NCX; Na+/Ca2+ exchanger; EC; excitation-contraction; AP; action potential; LCC; L-type calcium channel; HIP; human amylin transgenic; NFAT; nuclear fact

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

فیبریلاسیون دهلیزی: نوروژنیک یا مگنی

Atrial fibrillation: Neurogenic or myogenic?

Keywords: Atrial fibrillation; Atrial neuropathy; Early diagnosis; Prediction; Therapy; Fibrillation atriale; Neuropathie atriale; Diagnostic précoce; Prédiction; Thérapie; AF; atrial fibrillation; ANS; autonomic nervous system; GP; ganglionated plexus; If; hype

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

بهبود فیبریلاسیون دهلیزی درمانی

Improving Atrial Fibrillation Therapy

Keywords: action potentials; antagomirs; gene therapy; genetic loci; genetic predisposition to disease; microRNAs; AF; atrial fibrillation; APD; action potential duration; CHF; congestive heart failure; DNA; deoxyribonucleic acid; GWAS; genome-wide association stud

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ساختن کاردیومیوسیت های انسانی تا به امروز: مشتق، حالت بلوغ و چشم انداز

Making human cardiomyocytes up to date: Derivation, maturation state and perspectives

Keywords: AM; Atrial cardiomyocyte; AP; Action potential; APA; Action potential amplitude; APD; Action potential duration; CICR; Ca2+-induced Ca2+ release; CK; Creatine kinase; CM; Cardiomyocyte; cTNI; Troponin I, cardiac type; cTnT; Cardiac troponin T; C × 40;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

اکتشاف فارماکولوژی ذخایر احتمالی غشای استراحت: تاثیر بر فیبریلاسیون دهلیزی

Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation

Keywords: IK1; IK,ACh; IK,Ca; INa; Resting membrane potential; Atrial fibrillation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

اثرات افتراق آنتی آنیوم های ترییدازین بر مدت فعالیت بالقوه ای در عضله پاپیلری خرگوش

Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle

Keywords: APD; action potential duration; ΔΔ-APD; drug effect on APD compared to control; APD90; 90% action potential duration; AAP; amplitude of the action potential; Vrest; resting membrane potential; IKr; rapid component of delayed rectifier potassium current;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

مکانیزم سلولی از کاردیومیوپاتی ناشی از انقباض بطنی زودرس

Cellular mechanism of premature ventricular contraction-induced cardiomyopathy

Keywords: AP; action potential; APD; action potential duration; [Ca2+]i; intracellular Ca2+ concentrations; CM; cardiomyopathy; CON; control; E-C; excitation-contraction; ICaL; L-type Ca current; IK1; inward rectifier current; IKr; rapid delayed rectifier current;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

عملکرد و تنظیم سرین / ترئونین فسفاتاز در قلب سالم و بیمار

Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

Keywords: AF; atrial fibrillation; AKAP; A-kinase-anchoring protein; AP; action potential; β-AR; β-adrenoceptor; CaMKII; Ca2 +/calmodulin-dependent protein kinase type-II; CKIP-1; casein kinase-2 interacting protein-1; cMyBP-C; cardiac myosin-binding protein-C;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1

Keywords: iPSC-CMs; IK1; Safety pharmacology; Arrhythmia; CiPA; Cardiac electrophysiology;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling

Keywords: aldosterone; atrial dilation; atrial fibrillation progression; fibrosis; upstream therapy; 7d-PeAF; first 7-day persistent atrial fibrillation episode; 11b-HSD2; 11β-hydroxysteroid dehydrogenase type 2; 12h-AF; first 12-h atrial fibrillation episode; AF;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative

Keywords: Action potential (AP); Action potential duration (APD); Cardiac voltage-gated ion channels; INa; Ito; IK1; hERG; IKs; In-vitro study; Cardiac action potential; Early afterdepolarization (EAD); Delayed afterdepolarization (DAD); Cardiac arrhythmias; QT pro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome

Keywords: channelopathy; genetics; short QT syndrome; sudden cardiac death; therapy; AF; atrial fibrillation; AP; action potential; ECG; electrocardiogram; ER; early repolarization; GWAS; genome-wide association studies; ICD; implantable cardioverter-defibrillator;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

Keywords: Comprehensive in vitro Proarrhythmia Assay (CiPA); Field potential data sampling and analysis; Induced pluripotent cell cardiomyocytes (hiPSC-CMs); Multi electrode array (MEA); Patch clamp technologies; Pending issues and solutions; Validation; Voltage se

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2 + leak in cardiomyocytes: Role of adenine nucleotide translocase

Keywords: AK2; adenylate kinase 2; ANT; adenine nucleotide translocase; Ap5A; P1P5-diadenosine-5′-pentaphosphate; BA; bongkrekic acid; C; carnitine; CsA; cyclosporine A; DPI; diphenyleneiodonium; FA; fatty acid; FKBP12.6; FK506 binding protein 12.6 kDa; IK1; inw

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Estrogen regulation of the transient outward K+ current involves estrogen receptor α in mouse heart

Keywords: CTL; control; E2; estrogen; ER; estrogen receptor; ERαKO; female mice lacking ERα; ERβKO; female mice lacking ERβ; GPER or GPR30; G-protein coupled estrogen receptor; IK1; inward K+ current; IKur; ultrarapid delayed rectifier K+ current; Ipeak; total

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

Keywords: AP; action potential; APD; action potential duration; ECG; electrocardiogram; IK1; inward rectifier potassium current; IKur; ultrarapid delayed rectifier potassium current; INa; sodium current; Iss; sustained potassium current; Ito; transient outward pota

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of the cardiac ATP-dependent potassium current by KB-R7943

Keywords: IKir; total inward rectifier K+ current; IKr; delayed rectifier K+ current; IK1; background inward rectifier K+ current; IKACh; acetylcholine-activated inward K+ rectifier current; IKATP; ATP-sensitive K+ current; NCX; sodium-calcium exchanger; INCX; Na

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

Keywords: APD; action potential duration; EAD; early afterdepolarization; ICa,L; L-type Ca2+ current; IK1; inward rectifier K+ current; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; KCNE1; β-subunit to KvLQT1 to form slow delayed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia

Keywords: ATS; Andersen-Tawil syndrome; CASQ2; calsequestrin-2; CPVT; catecholaminergic polymorphic ventricular tachycardia; ECG; electrocardiogram; IK1; inward rectifier current; LQT7; long QT syndrome type 7; OSH; outside hospital; PBS; phosphate buffer solution;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells

Keywords: CM; cardiomyocytes; MSC; mesenchymal stem cells; MSCNull; MSC transduced only with EGFP; MSCGATA-4; MSC transduced with GATA-4 and EGFP; IK1; inward rectifier K+ current; IKDR; delayed rectifier K+ current; Ito; transient outward K+ current; INa.TTX; TTX-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Electronic “expression” of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells

Keywords: AP; action potential; APD; action potential duration; DAD; delayed afterdepolarization; dV/dtmax; maximum rate of change of voltage with time; EAD; early afterdepolarization; h-iPSC; human-induced pluripotent stem cell; ICa; calcium current; If; pacemaker

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

N-ethylmaleimide activates a Cl−-independent component of K+ flux in mouse erythrocytes

Keywords: NEM; N-ethylmaleimide; KCC3; Slc12a6 K-Cl cotransporter; KCC1; Slc12a4 K-Cl cotransporter; IK1; KCNN4 intermediate conductance K+ channel, or Gardos channel.; DIDS; 4,4′-diisothiocyanato-2,2′-stilbenedisulfonic acid; EGTA; ethylene glycol tetra-ac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation

Keywords: AF; atrial fibrillation; AP; action potential; APD; AP duration; cAF; chronic AF; CCh; carbachol; ICa,L; L-type Ca2 + current; IK1; basal inward-rectifier K+ current; IK,ACh; muscarinic-receptor-activated K+ current; INaK; Na+-K+ ATPase current; [Na+]i;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore

Keywords: Propafenone; Human atrial myocytes; IK1; PIP2; Rectification; Inward rectifier channels

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome

Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation

Keywords: Kv channels; Kir channels; Kv4.3; macromolecular Kv channel complexes; posttranslational regulation/modulation; CaM; calcium calmodulin; CaMKII; calcium calmodulin-dependent protein kinase II; Ito,f; fast, transient voltage-dependent K+ current; IKr; rapi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Extracellular K+ elevates outward currents through Kir2.1 channels by increasing single-channel conductance

Keywords: Kir; inward rectifier K+ channels; IK1; Kir2.1 currents; [K+]o; extracellular K+ concentration; Vm; membrane potential; k1; rate constant for the transition from the closed to the open state; k−1; rate constant for the transition from the open to the cl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome

Keywords: Arrhythmia mechanism; Cellular calcium; Mapping; Repolarization; Ventricular arrhythmia; APD; action potential duration; APD50; 50% of action potential duration; ATS1; Anderson-Tawil syndrome; BCL; basic cycle length; Ca2+; calcium; [Ca2+]i; cytosolic Ca2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Cardiac strong inward rectifier potassium channels

Keywords: Kir channels; IK1; IKACh; Cardiac excitability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation

Keywords: Inward rectifier potassium currents; IKACh; IK1; connexin; atrial fibrillation; microRNAAF, atrial fibrillation; BSA, bovine serum albumin; CAD, coronary artery disease; Cx, connexin; DTT, dithiothreitol; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; L

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (IKs) potassium channels

Keywords: Tanshinone IIA; hKCNQ1/hKCNE1; IKs; Kv1.5; hERG; IK1; HEK 293 cell; Potassium channel; Ion channel; Patch clamp; Human

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation - A simulation study

Keywords: Arrhythmia; Sudden death; Ion channels; Fibrillation atrial; Gene mutation; Channelopathy; Inward rectifier; IK1; Potassium channel; Δt; time delay; 1D, 2D, 3D; one-, two- and three-dimensional model; AF; atrial fibrillation; AP; action potential; APD; a

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective

Keywords: Action potential; Anoxia; Carassius carassius; Crucian carp; Electrophysiology; Heart; ICa; IK1; IKr; INa; K+ channel; L-type Ca2+ channel; Na+ channel; Red-eared slider turtle; Temperature; Thermal acclimation; Trachemys scripta;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Bending of z-lines by mechanical stimuli: An input signal for integrin dependent modulation of ion channels?

Keywords: Mechanical stimulus; Cell z-line deviation; Cell stiffness; ISAC; IK1; Cytoskeleton; Cardiac ageing

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2008 سفارش ترجمه

Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation

Keywords: Cardiac hypertrophy; Heart failure; Renin-angiotensin system; Angiotensin II; Action potential; Arrhythmia; Electrocardiography; Long QT syndrome; IK1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells

Keywords: pH sensitivity; Kir2.1; Kir2.3; IK1; Heteromerization

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Cardiac IK1 underlies early action potential shortening during hypoxia in the mouse heart

Keywords: IK1; Hypoxia; Action potential; Repolarization; Myocytes

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis

Keywords: IK1; Kir2.x channels; Reentry; Rotors; Ventricular fibrillation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه