دانلود مقالات ISI درباره Ikr + ترجمه فارسی

Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome

Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation

Keywords: Kv channels; Kir channels; Kv4.3; macromolecular Kv channel complexes; posttranslational regulation/modulation; CaM; calcium calmodulin; CaMKII; calcium calmodulin-dependent protein kinase II; Ito,f; fast, transient voltage-dependent K+ current; IKr; rapi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Lysophosphatidylcholine enhances IKs currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways

Keywords: LPC; lysophosphatidylcholine; LPC-16; 1-palmitoyl-lysophosphatidylcholine; LPC-6; 1-caproyl-lysophosphatidylcholine; LPC-18:1; 1-oleoyl-lysophosphatidylcholine; PC; phosphatidylcholine; SPC; sphingosylphosphorylcholine; IKs; slow activating component of d

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

A novel mutation in the KCNH2 gene associated with short QT syndrome

Keywords: Short QT syndrome; Sudden death; QT; Tp-e/QT; Genetics; Channelopathy; HERG; IKr;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The hERG K+ channel S4 domain L532P mutation: Characterization at 37 °C

Keywords: Arrhythmia; Dronedarone; hERG; IKr; Short QT syndrome; Potassium channel;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

Keywords: Bupivacaine; Cardiotoxicity; Electrophysiology; hERG channel; Molecular docking; Stereoselectivity; AP; action potential; cLQTS; congenital long QT syndrome; diLQTS; drug-induced long QT syndrome; ECG; electrocardiogram; ES; extracellular solution; GB/SA;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs

Keywords: Astemizole; hERG channel; IKr; Teratogenicity; Hypoxia; Embryonic cardiac adverse effects

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of recombinant hERG K+ channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Keywords: Amiodarone; Antiarrhythmic; Class III; Desethyl-amiodarone; hERG; human ether-à-go-go-related gene; IKr; QT interval; Potassium channel;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1

Keywords: DPO-1; diphenylphosphine oxide-1; APD; action potential duration; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; IKur; ultra-rapid delayed rectifier current; IC50; the concentration of drug required for 50% block of curre

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation of cardiac ERG1 K+ channels by cGMP signaling

Keywords: hERG; cGMP; APD; IKr; ANP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Antiarrhythmic effect of IKr activation in a cellular model of LQT3

Keywords: hERG1; Kv11.1; LQT3; IKr; Long QT syndrome 3; NS3623; Mallotoxin; Heart; Ventricular arrhythmia; Guinea pig

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of methylphenidate hydrochloride on the cardiovascular system in vivo and in vitro: A safety pharmacology study

Keywords: Attention deficit hyperactivity disorder (ADHD); Methylphenidate hydrochloride; Cardiovascular system; QTcF interval; Action potential duration; IKr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients

Keywords: Long QT syndrome; IKr; KCNH2 mutation; α1A-adrenoceptor; β1- and β2-adrenoceptor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative

Keywords: APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method

Keywords: Electrocardiogram; Restitution; Torsades de pointes; Arrhythmia; Autonomic tone; Translation to humans; BPM; beats per minute; ECG; electrocardiogram; IKr; rapid potassium delayed rectifier current; IKs; slow potassium delayed rectifier current; PK; pharm

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Model systems for the discovery and development of antiarrhythmic drugs

Keywords: Arrhythmias; Ion channel blockers; Ion currents; Reentry; AF; atrial fibrillation; APD; action potential duration; CAVB; chronic atrio-ventricular block; CHF; congestive heart failure; DAD; delayed afterdepolarization; EAD; early afterdepolarization; hERG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective

Keywords: Action potential; Anoxia; Carassius carassius; Crucian carp; Electrophysiology; Heart; ICa; IK1; IKr; INa; K+ channel; L-type Ca2+ channel; Na+ channel; Red-eared slider turtle; Temperature; Thermal acclimation; Trachemys scripta;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

Keywords: Antidepressant; Arrhythmia; Doxepin; HERG; IKr; Long QT syndrome; Potassium channel; QT interval; QT-prolongation; Rapid delayed rectifier; Short QT syndrome; Torsade de pointes;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Erythromycin block of the HERG K+ channel: Accessibility to F656 and Y652

Keywords: Erythromycin; Long QT syndrome; HERG; IKr; Rapid delayed rectifier

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine

Keywords: Prochlorperazine; Antiemetic drug; HERG channel; IKr; Long QT syndrome; Arrhythmias

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias

Keywords: AP; action potential; IC50; concentration at 50% inhibition; TdP; torsades de pointes; Ventricular arrhythmias; Guidelines; IKr; Drug effects; QT prolongation; Repolarisation;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه

Is erythromycin therapy teratogenic in humans?

Keywords: Erythromycin; Teratogenicity; Cardiovascular defects; Pyloric stenosis; Epidemiology; IKr; hERG;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents

Keywords: Lamotrigine; Topiramate and gabapentin; hERG; IKr; Sudden death;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

The N588K-HERG K+ channel mutation in the 'short QT syndrome': Mechanism of gain-in-function determined at 37 °C

Keywords: Arrhythmia; HERG; IKr; Rapid delayed rectifier; Turret; CHO cells; Long QT syndrome; Potassium channel; Short QT syndrome; Sudden death;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Both β-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of IKs channel blockers in vitro

Keywords: IKs; IKr; Action potential duration (APD); IKs channel blockers; Triangulation; Tissue-specific difference; β-adrenoceptor receptor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Nonclinical proarrhythmia models: Predicting Torsades de Pointes

Keywords: AP; Action potential; APD; Action potential duration; APD90; Action potential duration at 90% repolarization; A-V; Atrioventricular; CAVB; Chronically A-V block; CV; Conduction velocity; EADs; Early after-depolarizations; ECG; Electrocardiogram; hERG; Hum

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit

Keywords: Ikr; APD (action potential duration); Drug-induced long QT; EADs (early afterdepolarizations); Tissue-specific difference; Long QT syndrome (LQT);

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه