
Structure–activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201
Keywords: IL-12، اینترلوکین-12; ArPIKfyve, associated regulator of PIKfyve; DNLC, direct nanoflow liquid chromatography; GSK3, glycogen synthase kinase 3; IBD, inflammatory bowel disease; IFN-γ, interferon-gamma; IL-12, interleukin-12; LPS, lipopolysaccharide; mTOR, mammalian target of