
Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells
Keywords: cataracts; valproic acid; ER stress; DNA methylation; unfolded protein response; Nrf2; Keap1 promoter demethylation; ARCs; age-related cataracts; ATF4; activating transcription factor 4; BiP; immunoglobulin heavy-chain binding protein; CHOP; C/EBP-homolog