Keywords: IMS، فضای میانمبار; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; LRRK2, leucine-rich repeat kinase 2; HTRA2, high temperature requirement protein A2; PD, Parkinson disease; PINK1, PTEN-induced putative kinase 1; IMS, intermembrane space; OMM, outer mitochondrial membr
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Keywords: IMS، فضای میانمبار; Bcl-2, B cell CLL/lymphoma-2; Cer, ceramide; CerS, ceramide synthase; DES, dihydroceramide desaturase; DHCer, dihydroceramide; ER, endoplasmic reticulum; IMS, intermembrane space; KSR, 3-ketosphinganine reductase; MOMP, mitochondrial outer membrane permea
Keywords: IMS، فضای میانمبار; CCCP, carbonyl cyanide 3-chlorophenylhydrazone; CDP-DAG, CDP-diacylglycerol; CL, cardiolipin; ERMES, ER–mitochondriaencounter structure; IM, inner membrane; IMS, intermembrane space; OM, outer membrane; PA, phosphatidic acid; PG, phosphatidylglycerol; PGP
P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells
Keywords: IMS، فضای میانمبار; CHX, cycloheximide; ER, endoplasmic reticulum; hESC, human embryonic stem cell; hiPSC, human induced pluripotent stem cell; hPSC, human pluripotent stem cell; IMS, intermembrane space; MOMP, mitochondrial outer membrane permeabilization; PARP, poly(ADP-ri
Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion
Keywords: IMS، فضای میانمبار; AIF, apoptosis-inducing factor; AK2, adenylate kinase 2; BSA, bovine serum albumin; CsA, cyclosporine A; DMF, N,N-dimethylformamide; IM, inner membrane; IMS, intermembrane space; IR, ischemia–reperfusion; LAD, left anterior descending coronary artery; MI,
Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria
Keywords: IMS، فضای میانمبار; IMS, intermembrane space; IM, inner membrane; DSP, dithiobis(succinimidylpropionate); PK, proteinase Kmitochondria; protein translocation; protein sorting; TIM23
Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis
Keywords: IMS، فضای میانمبار; BH, BCL-2 homology; CL, cardiolipin; DISC, death-inducing signalling complex; IMS, intermembrane space; MIM, mitochondrial inner membrane; MOM, mitochondrial outer membrane; MOMP, mitochondrial outer membrane permeabilizationApoptosis; Mitochondria; Cardi
The mitochondrial rhomboid protease: Its rise from obscurity to the pinnacle of disease-relevant genes
Keywords: IMS، فضای میانمبار; TMD, transmembrane domain; IMS, intermembrane space; PD, Parkinson's disease; T2D, type 2 diabetesIntramembrane proteolysis; Substrate; Mitochondrial fusion; Apoptosis; Mitophagy
Mitochondrial proteases and cancer
Keywords: IMS، فضای میانمبار; COX, cytochrome c oxidase; HIF, hypoxia inducible factor; IM, inner mitochondrial membrane; IMS, intermembrane space; mtDNA, mitochondrial DNA; OM, outer mitochondrial membrane; PHB, prohibitn complex; PDZ, PDZ domain; PHD, prolyl hydroxylase domain enzym
Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL
Keywords: IMS، فضای میانمبار; PSAP/Mtch1, presenilin 1-associated protein/mitochondrial carrier homolog 1; MOM, mitochondrial outer membrane; IMS, intermembrane space; MOMP, mitochondrial outer membrane permeabilization; TMD, transmembrane domain; mRFP, monomeric red fluorescent prote
A suggested role for mitochondria in Noonan syndrome
Keywords: IMS، فضای میانمبار; CcO, cytochrome c oxidase; Cytc, cytochrome c; CS, citrate synthase; ETC, electron transport chain; IMS, intermembrane space; KD, knockdown; NS, Noonan syndrome; OxPhos, oxidative phosphorylation; WT, wild-typeCardio-facio-cutaneous syndrome; Cytochrome c
A Tag at the Carboxy Terminus Prevents Membrane Integration of VDAC1 in Mammalian Mitochondria
Keywords: IMS، فضای میانمبار; BN-PAGE, blue native polyacrylamide gel electrophoresis; IMM, inner mitochondrial membrane; IMS, intermembrane space; OMM, outer mitochondrial membrane; SAM, sorting and assembly machinery; TOM, translocase of the outer membrane; VDAC, voltage-dependent a
Probing the orientation of yeast VDAC1 in vivo
Keywords: IMS، فضای میانمبار; OMM, outer mitochondrial membrane; IMS, intermembrane space; scVDAC, Saccharomyces cerevisiae VDAC; hsVDAC, human VDAC; IP, immunoprecipitationVoltage dependent anion channel; Mitochondrial porin; Structure; Immunoprecipitation; Yeast
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis
Keywords: IMS، فضای میانمبار; CGN, cerebellar granule neuron; CHX, cycloheximide; Drp1, dynamin-related protein-1; ExPASy, Expert Protein Analysis System; IMS, intermembrane space; IMSTD, intermembrane space targeting domain; MIB, mitochondrial isolation buffer; MTS, mitochondrial tar
Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
Keywords: IMS، فضای میانمبار; ER, endoplasmic reticulum; GSLs, glicerolosphingolipids; IMS, intermembrane space; IP3R, inositol 1,4,5-triphosphate receptor; MAM, mitochondria-associated membranes; Mfn, mitofusin; OSBP, oxysterol binding protein; PAM, plasma membrane-associated membran
Systematic Analysis of the Twin Cx9C Protein Family
Keywords: IMS، فضای میانمبار; Cmc, Cx9C motif-containing protein; IMS, intermembrane space; ORF, open reading frame; MISS, mitochondrial intermembrane space sortingErv1; Mia40; mitochondria; respiration; twin Cx9C proteins
Cryo-Electron Microscopy Structure of a Yeast Mitochondrial Preprotein Translocase
Keywords: IMS، فضای میانمبار; TOM, translocase of the outer mitochondrial membrane; SAM, sorting and assembly machinery; TIM, translocase of the inner membrane; IMS, intermembrane space; GIP, general import pore; EM, electron microscopy; TM, transmembrane; 3D, three-dimensional; NTA,
Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins
Keywords: IMS، فضای میانمبار; CIA, cytoplasmic Fe–S cluster protein assembly; COX, cytochrome c oxidase; IMS, intermembrane space; MIA, mitochondrial intermembrane space assembly; ROS, reactive oxygen species; TIM, translocase of the inner membraneMitochondria; Disulphide exchange; Mi
Mim1 Functions in an Oligomeric Form to Facilitate the Integration of Tom20 into the Mitochondrial Outer Membrane
Keywords: IMS، فضای میانمبار; TOM, translocase of the outer mitochondrial membrane; Mim1, mitochondrial import protein 1; TMS, transmembrane segment; TOB, topogenesis of mitochondrial outer membrane β-barrel proteins; IMS, intermembrane space; BN, blue native; WT, wild type; DSG, disu
Assembly of the Mitochondrial Tim9–Tim10 Complex: A Multi-step Reaction with Novel Intermediates
Keywords: IMS، فضای میانمبار; IMS, intermembrane space; Tim, translocase of inner membrane; AAC, ADP/ATP carrier; RCF, relative centrifugal fieldcomplex formation; stopped-flow fluorescence; mutagenesis; stopped-flow light scattering; kinetics
The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway
Keywords: IMS، فضای میانمبار; IMS, intermembrane space; ΔΨ, membrane potential; FAD, flavine adenine dinucleotide; NEM, N-ethylmaleimide; DTT, dithiothreitol; PK, proteinase KProtein import; Mia40-import pathway; Sulfhydryl oxidase Erv1; Mitochondria; Disulfide bond
Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch
Keywords: IMS، فضای میانمبار; Bcl-2, B-cell lymphoma 2; MOMP, mitochondrial outer membrane permeabilization; IMS, intermembrane space; BH domain, Bcl-2 homology domain; MAC, mitochondrial apoptosis channel; ODEs, ordinary differential equationsApoptosis; Bcl-2 apoptotic switch; Model;
Preprotein Transport Machineries of Yeast Mitochondrial Outer Membrane Are not Required for Bax-induced Release of Intermembrane Space Proteins
Keywords: IMS، فضای میانمبار; CCHL, cytochrome c heme lyase; Δψ, membrane potential; IMS, intermembrane space; Mcr1, mitochondrial NADH-cytochrome b5 reductase; MIA, mitochondrial intermembrane space import and assembly; PVDF, polyvinylidene difluoride; SAM, sorting and assembly machi
Toc64 - A Preprotein-receptor at the Outer Membrane with Bipartide Function
Keywords: IMS، فضای میانمبار; IAM, indol-3-acetamide; IMS, intermembrane space; OEVs, outer envelope vesicles; pOE33, precursor of the oxygen evolving complex component of 33 kDa; p/mSSU, precursor/mature protein form of the small subunit of RubisCO; TocX, translocon on the outer memb
Mitochondrial morphology and protein import—A tight connection?
Keywords: IMS، فضای میانمبار; Δψ, membrane potential; IMS, intermembrane space; PAM, presequence translocase-associated motor; SAM, sorting and assembly machinery; TIM, translocase of the inner membrane; TOM, translocase of the outer membraneMitochondria; Protein import; Protein assem
The Presequence of Fumarase is Exposed to the Cytosol during Import into Mitochondria
Keywords: IMS، فضای میانمبار; fumarase; co-translational translocation; mitochondrial import; dual distribution; presequenceMPP, mitochondrial processing peptidase; ER, endoplasmic reticulum; IMS, intermembrane space; CCCP, carbonyl cyanide m-chlorophenylhydrazone