دانلود مقالات ISI درباره In Vitro-In Vivo Extrapolation + ترجمه فارسی

بحث بر روی مدل کبد به خوبی همزاد: مجدد مجدد از مدل پراکندگی و دوباره تجزیه و تحلیل داده های لیدوکائین

Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data

Keywords: AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

مطالعات متابولیسم آفت کش های شیمیایی: بررسی انتقادی

Metabolism studies of chiral pesticides: A critical review

Keywords: AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Lost in translation: What's in an EC50? Innovative PK/PD reasoning in the drug development context

Keywords: Potency; Target turnover; Variability; In vitro-in vivo extrapolation; Inter-species scaling; Translation;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat

Keywords: Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation

Keywords: Protein binding; Albumin-facilitated uptake; In vitro-in vivo extrapolation;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: A case study using the BCS/BDDCS Class II drug nifedipine

Keywords: Food effects; Simcyp ADAM model; Mechanistic modelling; In vitro-in vivo extrapolation; Oral formulation; PBPK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

Keywords: distribution; hepatocytes; liver; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه