Keywords: ساختار متوسط; FBPase; fructose-1,6-bisphosphatase; FBP; d-fructose-1,6-bisphosphate; F6P; d-fructose-6-phosphate; Pi; orthophosphate; QM/MM; quantum mechanical/molecular mechanical; HB; hydrogen bond; MD; molecular dynamic; RS; reactant structure; TS; transition state;