Keywords: پاکسازی ذاتی; AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa
مقالات ISI پاکسازی ذاتی (ترجمه نشده)
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Keywords: پاکسازی ذاتی; AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;
Keywords: پاکسازی ذاتی; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: پاکسازی ذاتی; Clint; intrinsic clearance; Clint app.; apparent intrinsic clearance; DAD; diod array detector; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; fu; unbound fraction of a drug in the microsomal incubation mixture; HPLC; high performance liquid chromat
Keywords: پاکسازی ذاتی; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: پاکسازی ذاتی; AUC; area under the plasma concentration-time curve; B/P; blood-to-plasma ratio; CYP; cytochrome P450; CLint; intrinsic clearance; Cmax; maximum plasma concentration; CLPD; passive permeability-surface area product; DDI; drug-drug interaction; fa; fract
Keywords: پاکسازی ذاتی; ADH; alcohol dehydrogenase; BSA; body surface area; BH; body height; BW; body weight; Clint; intrinsic clearance; Clintad; intrinsic clearance in average adult; Clintind; intrinsic clearance in any individual; CAss; arterial blood concentration at steady-
Kinetic characterization of bile salt transport by human NTCP (SLC10A1)
Keywords: پاکسازی ذاتی; NTCP; SLC10A1; Glycochenodeoxycholate; 3-Sulfo-glycolithocholate; Kinetics; Intrinsic clearance;
Development of human biotransformation QSARs and application for PBT assessment refinement
Keywords: پاکسازی ذاتی; In vivo biotransformation; Biotransformation half-life; QSAR; Hazard assessment; Refined PBT assessment; 1-CoPK; one-compartment pharmacokinetic model; AD; Applicability Domain; ADME; Absorption, Distribution, Metabolism and Elimination; B; Bioaccumulati
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
Keywords: پاکسازی ذاتی; AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin
Keywords: پاکسازی ذاتی; CLint; intrinsic clearance; CYP; cytochrome P450; HPLC; high performance liquid chromatography; Km; Michaelis-Menten constant; MS; mass spectroscopy; PAPS; 3â²-Phosphoadenosine-5â²-phosphosulfate; QTOF; Quadrupole time-of-flight; shRNA; short hairpin RN
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis
Keywords: پاکسازی ذاتی; CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte
Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes
Keywords: پاکسازی ذاتی; Bile canaliculi; Collagen; Hepatic drug disposition; Methods; Sandwich-cultured rat hepatocytes; AUC; Area Under the Curve; BEI; biliary excretion index; CDF; 5-(6)-carboxy-2-dichlorofluorescein; CDFDA; 5-(6)-carboxy-2-dichlorofluorescein diacetate; Clint
Effect of genetic polymorphism on the inhibition of dopamine formation from p-tyramine catalyzed by brain cytochrome P450 2D6
Keywords: پاکسازی ذاتی; CYP2D6; Dopamine formation; Genetic polymorphism; Drug interaction; CLint; intrinsic clearance; CYP or P450; cytochrome P450; DHEA; dehydroepiandrosterone; IC50; 50% inhibitory concentration; Iu; unbound concentration of the inhibitor; Ki; inhibitory cons
Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro
Keywords: پاکسازی ذاتی; Ketamine; CYP2C9; Gene polymorphism; Metabolism; Intrinsic clearance;
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: پاکسازی ذاتی; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
Keywords: پاکسازی ذاتی; CYP3A4; NADPH-cytochrome P450 reductase; Caco-2Â cells; Human artificial chromosome vector; Intestinal metabolism; ABT; 1-aminobenzotriazole; CLint; intrinsic clearance; CPR; NADPH-cytochrome P450 reductase; Ct; threshold cycle; CYP; cytochrome P450; Eg;
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clea
Keywords: پاکسازی ذاتی; Fatty acids; CYP450 enzymes; Enzyme inhibition; Michaelis-Menten kinetics; Bovine serum albumin (BSA); Intrinsic clearance; Well-stirred model; Hepatic clearance; In vitro - In vivo extrapolation (IVIVE);
Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids
Keywords: پاکسازی ذاتی; AUDA; 212-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid; 4-HBP; 4-hydroxybenzophenone; ACN; acetonitrile; CLother(AA); aggregate clearance of other pathways of AA; CLother(EET); aggregate clearance of other pathways of EET; AA; arac
Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Keywords: پاکسازی ذاتی; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c
Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of ursolic acid
Keywords: پاکسازی ذاتی; Ursolic acid; UDP-glucuronosyltransferases; Metabolism pathway; Metabolism characterization; UA; ursolic acid; HLMs; human liver microsomes; HIMs; human intestinal microsomes; UGTs; UDP-glucuronosyltransferases; DDI; drug-drug interactions; RILD; Resear
Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases
Keywords: پاکسازی ذاتی; GA; glabridin; UGT; UDP-glucuronosyltransferases; HLM and HIM; liver and intestinal microsomes from humans, respectively; RLM and RIM; liver and intestinal microsomes from rats, respectively; CyLM and DLM; liver microsomes from cynomolgus monkeys and beag
In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes
Keywords: پاکسازی ذاتی; Benzo[a]pyrene; Dibenzo[def,p]chrysene; Michaelis–Menten; VMAX; KM; Intrinsic clearance
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling
Keywords: پاکسازی ذاتی; AUC; area under the plasma concentration-time curve; DDI; drug-drug interaction; CLint; intrinsic clearance; BCRP; Breast Cancer Resistance Protein; HEK293; Human Embryonic Kidney 293 (cell-line); MRP; Multidrug resistance-associated protein; NTCP; Sodi
In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat
Keywords: پاکسازی ذاتی; DEHP; In vitro hepatic metabolism; In vitro intestinal metabolism; Human; Rat; Intrinsic clearance;
Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs
Keywords: پاکسازی ذاتی; hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;
Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data
Keywords: پاکسازی ذاتی; hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling
Stereoselectivity in Pharmacokinetics of Rivoglitazone, A Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys: Model-Based Pharmacokinetic Analysis and In Vitro-In Vivo Extrapolation Approach
Keywords: پاکسازی ذاتی; pharmacokinetics; protein binding; metabolic clearance; metabolism; distribution; chiral inversion; stereoselectivity; in vitro–in vivo extrapolation (IVIVE); unbound fraction; intrinsic clearance
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
Keywords: پاکسازی ذاتی; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch
Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs
Keywords: پاکسازی ذاتی; in vitro-in vivo correlations (IVIVC); hepatocytes; microsomes; clearance; intrinsic clearance; protein binding; prediction; precision; bias;
Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin
Keywords: پاکسازی ذاتی; AIC; Akaike's information criterion; UGT; UDP-glucuronosyltransferase; UDPGA; uridine diphosphoglucuronic acid; LTC4; leukotriene C4; NTP; National Toxicology Program; SD; Sprague-Dawley; DMEM; Dulbecco's modified Eagle's medium; AP; apical; BL; basolat
Analogue tracers and lumped constant in capillary beds
Keywords: پاکسازی ذاتی; Microvascular tracer kinetics in vivo; Intrinsic clearance; 2-[18F]Fluoro-2-deoxy-d-glucose PET; Positron emission tomography; Bi-substrate enzyme kinetics
Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
Keywords: پاکسازی ذاتی; SDR; short-chain dehydrogenyse/reductase; AKR; aldo-keto reductase; 11β-HSD1; 11β-hydroxysteroid dehydrogenase 1; ANT; anthracycline; DAUN; daunorubicin; DAUNOL; daunorubicinol; ADAUN; aglycone of daunorubicin; ADAUNOL; aglycone of daunorubicinol; DOX;
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
Keywords: پاکسازی ذاتی; Hepatocyte characterization methods; Cytochrome P450; HepaRG; Intrinsic clearance; P450 enzyme induction; Primary human hepatocytes
On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay
Keywords: پاکسازی ذاتی; hepatic clearance; intrinsic clearance; metabolic stability; protein binding; microsomal binding; well-stirred model; pharmacokinetics;
Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance
Keywords: پاکسازی ذاتی; Hepatocytes; In vivo; In vitro; Intrinsic clearance; Microsomes
Pharmacokinetics of Chlorzoxazone in Rats with Diabetes: Induction of CYP2E1 on 6-Hydroxychlorzoxazone Formation
Keywords: پاکسازی ذاتی; CZX and OH-CZX; rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS); pharmacokinetics; CYP2E1; rats; disease state; CYP enzymes; metabolism; intrinsic clearance; protein binding;
In vitro–in vivo extrapolation of quantitative hepatic biotransformation data for fish : I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models
Keywords: پاکسازی ذاتی; Fish; Biotransformation; Intrinsic clearance; Kinetic models
Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases
Keywords: پاکسازی ذاتی; UDP-glucuronosyltransferases; LC/ESI/MS/MS; n-in-one cocktails; Intrinsic clearance;