
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
Keywords: HIV-1 integrase inhibitor; Bioisostere; Heteroaromatic carboxylic acid; Isoxazole; Isothiazole; 1H-Pyrazole; Bioavailability; Antiviral effect