دانلود مقالات ISI درباره چگونه، Janus kinase + ترجمه فارسی

فعال سازی مبدل سیگنال و فعال کننده رونویسی 3 در سلول های اندوتلیال غشاهای بیرونی هماتوم مزمن

Activation of Signal Transducer and Activator of Transcription 3 in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes

Keywords: چگونه، Janus kinase; Angiogenesis; Chronic subdural hematoma; STAT3CSDH, Chronic subdural hematoma; IL-6, Interleukin-6; JAK, Janus kinase; STAT, Signal transducer and activator of transcription; STAT3, Signal transducer and activator of transcription 3; VEGF, Vascular endoth

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

اثرات بیولوژیک اینترلوکین -6: کاربرد بالینی در بیماری های خودایمنی و سرطان

Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers

Keywords: چگونه، Janus kinase; IL-6, interleukin-6; JAK, Janus kinase; STAT, signal transducer and activator of transcription; PI3K, phosphoinositide 3-kinase; RA, rheumatoid arthritis; Th, T-helper; TNFα, tumor necrosis factor α; IFN, interferon; AKT/PKB, protein kinase B; NF-κB, nucl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

تغذیه دوز بالای اکسید روی، ساپرس کننده بیان ژن سیتوکین در گوسفندهای آلوده به سالمونلا تیفی موریوم را تحت تاثیر قرار می دهد

Feeding a high dosage of zinc oxide affects suppressor of cytokine gene expression in Salmonella Typhimurium infected piglets

Keywords: چگونه، Janus kinase; GALT, gut associated lymphatic tissue; JAK, janus kinase; SOCS, suppressor of cytokine signaling; STAT, signal transducers and activators of transcriptionSocs; Zinc oxide; Piglets; Salmonella Typhimurium

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

هورمون رشد بیان UCP2 در myocytes را تنظیم می کند

Growth hormone regulates the expression of UCP2 in myocytes

Keywords: چگونه، Janus kinase; AGHD, adult growth hormone deficiency; GH, growth hormone; GHR, growth hormone receptor; IGF-I, insulin-like growth factor-I; JAK, Janus kinase; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide-3 kinase; STAT, signal transduction and activat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination

Keywords: چگونه، Janus kinase; Hes3, Hairy and Enhancer of Split 3; MBP, myelin basic protein; NSC, neural stem cell; OPC, oligodendrocyte precursor cell; GFAP, Glial Fibrillary Acidic Protein; JAK, Janus kinase; STAT3, Signal Transducer and Activator of TranscriptionHes3; Myelin; Olig

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Response of the JAK-STAT signaling pathway to oxygen deprivation in the red eared slider turtle, Trachemys scripta elegans

Keywords: چگونه، Janus kinase; Anoxia; Oxidative stress; Hypometabolism; Low oxygenSTAT, signal transducer and activator of transcription; JAK, janus kinase; MAPK, mitogen activated protein kinase; SOCS, suppressors of cytokine signaling; PIAS, protein inhibitors of activated STAT; bcl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer

Keywords: چگونه، Janus kinase; JAK, Janus kinase; STAT, signal transducers and activators of transcription; EGFR, epidermal growth factor receptor; FLT3, FMS-like tyrosine kinase 3; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; NSCLC, non-small cell lung cancer; T

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases

Keywords: چگونه، Janus kinase; IFN, interferon; IFNA, interferon alpha gene; IFN-α, interferon α protein; IFNB, interferon beta gene; IFN-β, interferon β protein; SLE, systemic lupus erythematosus; IIM, idiopathic inflammatory myopathies; DC, dendritic cells; JAK, Janus kinase; STAT, s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Gene expression profiles predict the possible regulatory role of OPN-mediated signaling pathways in rat liver regeneration

Keywords: چگونه، Janus kinase; AKT, v-akt murine thymoma viral oncogene homolog 1; Bcl2, B-cell CLL/lymphoma 2; ERK, extracellular regulated protein kinases; Fos, FBJ osteosarcoma oncogene; IKBKB, inhibitor of κB kinase β; JAK, Janus kinase; JNK, c-Jun NH2-terminal kinase; Jun, jun pro

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Selective inhibition of JAK2/STAT1 signaling and iNOS expression mediates the anti-inflammatory effects of coniferyl aldehyde

Keywords: چگونه، Janus kinase; Coniferyl aldehyde; Anti-inflammatory activity; JAK2-STAT1; Nitric oxideCA, Coniferyl aldehyde; CRG, Carrageenan; ERK, Extracellular signal regulated kinase; IFN, Interferon; iNOS, Inducible nitric oxide synthase; JAK, Janus kinase; JNK, Jun amino termina

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Signaling via the CytoR/JAK/STAT/SOCS pathway: Emergence during evolution

Keywords: چگونه، Janus kinase; CHD, cytokine receptor homology domain; CytoR, cytokine receptor; EST, expressed sequence tag; FBN, fibronectin; FERM, four-point-one, ezrin, radixin, moesin; HP, heterochromatin protein; Ig, immunoglobulin; JAK, Janus kinase; SH2, Src-homology 2; SOCS, s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors

Keywords: چگونه، Janus kinase; STAT3, signal transducers and activators of transcription 3; IL-6, interleukin-6; JAK, Janus kinase; SAR, structure–activity relationshipsSTAT3 signaling pathway; Inhibitors; Benzyloxyphenyl-methylaminophenol derivatives; Structure–activity relationship

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Novel Cosic resonance (standing wave) solutions for components of the JAK–STAT cellular signaling pathway: A convergence of spectral density profiles

Keywords: چگونه، Janus kinase; BCLxl, B-cell lymphoma-extra large; CASP-9, caspase 9; cSrc, cellular Src kinase; EIIP, pseudopotential of electron–ion interaction; Il, interleukin; JAK, Janus Kinase; PBS, phosphate buffered saline; RRM, Resonance Recognition Model; SPD, spectral power

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren׳s syndrome patients, in salivary duct epithelial cells

Keywords: چگونه، Janus kinase; IFN, interferon; IL, interleukin; JAK, Janus kinase; MSG, minor salivary glands; SS, Sjögren׳s syndrome; STAT, signal transducer and activator of transcriptionRegenerating gene; Interleukin-6; Sjögren׳s syndrome; Janus kinase; Signal transducer and activa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Unsaturated but not saturated fatty acids induce transcriptional regulation of CCL2 in pancreatic acini. A potential role in acute pancreatitis

Keywords: چگونه، Janus kinase; AP, acute pancreatitis; CCL2, chemokine (C–C motif) ligand 2; ERK, extracellular signal-regulated kinase; FA, fatty acid; JAK, Janus kinase; JNK, Jun NH2-terminal kinase; LA, linoleic acid; MAPKs, mitogen-activated protein kinases; NF-κB, nuclear factor-k

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Erythropoietin acts as an anti-inflammatory signal on murine mast cells

Keywords: چگونه، Janus kinase; BMMC, bone marrow-derived mast cells; Epo, erythropoietin; JAK, Janus kinase; LPS, lipopolysaccharide; SCF, stem cell factor; SOCS, suppressor of cytokine signaling; STAT, signal transducer and activator of transcription; TNF, tumor necrosis factor; TPR,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Type I interferon receptors in goose: Molecular cloning, structural identification, evolutionary analysis and age-related tissue expression profile

Keywords: چگونه، Janus kinase; IFN, interferon; IFNAR1, interferon-α receptor α-chain; IFNAR2, interferon-α receptor β-chain; JAK, Janus kinase; STAT, signal transducers and activators of transcription; ISGs, interferon stimulated genes; cDNA, complementary to RNA; RACE, rapid amplific

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis 12

Keywords: چگونه، Janus kinase; IL6, interleukin-6; JAK, Janus kinase; STAT3, signal transducer and activator of transcription 3; PI3K, phosphoinositide 3-kinase; MAPK, mitogen activated protein kinase; LFABP, liver fatty acid binding protein; RS6K, ribosomal S6 kinase; HCC, hepatocellu

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer

Keywords: چگونه، Janus kinase; HRP, horseradish peroxidase; JAK, Janus kinase; PCNA, proliferating cell nuclear antigen; PI, propidium iodide; STAT, signal transducer and activator of transcription; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labelingApoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes

Keywords: چگونه، Janus kinase; PCBs, polychlorinated biphenyls; NDL, non-dioxin-like; AT, adipose tissue; POPs, persistent organic pollutants; iPCBs, indicator PCBs; Jak, Janus kinase; STAT, signal transducers and activated transcription; DMSO, dimethyl sulfoxide; FBS, fetal bovine ser

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Toward a new STATe: The role of STATs in mitochondrial function

Keywords: چگونه، Janus kinase; STAT, Signal Transducer and Activator of Transcription; JAK, Janus kinase; TFs, transcription factors; ETC, electron transport chain; MLS, mitochondrial localization sequence; MTS, mitochondrial targeting sequence; MEFs, mouse embryonic fibroblasts; KO, k

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Characterization of a novel growth hormone receptor-encoding cDNA in rainbow trout and regulation of its expression by nutritional state

Keywords: چگونه، Janus kinase; Akt, protein kinase B; Bp, base pair; cDNA, DNA complementary to RNA; CT, threshold cycle number; ERK, extracellular signal-regulated kinase; FSGD, fish specific genome duplication; GH, growth hormone; GHR, growth hormone receptor; JAK, janus kinase; mRNA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

A perylene derivative regulates HIF-1α and Stat3 signaling pathways

Keywords: چگونه، Janus kinase; HIF-1, hypoxia-inducible factor-1; STAT, signal transducer and activator of transcription; SRC, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; JAK, Janus kinase; ERK, extracellular signal-regulated protein kinases; AKT, serine/threonine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Differential intracellular signalling properties of the growth hormone receptor induced by the activation of an anti-GHR antibody

Keywords: چگونه، Janus kinase; hGH, human growth hormone; GHR, growth hormone receptor; mAb, monoclonal antibody; FITC, fluorescein isothiocyanate; PBS, phosphate-buffered saline; TMB, tetramethylbenzidine; JAK, Janus kinase; STAT, signal transducers and activators of transcription; MA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro

Keywords: چگونه، Janus kinase; APC, antigen presenting cells; CFSE, 5,6 carboxyfluorescein diacetate, succinimidyl ester; DC, dendritic cell; HDAC, Histone deacetylases; HPC, hematopoietic progenitor cell; IDO, indoleamine 2,3-dioxygenase; IMC, immature myeloid cell; JAK, Janus kinase;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host–microbial mutualism

Keywords: چگونه، Janus kinase; AID, activation-induced (cytidine) deaminase; Ag, antigen; ERK, extracellular receptor kinase; IgA, immunoglobulin A; IBD, inflammatory bowel disease; IFN, interferon; IRF, interferon regulatory factor; IL, interleukin; JAK, Janus kinase; LPS, lipopolysac

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling

Keywords: چگونه، Janus kinase; bp, base pair; JAK, Janus kinase; Tyk2, tyrosine kinase 2; IFN, interferon; JAB, JAK-binding protein; SH2, SRC-homology 2; ESS, extended SH2 domain; KIR, kinase inhibitory region; SOCS, suppressors of cytokine signaling; STAT, signal transducers and activ

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients

Keywords: چگونه، Janus kinase; HCV, hepatitis C virus; NS, non-structural; TCPTP, T cell protein tyrosine phosphatase; IFN, interferon; EGFR, epidermal growth factor receptor; Jak, janus kinase; STAT, signal transducer and activator of transcription; GAPDH, glyceraldehyde 3-phosphate d

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation

Keywords: چگونه، Janus kinase; ɛ Germline transcript; IgE; Pentagalloylglucose; Signal transducers and activators of transcription6; Tannic acidɛGT, ɛ germline transcript; IFN-γ, interferon-gamma; IgE, immunoglobulin E; IL, interleukin; JAK, Janus kinase; OVA, ovalbumin; PGG, 1,2,3,4,6

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The role of human growth hormone's C-terminal disulfide bridge

Keywords: چگونه، Janus kinase; (h)GH, (human) growth hormone; wt, wild type; HEK, human embryonic kidney; GHR, GH receptor; GHBP, GH binding protein; GHRH, GH releasing hormone; SST, somatostatin; IGF, insulin-like growth factor; Jak, Janus kinase; STAT, signal transducer and activator

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor

Keywords: چگونه، Janus kinase; Akt, a member of serine–threonine kinase family; AP-1, activator protein 1; Cdc 42, cell division cycle 42; Erk1/2, extracellular signal-regulated kinases 1/2; IRAKs, IL-1R associated kinases; JAK, Janus kinase; JNK, Jun N-terminal kinase; m-Dia 1, mammal

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance

Keywords: چگونه، Janus kinase; SOCS7 (suppressor of cytokine signaling, 7); Insulin resistance; tagSNPs; InflammationSOCS, suppressor of cytokine signaling; IR, insulin resistance; DM2, type 2 diabetes; MS, metabolic syndrome; JAK, janus kinase; STAT, signal transducer and activator of

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (SOCS) in macrophages: Implications for the hosts’ innate immune response

Keywords: چگونه، Janus kinase; ABCE1, ATP-binding cassette, sub-family E protein; IFNα, interferon alpha; IFNβ, interferon beta; IFIT1, interferon-induced protein with tetratricopeptide repeats 1; IRF, interferon regulatory transcription factor; JAK, janus kinase; JEV, Japanese encepha

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

A chimeric cyclic interferon-α2b peptide induces apoptosis by sequential activation of phosphatidylinositol 3-kinase, protein kinase Cδ and p38 MAP kinase

Keywords: چگونه، Janus kinase; DNp38, dominant-negative p38 mutant; DNp85, dominant negative mutant of p85 PI3K-regulatory subunit; IFN-α2b, interferon-α2b; FBS, fetal bovine serum; Jak, Janus kinase; MAPK, mitogen-activated protein kinase; MEM, minimum essential medium; PI3K, phosphat

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

The U-box-type ubiquitin ligase PRP19β regulates astrocyte differentiation via ubiquitination of PTP1B

Keywords: چگونه، Janus kinase; cAMP, N6,2-O-dibutyryl cyclic AMP; GAPDH, glyceraldehyde 3′-phosphate dehydrogenase; GFAP, glial fibrillary acidic protein; IL-6, interleukin-6; JAK, Janus kinase; PTP1B, protein tyrosine phosphatase 1B; RA, retinoic acid; SHP2, Src homology domain 2 (SH2

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Liquid chromatography–tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma

Keywords: چگونه، Janus kinase; HESI, heated electrospray ionization; JAK, Janus kinase; LLOQ, lower limit of quantification; SRM, selected reaction monitoring; QC, quality controlCYT387; JAK2 inhibitor; LC–MS/MS; Human plasma; Mouse plasma

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients

Keywords: چگونه، Janus kinase; cDNA, complementary DNA; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HCV, hepatitis C virus; IFN, interferon; ISG, interferon-stimulated gene; JAK, janus kinase; mRNA, messenger RNA; PEG, pegylated; PIAS, protein inhibitors of activated STATs; PKR, R

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis

Keywords: چگونه، Janus kinase; AD, atopic dermatitis; DN, dominant negative; FBS, fetal bovine serum; Jak, Janus kinase; Stat, signal transducer and activator of transcription; TBS, Tris-buffered saline; Tg, transgenicIL-4; CCL26; Gene regulation; Atopic dermatitis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Thymic stromal lymphopoietin and allergic disease

Keywords: چگونه، Janus kinase; Thymic stromal lymphopoietin; asthma; allergy; atopic dermatitis; inflammationAD, Atopic dermatitis; AR, Allergic rhinitis; DC, Dendritic cell; FITC, Fluorescein isothiocyanate; IL-7R, IL-7 receptor; JAK, Janus kinase; LC, Langerhans cell; LEKTI, Lymphoep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Novel systemic drugs under investigation for the treatment of psoriasis

Keywords: چگونه، Janus kinase; biologics; clinical trials; psoriasis; small molecule inhibitorsIFN, interferon; IL, interleukin; JAK, Janus kinase; PASI, Psoriasis Area Severity Index; PASI-75, at least 75% reduction in clinical severity as measured by Psoriasis Area Severity Index sco

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacology and therapeutic potential of interferons

Keywords: چگونه، Janus kinase; ET-1, endothelin 1; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; IFN, interferon; IP10, interferon gamma induced protein 10; ISG, interferon stimulated gene; JAK, Janus kinase; MS, multiple sclerosis; PAH, pulmonary a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy

Keywords: چگونه، Janus kinase; CNTF, ciliary neurotrophic factor; Ct, threshold cycle; DAPI, 4′,6-diamidino-2-phenylindole; FR, fast ripple; GCD, granule cell dispersion; GCL, granule cell layer; GFAP, glial fibrillary acidic protein; JAK, janus kinase; KA, kainate; LFP, local field po

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular regulation of interferon antiviral response in fish

Keywords: چگونه، Janus kinase; IFN, interferon; IRF, interferon regulatory factor; IRSE, interferon stimulated response element; ISG, IFN stimulated gene; IKKε, inhibitor of kappaB kinase epsilon; ISGF3, interferon-stimulated gene factor 3; Jak, Janus kinase; Stat, signal transducer an

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells

Keywords: چگونه، Janus kinase; Enzyme inhibitor; Diabetes mellitus; Obesity; Protein tyrosine phosphatase; Insulinomimetic agent; Molecular dockingDM2, type 2 diabetes mellitus; 2-DOG, 2-deoxyglucose; IR, insulin receptor; IRS, insulin receptor substrate; JAK, Janus kinase; LMW-PTP, lo

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells

Keywords: چگونه، Janus kinase; Sal B, salvianolic acid B; IFN-γ, interferon-γ; IP-10, IFN-inducible protein of 10 kDa; STATs, signal transducers and activators of transcription; JAK, Janus kinase; PIAS, protein inhibitor of activated STAT; SOCS, suppressor of cytokine signaling; ECs, e

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Role of suppressor of cytokine signaling 3 in lipid metabolism: Analysis based on a phage-display human liver cDNA library

Keywords: چگونه، Janus kinase; FAO, fatty acid oxidation; JAK, Janus Kinase; OB-R, leptin receptor; MPBS, PBS containing 4% skimmed milk powder; SOCS, suppressor of cytokine signaling; TC, total cholesterol; TG, triglyceride; VLCAD, very-long-chain acyl-CoA dehydrogenaseObesity; Suppre

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Impact of SOCS3 overexpression on human skeletal muscle development in vitro

Keywords: چگونه، Janus kinase; BSA, bovine serum albumin; Ct, critical threshold; ECM, extracellular matrix; FBS, fetal bovine serum; FGF, fibroblast growth factor; HS, horse serum; JAK, Janus kinase; MEM, minimum essential media; RT-PCR, real time-PCR; SOCS, suppressors of cytokine si

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells

Keywords: چگونه، Janus kinase; IFNα, interferon alpha-2b; CYP, cytochrome P450; RT-PCR, reverse-transcription polymerase chain reaction; JAK, Janus kinase; STAT, signal transducer and activator; RLU, relative luciferase unit; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrop

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox

Keywords: چگونه، Janus kinase; CIS, cytokine-induced SH2 protein; EICs, extracted ion chromatograms; IL-6, interleukin 6; JAK, Janus kinase; LC/MS–ITTOF, high-performance liquid chromatography combined with hybrid ion trap/time-of-flight; MDA, malondialdehyde; MEQ, mequindox; ROS, reac

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Interleukin 15 as a promising candidate for tumor immunotherapy

Keywords: چگونه، Janus kinase; ADCC, antibody-dependent cellular cytotoxicity; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; JAK, Janus kinase; LPS, lipopolisaccharide; NK, natural killer; NKT, natural killer T cell; PD-1, programmed death-1; STAT, signal t

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه