Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders
Keywords: KATII; RapidFire; Mass spectrometry; Fluorescence; High throughputKYNA, kynurenic acid; CNS, central nervous system; KAT, kynurenine aminotransferase; PLP, pyridoxal-5'-phosphate; KYN, kynurenine; S-ESBA, (S)-4-(ethylsulfonyl)benzoylalanine; hKATII, human