دانلود مقالات ISI درباره kDNA، DNA Kinetoplast + ترجمه فارسی

Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

Keywords: kDNA، DNA Kinetoplast; Flavonoids; Pyrido[1,2-a]pyrimidin-4-ones; Scaffold-hopping; Human topoisomerase IIα; Anticancer agent; Drug discoveryhTopoIIα, Human topoisomerase IIα; kDNA, Kinetoplast DNA; Nck, Nicked; Rel, Relaxed; Lin, Linear; SC, Supercoiled; TAE, Tris-acetate-EDTA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

Keywords: kDNA، DNA Kinetoplast; Top, DNA topoisomerase; CL, cutaneous leishmaniasis; VL, visceral leishmaniasis; DALYs, disability-adjusted life years; kDNA, kinetoplast DNA; NTD, neglected tropical diseases; NGO, non-governmental organization; lk, linking number; NLS, Nuclear Localizat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Structural determinants of the catalytic inhibition of human topoisomerase IIα by salicylate analogs and salicylate-based drugs

Keywords: kDNA، DNA Kinetoplast; 2-FBA, 2-fluorobenzoate; 2-MBA, 2-methylbenzoate; 5-ASA, 5-aminosalicylic acid; ASA, acetylsalicylic acid; DHBA, dihydroxybenzoate; HBA, hydroxybenzoate; ICE, in vivo complex of enzyme; kDNA, kinetoplast DNA; topo II, topoisomerase II; THBA, trihydroxyben

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation

Keywords: kDNA، DNA Kinetoplast; Oxo-heterocyclic; Naphthalimides; Antitumor agents; Topo I; Topo II; DNA intercalationCD, circular dichroism; CPT, camptothecin; ctDNA, calf thymus DNA; kDNA, kinetoplast DNA; SAR, structure–activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

Keywords: kDNA، DNA Kinetoplast; A431, human epidermoid carcinoma cell line; kDNA, kinetoplast DNA; MCF-7, human breast adenocarcinoma cell line; ETO, etoposide; DMSO, dimethyl sulfoxideLycobetaine; Phenanthridines; N-Methylphenanthridinium chlorides; DNA-topoisomerase; Structure–activit

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs)

Keywords: kDNA، DNA Kinetoplast; Angiogenesis; Multitarget; Naphthalimide; Topoisomerase II; Tyrosine kinaseEGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; HMEC-1, Human Microvascular Endothelial Cells; kDNA, kinetoplast DNA; PDGFR, platelet-derived growt

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Trypanosoma rangeli genotypes association with Rhodnius prolixus and R. pallescens allopatric distribution in Central America

Keywords: kDNA، DNA Kinetoplast; SL, splicer leader gene; SSU rRNA, small subunit of ribosomal RNA; kDNA, kinetoplast DNA; RAPD, random amplified polymorphic DNATrypanosoma rangeli KP1(+); Trypanosoma rangeli KP1(−); RAPD; kDNA; Mini-exon gene; Co-evolution; Interaction parasite-vector;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Selective amplification of maxicircle classes during the life cycle of Leishmania major

Keywords: kDNA، DNA Kinetoplast; FBS, foetal bovine serum; kDNA, kinetoplast DNA; NNN, Novy–Nicolle–MacNeal mediumLeishmania; Life cycle; Maxicircle; Divergent region; Heteroplasmy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome

Keywords: kDNA، DNA Kinetoplast; m-AMSA, amsacrine; TL, trypsin-like; PGPH, peptidyl glutamyl peptide hydrolase; CTL, chymotrypsin-like; kDNA, kinetoplast DNA; CPI, calpain peptide inhibitor; RFU, relative fluorescence unit; RLU, relative luminescence unit; HIV, human immunodeficiency vi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

The Leishmania major maxicircle divergent region is variable in different isolates and cell types

Keywords: kDNA، DNA Kinetoplast; CSB-I, -II, -III, conserved sequence blocks-I, -II, -III; DR, divergent region; gRNA, guide RNA; kDNA, kinetoplast DNA; rI; rII, type I or type II repeatsLeishmania; Maxicircle; Divergent region; Conserved sequence; Variability

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Application of kDNA as a molecular marker to analyse Leishmania infantum diversity in Portugal

Keywords: kDNA، DNA Kinetoplast; PCR, polymerase chain reaction; kDNA, kinetoplast DNA; RFLP, restriction fragment length polymorphism; bp, base pairs; TAE, Tris-acetate EDTA.Leishmania infantum; Epidemiology; Portugal; PCR-RFLP

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

DNA topoisomerase I from parasitic protozoa: A potential target for chemotherapy

Keywords: kDNA، DNA Kinetoplast; LdTOPIA, gene encoding the large subunit of L donovani topoisomerase I; LdTOPIB, gene encoding the small subunit of L donovani topoisomerase; PfTOPI, gene encoding P. falciparum topoisomerase I; NLS, nuclear localization signal; kDNA, kinetoplast DNA; Tdp

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه