Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy
Keywords: VEGF, vascular endothelial growth factor; hVEGF, human VEGF; VEGFR1, VEGF receptor 1; VEGFR2, VEGF receptor 2; KDR, kinase insert domain-containing receptor; Flt-1, fms-like tyrosine kinase; Mab, monoclonal antibody; scFv, single chain Fv antibody fragmen