Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone
Keywords: AC; adenylyl cyclase; β-FNA; β-funaltrexamine; cAMP; cyclic AMP; CTX-B; cholera toxin-B subunit; GM1; monosialoganglioside; IBMX; 3-isobutyl-1-methylxanthine; NLX; naloxone; NTX; naltrexone; nor-BNI; nor-binaltorphimine; PDE; phosphodiesterase; PKA; pro