دانلود مقالات ISI درباره می تواند + ترجمه فارسی

پیامدهای ملانین در تحویل دارو چشم

Implications of melanin binding in ocular drug delivery

Keywords: می تواند; Bmax; maximum binding capacity; CNV; choroidal neovascularization; DCT; dopachrome tautomerase; DHI; 5,6-dihydroxyindole; DHICA; 5,6-dihydroxyindole-2-carboxylic acid; DOPA; dihydroxyphenylalanine; HPLC; high performance liquid chromatography; IQ; 5,6-ind

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

توانایی درونی را دوباره مشاهده کنید - هدف را در چشم خود نگه دارید

In vivo potency revisited - Keep the target in sight

Keywords: می تواند; Bmax; total density of receptors/targets in a sample tissue; L; free ligand concentration; In; input of ligand; Cl(L); non-specific unbound ligand clearance; Ctot; total concentration of ligand (free and ligand bound non-specifically to e.g., plasma prote

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

دینامیک دوپامین هیپوتیوتیک در مانیا و روان درمانی - پیامدهای فارماکوکینتیک آن است

Hypothetical dopamine dynamics in mania and psychosis - its pharmacokinetic implications

Keywords: می تواند; CO; competitive inhibitor; [D]; molar concentration of antipsychotics in the extracellular fluid; DAT; dopamine transporter; D2R; dopamine D2 receptor; D2H; high-affinity D2R; D2L; low-affinity D2R; EC50; half-maximal effective concentration; Kd; dissocia

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat

Keywords: می تواند; Bmax; concentration of total D2 binding site in striatum; ECF; extracellular fluid; IV; intravenous; Kd; drug affinity to the receptor; koff; drug dissociation rate from the receptor; kon; drug association rate to the receptor; PET; positron emission tomo

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor

Keywords: می تواند; CB1; cannabinoid type 1 receptor; FRET; fluorescence resonance energy transfer; GPCRs; G protein-coupled receptors; HD; Huntington's disease; TM; transmembrane; G-proteins; GTP binding-proteins; cAMP; cyclic adenosine monophosphate; ERK1/2; extracellula

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Minimal physiologically-based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti-VEGF humanized IgG1 antibody in cynomolgus monkey

Keywords: می تواند; AIC; Akaike Information Criterion; ATA; anti-therapeutic antibody; AUC; area under the curve; CLe; antibody clearance in endothelial space; CDP; Complex Dedrick Plot; CV; coefficient of variations; FR; recycling fraction of IgG; F1; modulation factor of m

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Recombinant humanized anti-vascular endothelial growth factor monoclonal antibody efficiently suppresses laser-induced choroidal neovascularization in rhesus monkeys

Keywords: می تواند; AMD; age-related macular degeneration; CNV; choroidal neovascularization; VEGF; vascular endothelial growth factor; MAb; monoclonal antibody; VA; visual acuity; Kon; association rate; Kdis; dissociation rate; KDR; VEGF receptor-2; OD; optical density; IC5

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of an over-ground exoskeleton on external knee moments during stance phase of gait in healthy adults

Keywords: می تواند; KOA; Knee osteoarthritis; KAM; Knee adduction moment; CoP; Center of pressure; KJC; Knee joint center; F; Ground reaction force; T; Ground reaction (twist) torque; R; External knee moment arm (lab frame); M/M′; External knee moment (lab frame/tibia fram

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Engineering nitric oxide synthase chimeras to function as NO dioxygenases

Keywords: می تواند; Arg; l-arginine; DTT; dithiothreitol; NO; nitric oxide; EPPS; 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid; NOHA; Nω-hydroxy-l-arginine; H4B; (6R)-5, 6, 7, 8-tetrahydro-l-biopterin; FMN; flavin mononucleotide; FAD; flavin adenine dinucleotide; NAD

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells

Keywords: می تواند; 2AB; 2-aminobenzamide; ALCAM; Activated leukocyte cell adhesion molecule; ALCAMe; Endogenous ALCAM from MDA-MB-231 cells; ALCAMgly; Recombinant glycosylated ALCAM expressed in HEK-293 cells; ALCAMnongly; Non-glycosylated ALCAM; ADAM17; A disintegrin and m

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist

Keywords: می تواند; PAR1; protease activated receptor 1; huCASMC; human coronary artery smooth muscle cells; HCl; hydrochloric acid; MgCl2; magnesium chloride; CaCl2; calcium chloride; NaCl; sodium choride; KCl; potassium chloride; K2HPO4; dipotassium phosphate; EGTA; ethyle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides

Keywords: می تواند; BLI; bio-layer interferometry; BMDCs; bone marrow dendritic cells; DCs; dendritic cells; EDC; 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride; imBMDCs; immature BMDCs; KD; affinity constant; kdis; dissociation constant; kon; association consta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists

Keywords: می تواند; Residence time; Structure-affinity relationships; Structure-kinetics relationships; Adenosine A1 receptor; Extracellular loops; ADA; adenosine deaminase; Ac; acetyl; BCA; bicinchoninic acid; BEDROC; Boltzmann-enhanced discrimination of receiver-operating

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: Molecular modeling with biological evaluation

Keywords: می تواند; 15d-PGJ2; 15-deoxy-Δ12,14-PGJ2; AA; arachidonic acid; PPARγ; peroxisome proliferator-activated receptor γ; FXR; farnesoid X receptor; SPR; surface plasmon resonance; FQ; fluorescence quenching; HTRF; homo time-resolved fluorescence; BSEP; bile-salt exp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells

Keywords: می تواند; APL; altered peptide ligand; CAb; clonotypic Ab for n3.L2 TCR; DN; double negative thymocytes; DP; double positive thymocytes; Hb; hemoglobin; koff; off-rate constant; kon; on-rate constant; MHCII; MHC class II; pMHC; peptide MHC complex; scTCR; single ch

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Regular ArticleThe inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives

Keywords: می تواند; ECM; extracellular matrix; EDC; N-ethyl-N-(dimethylaminopropyl)-carbodiimide; FCS; fetal calf serum; HRP; horseradish peroxidase; KD; equilibrium dissociation constant; koff; dissociation rate constant (off-rate); kon; association rate constant (on-rate);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

Keywords: می تواند; ANOVA; analysis of variance; BDM; 2,3-butanedione monoxime; cTn; cardiac troponin; cTnC; cardiac troponin C; cTnI; cardiac troponin I; cTnT; cardiac troponin T; dATP; 2-deoxy-ATP; DTT; dithiothreitol; fapp; rate of cross-bridges transitioning into tension

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Partial hydrolysis enhances the inhibitory effects of konjac glucomannan from Amorphophallus konjac C. Koch on DNA damage induced by fecal water in Caco-2 cells

Keywords: می تواند; FF, fibre-free; KGM, konjac glucomannan; DP, degree of polymerisation; F1 and F2, fractions 1 and 2; FPG, formamidopyrimidine DNA glycosylase; C. perfringens, Clostridium perfringensDietary fibre; Amorphophallus konjac C. Koch; Araceae; Oligofructose; Kon

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Probing hydrogen peroxide oxidation kinetics of wild-type Synechocystis catalase-peroxidase (KatG) and selected variants

Keywords: می تواند; KatG; catalase-peroxidase; BLC; bovine liver catalase; PAA; peroxoacetic acid; RFQ-EPR; rapid freeze-quench electron paramagnetic resonance; HS; high-spin, LS, low-spin; 5-c; five coordinated; 6-c; six coordinated; kon; apparent bimolecular rate constant

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states

Keywords: می تواند; AChR; nicotinic acetylcholine receptor; NCA; noncompetitive antagonist; PCP; phencyclidine; [3H]TCP; [piperidyl-3,4-3H(N)]-(N-(1-(2 thienyl)cyclohexyl)-3,4-piperidine); Ibogaine (or 12-methoxyibogamine); 7-ethyl-6,2,7,8,9,10,12,13-octahydro-2-methoxy-6,9-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Roles of two surface residues near the access channel in the substrate recognition by cytochrome P450cam

Keywords: می تواند; WT; Wild type enzyme; P450cam; Cytochrome P450cam (CYP101) from Pseudomonas putida, which catalyzes the hydroxylation of 1R-camphor; P450f; Cytochrome P450 camphor-free form; P450b; Cytochrome P450 camphor-bound form; kon; Camphor association constant; ko

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Measurement of the functional affinity constant of a monoclonal antibody for cell surface receptors using kinetic exclusion fluorescence immunoassay

Keywords: می تواند; KinExA; kinetic exclusion assay; ELISA; enzyme-linked immunosorbent assay; hIGFR; human insulin-like growth factor I receptor; NHS-PMMA beads; N-hydroxysuccinimide-polymethyl methacrylate beads; NSB; non-specific binding; Kd; equilibrium dissociation co

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه