Keywords: LC، زنجیره سبک; BME, 2-mercaptoethanol; CDR, complementary determining regions; CMC, critical micelle concentration; HC, heavy chain; IAM, iodoacetamide; LC, light chain; mAb, monoclonal antibody; NGHC, non-glycosylated heavy chain; PNGase F, peptide N-glycosidase F; TCE
مقالات ISI LC، زنجیره سبک (ترجمه نشده)
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Keywords: LC، زنجیره سبک; Botulinum neurotoxins; Endogenous substrate cleavage; Combinational uses; Therapeutic applicationBoNTs, Botulinum Neurotoxin; LC, light chain; LC/T, light chain of Tetanus neurotoxin; VAMP2, vesicle associated membrane protein-2; SNAP25, Synaptosomal-asso
Keywords: LC، زنجیره سبک; BoNT, botulinum toxin; CGRP, calcitonin gene related peptide; CSA, cutaneous sensory afferents; DRG, dorsal root ganglion; HC, heavy chain; IPLT, intraplanatar; LC, light chain; MSA, meningeal sensory afferents; NK-1, neurokinin; SNARE, soluble N-ethylale
Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes
Keywords: LC، زنجیره سبک; Botulinum neurotoxin E; Expression; Solubility; SubtypesBoNT, Botulinum neurotoxins; LC, light chain; HC, heavy chain; HCT, translocation domain; HCR, receptor binding domain
Comparative characterization of botulinum neurotoxin subtypes F1 and F7 featuring differential substrate recognition and cleavage mechanisms
Keywords: LC، زنجیره سبک; Botulinum neurotoxin serotype F; Substrate recognition; F1; F7; MechanismCNTs, clostridia neurotoxins; BoNT, botulinum neurotoxin; LC, light chain; VAMP2, vesicle associated membrane protein-2; SNARE, soluble NSF attachment receptor
In vitro generation of rabbit anti-Listeria monocytogenes monoclonal antibody using single cell based RT-PCR linked cell-free expression systems
Keywords: LC، زنجیره سبک; ELISA, enzyme-linked immunosorbent assay; SICREX, single-cell reverse transcription-PCR linked in vitro-expression; CFPS, cell-free protein synthesis; Hc, heavy chain; Lc, light chain; RT, room temperature; SA beads, DynaBeads M-280 Streptavidin; Fab, fra
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
Keywords: LC، زنجیره سبک; BoNT, botulinum neurotoxin; HC, heavy chain; HC, carboxyl-terminal half of HC; HN, amino-terminal half of HC; LC, light chain; SV2, synaptic vesicle glycoprotein 2; Syt, synaptotagmin; Syp, synaptophysin; Syo, Synaptoporin; Syg, SynaptogyrinBotulinum neur
Gene expression measurements normalized to cell number reveal large scale differences due to cell size changes, transcriptional amplification and transcriptional repression in CHO cells
Keywords: LC، زنجیره سبک; CCI, cell cycle inhibitor; CHO, Chinese Hamster Ovary; ERCC, External RNA Controls Consortium; HC, heavy chain; IRES, Internal Ribosome Entry Site; LC, light chain; mTOR, mammalian target of rapamycin; mTORI, mTOR inhibitor; qP, specific productivity; qPC
Botulinum toxin A, brain and pain
Keywords: LC، زنجیره سبک; BoNT/A, botulinum toxin type A; LC, light chain; SV2, synaptic vesicle protein 2; SNAP-25, synaptosomal-associated protein of 25 kDa; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; VAMP, vesicle-associated membrane protein;
Protein–protein interactions between intermediate chains and the docking complex of Chlamydomonas flagellar outer arm dynein
Keywords: LC، زنجیره سبک; BMH, bismaleimidohexane; IC, intermediate chain; LC, light chain; OAD, outer arm dynein; ODA-DC, outer dynein arm docking complexDynein; Cilia; Flagella; Microtubule; Chlamydomonas
Distinct processing of the pre-B cell receptor and the B cell receptor
Keywords: LC، زنجیره سبک; BCR, B-cell receptor; Endo H, endoglycosidase H; ER, endoplasmic reticulum; Ig, immunoglobulin; HC, heavy chain; LC, light chain; SLC, surrogate light chainB cell receptor; pre-B cell receptor; Receptor internalization; Intracellular protein trafficking
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity
Keywords: LC، زنجیره سبک; BoNT, botulinum neurotoxin; HC, heavy chain; HC, carboxyl-terminal half of HC; HCC, carboxyl-terminal half of HC; HCN, amino-terminal half of HC; HN, amino-terminal half of HC; LC, light chain; SV2, synaptic vesicle glycoprotein 2; hSyt, mSyt, rSyt, human
MAP1B 1–126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons
Keywords: LC، زنجیره سبک; Aß, ß-amyloid; AD, Alzheimer disease; DIV, days in vitro; GST, glutathione-S-transferase; HC, heavy chain; LC, light chain; MAP1B, microtubule associated protein 1B; NFT, neurofibrillary tangleMAP1B; Microtubule binding; Neuronal death; Caspase
Primary sequence determination of a monoclonal antibody against α-synuclein using a novel mass spectrometry-based approach
Keywords: LC، زنجیره سبک; SILAC, stable isotope labeled amino acids in cell culture; CID, collision induced dissociation; HCD, higher-energy collisiondissociation; CDR, complementary determining region; HC, heavy chain; LC, light chain; MALDI, matrix-assisted laser desorption/ioni
Calcium regulation of the ATPase activity of Physarum and scallop myosins using hybrid smooth muscle myosin: The role of the essential light chain
Keywords: LC، زنجیره سبک; HMM, heavy meromyosin; SmHMM·HC, smooth muscle HMM heavy chain; ABSF, 4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride; HC, heavy chain; LC, light chain; ScRLC, scallop regulatory light chain; ScELC, scallop essential light chain; PhRLC, Physarum r
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway
Keywords: LC، زنجیره سبک; BSA, bovine serum albumin; ER, endoplasmic reticulum; FFA, free fatty acids; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LC, light chain; 3-MA, 3-methyadenine; mTOR, mammalian target of rapamycin; NAC, N-acetylcysteine; 4PBA, 4-phenylbutyric acid; PK
The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity
Keywords: LC، زنجیره سبک; Clostridial botulinum neurotoxins; Botulinum neurotoxin serotype A; Fluorescence resonance energy transfer; High-throughput screening assay; Small molecular inhibitors; primary neuron-based assayBoNT/A, botulinum neurotoxin serotype A; LC, light chain; HC
Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases
Keywords: LC، زنجیره سبک; VHH; Nanobody; Intrabody; Botulinum; Neurotoxin; BoNT; MetalloproteinaseHcAbs, heavy chain only antibodies; VHH, heavy chain only VH domain; BoNT, botulinum neurotoxin; Lc, light chain; SNARE, soluble NSF attachment protein; GST, glutathione-S-transferase
A Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring λ6 Light-Chain Fibrillogenesis
Keywords: LC، زنجیره سبک; ASU, asymmetric unit; BJ, Bence–Jones; CDR, complementarity-determining region; FR, framework region; LC, light chain; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; ThT, thioflavin T; VL, variable region of the light chain; WT, wild type
The Effect of Membranes on the In Vitro Fibrillation of an Amyloidogenic Light-Chain Variable-Domain SMA
Keywords: LC، زنجیره سبک; SUV, small unilamellar vesicle; LUV, large unilamellar vesicle; ATR-FTIR, attenuated total reflectance Fourier-transform infrared spectroscopy; ThT, thioflavin T; EM, electron microscopy; LC, light chain; PC, phosphatidylcholine; PE, phosphatidylethanolam
Role of two active site Glu residues in the molecular action of botulinum neurotoxin endopeptidase
Keywords: LC، زنجیره سبک; BoNT, botulinum neurotoxin; LC, light chain; SNAP-25, synaptosomal associated protein of 25 kDa; VAMP, vesicle-associated membrane protein; SNARE, soluble NSF attachment protein receptor; NaPB, sodium phosphate buffer; CD, circular dichroism; PCR, polymer
Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
Keywords: LC، زنجیره سبک; BsAb, Bispecific antibody; HRP, horse radish peroxidase; HC, heavy chain; LC, light chain; mPDGFRα, mouse PDGF receptor α; mPDGFRβ, mouse PDGF receptor β; PBS, phosphate buffered saline; PDGF, platelet derived growth factor; RT, room temperature; sVD, sin
The κ-like pre-B receptor: Surplus biology or a missing link?
Keywords: LC، زنجیره سبک; Ag, antigen; BCR, B cell receptor; Ig, immunoglobulin; HC, heavy chain; LC, light chain; SLC, surrogate light chains; V(D)J, variable diversity joiningB-lymphocytes; Development; Immunoglobulin genes; Surrogate light chains; Bone marrow stroma
Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains
Keywords: LC، زنجیره سبک; HRP, horse radish peroxidase; MAP, microtubule-associated protein; MH, MAP1 homology; HC, heavy chain; LC, light chain; SDS-PAGE, SDS-polyacrylamide gel electrophoresisMicrotubule-associated protein; Multimeric protein complex; Protein–protein interaction
Powered by pairing: The surrogate light chain amplifies immunoglobulin heavy chain signaling and pre-selects the antibody repertoire
Keywords: LC، زنجیره سبک; μHC, μ heavy chain; LC, light chain; SLC, surrogate light chain; UT, unique tail; pre-BCR, pre-B cell receptor; pro-BCR, pro-B cell receptor; BiP, heavy chain binding protein; CDR, complementarity determining region; BM, bone marrow; ITAM, immunoreceptor
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
Keywords: LC، زنجیره سبک; BoNT, botulinum neurotoxin; BoNT/A, botulinum neurotoxin serotype A; BoNT/B, botulinum neurotoxin serotype B; LC, light chain; HC, heavy chain; Rmsd, rms deviation; Bioterrorism; Botulinum neurotoxin; Drug discovery; Inhibitors; Molecular dynamics; Molecu