The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling
Keywords: α-SMA, α-smooth muscle actin; BDL, bile duct ligation; β-Gal, β-galactosidase; CCN1/CYR61, cysteine-rich protein 61; ECM, extracellular matrix; HSC, hepatic stellate cell(s); LCN2, lipocalin 2; MFB, myofibroblast(s); PDGF-BB, platelet-derived growth facto