
Circumvention of P-gp and MRP2 mediated efflux of lopinavir by a histidine based dipeptide prodrug
Keywords: HAART, Highly active antiretroviral therapy; HIV, Human immunodeficiency virus; LPV, Lopinavir; PHT1, Peptide/histidine transporter; PepT1/PepT2, Peptide transporters; TEER, Transepithelial electric resistance; GlySar, Glycylsarcosine; His, Histidine; Leu