Keywords: Zinc enzyme mimic; Scorpionate ligand; Hydroxamate; LpxC; MMP; HDAC;
مقالات ISI (ترجمه نشده)
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Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents
Keywords: LpxC; Antibacterial; Gram-negative; Sulfonamide; Benzofuran;
Structure-based discovery of LpxC inhibitors
Keywords: LpxC; Escherichia coli; Klebsiella pneumonia; Pseudomonas aeruginosa; Acinetobacter baumannii; Antibacterial;
Design, synthesis and biological evaluation of LpxC inhibitors with novel hydrophilic terminus
Keywords: LpxC; CHIR-090; Kojic acid derivatives; Methylsulfone derivatives; Metabolic stability
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain
Keywords: LpxC; Protein expression; acrB; Protein purification; Inhibitor; Crystallization;
Exploring the UDP pocket of LpxC through amino acid analogs
Keywords: LpxC; Inhibitor; Antibiotic; Hydroxamate;
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC
Keywords: LpxC; Antibacterial; Gram negative; Structure based drug design; Hydroxamic acid; Pseudomonas aeruginosa; LipE; Lipophilic efficiency; Computer aided drug design
Design and synthesis of potent Gram-negative specific LpxC inhibitors
Keywords: LpxC; Gram-negative
Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold
Keywords: LpxC; Inhibitor; Antibiotic; Diphenyl-diacetylene; 1,4-Diphenyl-1,3-butadiyne; Hydroxamate
Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents
Keywords: FtsH; AAA proteins; Proteolysis; Quality control; RpoH; LpxC; LPS biosynthesis;
Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: An electronic and structural analysis
Keywords: LpxC; MESP; HD; HUMO; LUMO;
Zinc hydrolases: the mechanisms of zinc-dependent deacetylases
Keywords: Zinc hydrolase; LpxC; Carboxypeptidase; Histone deacetylase; Aminoacylase; Amidohydrolase; MshB;