Keywords: Resistin-like molecule; Macrophage; Helminth infection; T helper type 2; Toll-like Receptor 4; ABC; ATP-binding cassette transporter; ADD1; adipocyte determination and differentiation dependent factor 1; ADSF; adipocyte secreted factor; Akt (aka PKB); pro
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Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: apo; apolipoprotein; HDL; high-density lipoprotein; HNF-1α,4α; hepatocyte nuclear factor-1α,4α; LRH-1; liver receptor homolog-1; Foxa2; forkhead box A2; PAF; platelet activating factor; LXR; liver X receptor; RXR; retinoid X receptor; FXR; farnesoid X
Keywords: ASCs; adipose stromal cells; CLS; crown-like structures; COX-2; cyclooxygenase-2; WAT; white adipose tissue; EP receptors; E prostanoid receptors; ER; estrogen receptor; IGF-I; insulin-like growth factor-I; NF-κB; nuclear factor kB; STAT3; signal transdu
Keywords: ASBT; apical sodium dependent transporter; AKT; protein kinase B; BSEP; bile salt export protein (ABCB11); CA; cholic acid; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; CYP7B1; oxysterol 7α-hydroxylase; CYP27
Keywords: Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
Keywords: 3β-HSD; 3β-hydroxysteroid dehydrogenase; CRE; cAMP response element; CREB; cAMP regulatory element binding protein; P450scc; cholesterol side chain cleavage cytochrome P450 enzyme; ChIP; Chromatin Immunoprecipitation; EMSA; electrophoretic mobility shif
miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis
Keywords: ChIP; chromatin immunoprecipitation; CL; corpus luteal cell; CV; coefficient of variation; DMEM; Dulbecco's Modified Eagle's Medium; FBS; fetal bovine serum; FSH; follicle-stimulating hormone; GC; granulosa cell; H; healthy; EA; early atresia; PA; progres
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression
Keywords: SCH; subclinical hypothyroidism; TC; total cholesterol; LDL-c; low-density lipoprotein cholesterol; TSH; thyroid stimulating hormone; TSHR; thyroid stimulating hormone receptor; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; PCSK9; proprotein convertase
LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish
Keywords: Zebrafish; LRH-1; Phosphatidylcholine; Wnt/β-catenin signaling; Development;
miRNA and cholesterol homeostasis
Keywords: miRNA; microRNA; SREBP; sterol regulatory element-binding protein; SCAP; SREBP cleavage-activating protein; Ago; Argonaute family protein; RISC; RNA-induced-silencing-complex; Fbxw7; F-box and WD repeat domain containing 7; NAFLD; non-alcoholic fatty live
Down-regulation of MicroRNA-381 promotes cell proliferation and invasion in colon cancer through up-regulation of LRH-1
Keywords: Colon cancer; MicroRNA; miR-381; LRH-1
Research ArticleThyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis
Keywords: BA; bile acid; TSH; thyroid-stimulating hormone; TSHR; thyroid-stimulating hormone receptor; TH; thyroid hormone; TR; thyroid hormone receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; LRH-1; liver receptor homologue-1; PXR; pregnane X r
Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol
Keywords: Liver; Bile Acid; Farnesoid X Receptor; Transcriptional Regulation; Asbt; rodent apical sodium dependent bile acid transporter; CDCA; chenodeoxycholic acid; ChIP; chromatin immunoprecipitation; Cyp7a1/CYP7A1; rodent/human cholesterol 7α-hydroxylase; 1,25
Therapeutic potential of Liver Receptor Homolog-1 modulators
Keywords: Orphan nuclear receptor; NR5A2; LRH-1
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Keywords: Diagnosis; Epidemiology; Cancer Risk; Mechanisms; ALT; alanine aminotransferase; APOC3; apolipoprotein C3; ARFI; acoustic radiation force impulse elastography; AST; aspartate aminotransferase; ATF6; activating transcription factor-6; AUROC; area under the
Stem cell differentiation into steroidogenic cell lineages by NR5A family
Keywords: SF-1; steroidogenic factor-1; LRH-1; liver-specific receptor homologue-1; MSCs; mesenchymal stem cells; ES cells; embryonic stem cells; Tet-off; tetracycline-off; SF-1; Differentiation; ES cells; LRH-1; Chromatin;
Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts
Keywords: Aromatase; LRH-1; NR5A2; Breast cancer
Regulation of steroid production: Analysis of Cyp11a1 promoter
Keywords: U-CRS; upstream cAMP-responsive sequence; AdE; adrenal enhancer; AP-1/AP-2; Activator protein-1/Activator protein-2; CRE; cAMP-responsive element; CREB; cAMP-responsive element-binding protein; LBP; long terminal repeat binding protein; LRH-1; liver recep
Action mechanism of Zuo Gui Yin Decoction's promotion on estradiol production in rats during the peri-menopausal period
Keywords: P450arom; romatase P450; FSHR; follicle-stimulating hormone receptor; LRH-1; liver receptor homolog-1; ERα; estrogen receptor alpha; Zuo Gui Yin Decoction; Ovary; Estradiol; Peri-menopause; Rats;
Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation
Keywords: Nuclear receptor; Post-translational modification; SUMO; Metabolism; Inflammation; Acute phase response; Transrepression; LXR; PPAR; LRH-1; N-CoR; SMRT; GPS2
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation
Keywords: TUOXXRMLFZBSTB-UHFFFAOYSA-N; JTRRVYQZHXAOGI-UHFFFAOYSA-N; QMDSMBFIKFKGBD-MDZDMXLPSA-N; WPHVYHBQJIXGIJ-UHFFFAOYSA-N; FCSGTZIUJUNGAC-UHFFFAOYSA-N; GKTSXRHLYUJTSU-QHCPKHFHSA-N; SPFSVEKWCKWVLI-DEOSSOPVSA-N; SUHGVDRUULOBLM-ZXVVBBHZSA-N; CPEYWROBUIDLPI-UHFFFAOY
Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis
Keywords: Lipotoxicity; LRH-1; Bsep; Liver Damage; ABC; adenosine triphosphate-binding cassette; ACAT; acyl-CoA cholesterol/cholesteryl transferase; BA; bile acid; Bsep; bile salt export pump; CE; cholesteryl ester; Cyp; cytochrome P450; FC; free cholesterol; FFA
Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK–BMAL1 and LRH-1
Keywords: SHP; Circadian rhythm; CLOCK–BMAL1; LRH-1; Orphan nuclear receptor
Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible regulator of insitu steroidogenesis
Keywords: LRH-1; Breast cancer; Steroidogenesis
Reconstitution of functional nuclear receptor proteins using high pressure refolding
Keywords: Steroid receptor; Estrogen receptor; FXR; LRH-1; Orphan receptor; Nuclear receptor; Bile acid; Protein expression;
Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue
Keywords: COUP-TF1; chicken ovalbumin upstream promoter-transcription factor I; COX2; cyclooxygenase-2; CREaro; cAMP responsive element in aromatase gene; CREB1; cAMP responsive element binding protein 1; EAR-2; v-erb A related gene-2; EGF; epidermal growth factor;
Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1
Keywords: SR-BI; Liver; Bile acids; FXR; LRH-1; SHP;
Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization
Keywords: NR5A2; ff1a; LRH-1; FTF; Hedgehog; ubo; syu; yot; prox1; Twitch fiber;