
Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC–MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxo
Keywords: DAM, Heroin, diamorphine; 6OM, 6-monoacetylmorphine; MOR, Morphine; M3G, Morphine-3-glucuronide; M6G, Morphine-6-glucuronide; NAL, Naloxone; NALT, NaltrexoneHeroin; LC–MS/MS; Plasma; Validation; Pharmacokinetic