Keywords: 5-HT; Serotonin; Ach; acetylcholine; AchE; acetylcholinesterase; AChR; acetylcholine receptor; BLA; basolateral amygdala; CEA; central amygdala; ChAT; choline acetyltransferase; CNS; central nervous system; DRG; dorsal root ganglion; EPSC; excitatory post
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Keywords: BF; bifenthrin; AB; antibody; BCA; bicinchoninic acid; BW; body weight; CNS; central nervous system; COX; cyclooxygenase; IL; interleukin; mPGES; microsomal prostaglandin E synthase; Nrf2; nuclear erythroid-2 like factor-2; NF-kB; nuclear factor kappa-lig
Keywords: Autonomic nervous system; Sympathectomy; Endocrine pancreas; Insulin release; Metabolism; Alpha-2 adrenergic receptor; 4-DAMP; 4-diphenylacetoxy-N-methylpiperidine methiodide; ACh; acetylcholine; α2AR; alpha-2 adrenergic receptor; ADRA2A; alpha-2 adrener
Keywords: Pituitary; Ligand-gated receptor channels; G protein-coupled receptors; Neurotransmitters; Action potentials; Calcium signaling; Hormone secretion; ACh; acetylcholine; mAChR; muscarinic ACh receptor; nAChR; nicotinic ACh receptor; AP; action potential; AM
Keywords: Opioids; Analgesia; Adverse effects; Mechanisms; Constipation; Nausea; Vomiting; Respiratory depression; 5-HT; 5-hydroxytryptamine; 7TMRs; 7-transmembrane spanning G-protein coupled receptors; AC; adenylyl cyclase; β-arr1; β-arrestin1; β-arr2; β-arres
Keywords: ACh; acetylcholine; ANOVA; analysis of variance; CNV; contingent negative variation; DA; dopamine; FP; fixation point; mAChR; muscarinic acetylcholine receptor; MI; modulation index; MR; magnetic resonance; MS; memory-guided saccade; nAChR; nicotinic acet
Keywords: ACh; acetylcholine; B2M; beta-2-microglobuline; BDNF; brain derived neurotrophic factor; BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CarAT; carnitine acetyltransferase; ChAT; choline acetyltransferase; CO2; carbon dioxide; CT; cycle t
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AChR; acetylcholine receptors; agg; aggrecan; B2M; β2-microglobulin; BMP; bone morphogenetic protein; cAMP; cyclic adenosine monophosphate; cDNA; complementary desoxyribonucleic acid; CO2; carbon dioxide; D
Keywords: 7NI; 7-Nitroindazole; AB; angular bundle; AD; after discharge; AED; antiepileptic drugs; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; ANOVA; analysis of variance; CBr; cannabinoid receptors; DG; den
Keywords: AcCoA; acetyl-coenzyme A; ACh; acetylcholine; AChE; acetylcholinesterase; AChR; ACh receptors; AD; Alzheimer's disease; ANS; autonomic nervous system; AThCh; acetylthiocholine; BAPTA-AM; 1,2-bis-(2-aminophenoxy)ethane N,N,N,Nâ²-tetraaceticacid tetra(ac
Keywords: Aβ; amyloid beta; ACh; acetylcholine; AChE; acetylcholinesterase; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BChE; butyrylcholinesterase; Iso-OMPA; tetraisopropyl pyrophosphamide; mAChR; muscarinic acetylcholine receptor; MM
Keywords: ANOVA; analysis of variance; BESA; brain electric source analysis; Change-N1m; change-related auditory N1m; EEG; electroencephalography; fMRI; functional magnetic resonance imaging; MEG; magnetoencephalography; mAChR; muscarinic acetylcholine receptor; nA
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects
Keywords: ACh; acetylcholine; ChE; cholinesterase; GPCR; G-protein-coupled receptors; mAChR; muscarinic acetylcholine receptor; OP; organophosphate; TA; mixture of trimedoxime bromide and atropine; CIE; clathrin-independent endocytosis; CDE; clathrin-dependent endo
Muscarinic modulation of the Xenopus laevis tadpole spinal mechanosensory pathway
Keywords: mAChR; Muscarinic acetylcholine receptors; nAChR; nicotinic acetylcholine receptor; dli; dorsolateral interneuron; dlc; dorsolateral commissural interneuron; dla; dorsolateral ascending interneuron; EPSP; Excitatory postsynaptic potential; IPSP; inhibitor
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
Keywords: AChE; acetylcholinesterase; ACh; acetylcholine; BP; bispyridinium; CNS; central nervous system; 7α-nAChRs; human α7-nicotinic acetylcholine receptor(s); mAChR; muscarinic acetylcholine receptor; nAChRs; nicotinic acetylcholine receptor(s); OP; organopho
Physiological roles of CNS muscarinic receptors gained from knockout mice
Keywords: Cholinergic; Muscarinic; Mice; Knockout; Knock-out; Null mutation; CIN; cholinergic interneuron; CAMKIIα; Ca2+/calmodulin-dependent protein kinase IIα; EPSP; excitatory postsynaptic potentials; HPA; hypothalamic-pituitary-adrenocortical; MAPK; mitogen-a
Highly specific detection of muscarinic M3 receptor, G protein interaction and intracellular trafficking in human detrusor using Proximity Ligation Assay (PLA)
Keywords: BPS/IC; bladder pain syndrome/interstitial cystitis; CCV; clathrin-coated vesicles; CLSM; confocal laserscanning microscopy; EE; early endosome; FFPE; omalin- fixed paraffin-embedded; GP; G proteins; IF; immunofluorescence; IHC; immunohistochemistry; LE;
In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers
Keywords: CNS; central nervous system; mAChR; muscarinic acetylcholine receptor; MB327; 1,1â²-(propane-1,3-diyl)bis(4-tert-butylpyridinium) di(iodide); nAChR; nicotinic acetylcholine receptor; NMG; N-methylglucamine; OPC(s); organophosphorus compound(s); PAM(s); p
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154
Keywords: Positive allosteric modulator; VU0467154; Antipsychotic-like activity; Cognitive enhancement; M4 muscarinic acetylcholine receptor; MK-801; mAChR; muscarinic acetylcholine receptor; PAM; positive allosteric modulator; NMDAR; N-methyl-d-aspartate subtype o
Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor
Keywords: AChE; acetylcholinesterase; CE; collision energy; CXP; collision cell exit potential; DP; declustering potential; EP; entrance potential; ESI; electrospray ionization; FDA; Food and Drug Administration; FIA; flow injection analysis; HI-6; 1-{[(4-carbamoyl
The 5-HT3 receptor antagonist ondansetron potentiates the effects of the acetylcholinesterase inhibitor donepezil on neuronal network oscillations in the rat dorsal hippocampus
Keywords: 5-HT3 receptor; Acetylcholinesterase inhibitor; Ondansetron; Donepezil; Neuronal oscillations; Alzheimer's disease; 5-HT; 5-hydroxytryptamine (serotonin); 5-HT3receptor; 5-hydroxytryptamine 3 receptor; 5-HT6receptor; 5-5-hydroxytryptamine 6 receptor; Aβ;
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor
Keywords: ACh; acetylcholine; mAChR; muscarinic acetylcholine receptor; GPCR; G protein-coupled receptor; AD; Alzheimer's disease; PAM; positive allosteric modulator; NAM; negative allosteric modulator; TM; transmembrane domain; ECL; extracellular loop; CHO; Chin
Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease
Keywords: US-FDA; United States Food and Drugs Administration; AD; Alzheimer's disease; ACh; acetylcholine; PAM; positive allosteric modulator; mAChR; muscarinic acetylcholine receptor; AChE; acetylcholine esterase; LDC; lipid drug conjugate; NP; nanoparticle; GP
Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats
Keywords: BBB; blood-brain barrier; FS; fluorescein; mAChR; muscarinic acetylcholine receptor; SSN; superior salivatory nucleus; Cevimeline; Muscarinic acetylcholine receptor; Superior salivatory nucleus; Patch-clamp; Xerostomia;
Muscarinic acetylcholine receptor but not nicotinic acetylcholine receptor plays a role in morphine-induced behavioral sensitization in rats
Keywords: mAChR; nAChR; Morphine; Behavioral sensitization; Rat;
Retinal changes in the Tg-SwDI mouse model of Alzheimer's disease
Keywords: ACh; acetylcholine; AChR; acetylcholine receptor; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta; ChAT; choline acetyltransferase; GCL; ganglion cell layer; GFAP; glial fibrillary acidic protein; IHC; immunohistochemistry; iI
The atypical antipsychotic olanzapine disturbs depotentiation by modulating mAChRs and impairs reversal learning
Keywords: Olanzapine; Antipsychotics; Synaptic plasticity; Depotentiation; mAChR; Reversal learning;
Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory
Keywords: ACQ; acquisition; ACh; acetylcholine; DMSO; dimethyl sulfoxide; IA; inhibitory avoidance; i.c.v.; intracerebroventricular; i.p.; intraperitoneal; mTOR; mammalian Target of Rapamycin; mAChR; muscarinic acetylcholine receptors; mTORC1,2; mammalian Target of
Research PaperStrength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; ChI; cholinergic interneurons; D2R; dopamine D2 receptors; mAChR; muscarinic receptors; Oxo; oxotremorine; Quin; quinpirole; Neo; neostigmine; TorA; torsinA; Dystonia; DYT1; Dorsal striatum; Cholinergic inte
Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
Keywords: ACh; acetylcholine; AP; action potential; APV; (2R)-amino-5-phosphonovaleric acid; DHβE; dihydro-β-erythroidine; DNQX; 6,7-dinitroquinoxaline-2,3-dione; EK; potassium equilibrium potential; GABA; γ-aminobutyric acid; HM; hypoglossal motoneuron; Ih; hyp
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
mAChR-dependent decrease in proteasome activity in the gustatory cortex is necessary for novel taste learning
Keywords: Proteasome; mAChR; p70S6k; Scopolamine; Attenuation of neophobia; Gustatory cortex;
Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology
Keywords: nAChR; nicotinic acetylcholine receptor; mAChR; muscarinic acetylcholine receptor; CNS; central nervous system; PNS; peripheral nervous system; OPC(s); organophosphorus compound(s); SURFE2R; surface electronic event reader; SSM; solid supported membrane(s
Nicotinic acetylcholine receptor-mediated GABAergic inputs to cholinergic interneurons in the striosomes and the matrix compartments of the mouse striatum
Keywords: Acetylcholine; Nicotinic; Cholinergic interneuron; Striosome; Matrix; ABT-418; 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ACh; acetylcholine; AChE; acetylcholinesterase;
The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery
Keywords: Cochlea; Inner hair cells; Type I spiral ganglion neurons; Lateral olivocochlear efferents; Ion channels and transporters; Neurotransmitter receptors; Postsynaptic density; Auditory neuropathy and synaptopathy; ABR; auditory brainstem response; ACh; acety
Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias
Keywords: AAV; adeno-associated virus; ACh; acetylcholine; AIMs; abnormal involuntary movements; ANOVA; analysis of variance; LIDs; L-dopa-induced dyskinesias; ChAT; choline acetyltransferase; ChR2; channel rhodopsin 2; DAT; dopamine transporter; ERK; extracellular
Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice
Keywords: Intestinal secretion; mAChR; MAP kinase
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators
Keywords: Muscarinic receptor 1; mAChR; M1; Positive allosteric modulator (PAM);
Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice
Keywords: ALP; alkaline phosphatase; BCIP/NBT; 5-bromo-4-chloro-3-indolyphosphate/nitro blue tetrazolium chloride; BMC; bone mineral content; BMD; bone mineral density; BS/TV; relative bone surface; BV/TV; relative bone volume; CaHA; calcium hydroxyapatite; CtsK; c
Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells
Keywords: mAChR; muscarinic cholinoceptor; IEC; intestinal epithelial cell; TER; transepithelial electrical resistance; IBD; inflammatory bowel diseases; FD-4; fluorescein isothiocyanate-labeled 4kDa dextran; FBS; fetal bovine serum; IFN γ; interferon γ; MT-3; mu
Research ReportPresynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus
Keywords: ACh; acetylcholine; aCSF; artificial cerebrospinal fluid; CCh; carbachol; DMSO; dimethyl sulfoxide; EPSC; excitatory postsynaptic current; fEPSP; field excitatory postsynaptic potential; mAChR; muscarinic acetylcholine receptor; MEA; multi-electrode array
Brain-inspired method for solving fuzzy multi-criteria decision making problems (BIFMCDM)
Keywords: Brain informatics; Fuzzy sets theory; Multi criteria decision making; Simulation; Web intelligence; World Wide Wisdom Web (W4); PFC; prefrontal cortex; OFC; orbito-frontal cortex; vmPFC; ventromedial prefrontal cortex; dmPFC; dorsomedial prefrontal cortex
Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
Keywords: Organotypic skin; Fibroblast heterogeneity; Wound healing; Skin models; Skin substitutes; Tissue engineering; 3D; three-dimensional; AdSCs; adipose-derived stem cells; AP-1; activated protein-1; Blimp1; B lymphocyte-induced maturation protein-1; BP; bullo
Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury
Keywords: Epithelial barrier function; Focal adhesion kinase; mAChR; IBD;
Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice
Keywords: GCI/R; Global cerebral ischemia/reperfusion injury; ACh; Acetylcholine; mAChR; Muscarinic acetylcholine receptor; nAChR; Nicotinic acetylcholine receptor; AChE; Acetylcholinesterase; ChAT; Choline acetyl transferases; CA1; Cornu Ammonis area 1; BCCAo; Bil
Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus
Keywords: ACh; acetylcholine; ACSF; artificial cerebrospinal fluid; Atrp; atropine; BIC; bicuculline; D-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DMSO; dimethyl sulfoxide; fEPSPs; field excitatory postsynaptic potentials; HFS; high-frequency stimulation; IBI;
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DHβE; dihydro-β-erythroidine; GSK3β; glycogen synthase kinase 3β; mAChR; muscarinic acetylcholine receptor; MLA; methyllycaconitine; NMD
Distinct roles of M1 and M3 muscarinic acetylcholine receptors controlling oscillatory and non-oscillatory [Ca2+]i increase
Keywords: BSS; balanced salt solution; mAChR; muscarinic acetylcholine receptors; Ca2+ signaling; Ca2+ oscillation; Muscarinic acetylcholine receptor;
G protein-coupled receptor quantification using peptide group-specific enrichment combined with internal peptide standard reporter calibration
Keywords: 5-HT; 5-hydroxytryptamine (serotonin); ESI; electrospray ionization; GPCR; G-protein coupled receptor; IPA; isopropyl alcohol; iTRAQ®; isobaric tag for relative and absolute quantification; LC-MS; liquid chromatography-mass spectrometry; LLOD; lower
Evolution of secondary metabolites in legumes (Fabaceae)
Keywords: CG; cardiac glycoside; FC; furanocoumarin; NPAA; Non-protein amino acid; QA; Quinolizidine alkaloids; PA; Pyrrolizidine alkaloids; 5HT2 R; 5-hydroxytryptamine receptor; mAChR; muscarinic acetylcholine receptor; nAChR; nicotinic acetylcholine receptor; GAB