7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies
Keywords: G protein-coupled receptors; A1 and A2A adenosine receptor antagonists; Pyrazolo[4,3-d]pyrimidines; Dual A1/A2A adenosine receptor antagonists; Ligand–adenosine receptor modeling studiesAR, adenosine receptor; PD, Parkinson's disease; MAPK, mitogen-activa