
Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling
Keywords: ADAM-17, a disintegrin and metalloproteinase 17; PPIase, peptidyl-prolyl cis/trans isomerase; CsA, cyclosporin A; ERK, extracellular signal-regulated kinase; MAPK, mitogen activated protein kinase; MC, mesangial cells; NAC, N-acetyl cysteine; ROS, reactiv