Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors
Keywords: Tetrahydrocarbazole; pERK; pRb; MDR; MAPK; CDKs;
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Structureâactivity relationship study of novel 2-aminobenzofuran derivatives as P-glycoprotein inhibitors
Keywords: 2-Aminobenzofuran; Multidrug resistance; MDR; P-glycoprotein; P-gp; ABCB1; VVDIVTCFGFHMCM-UHFFFAOYSA-N; YISKRIBGSLFCKI-UHFFFAOYSA-N; JGWRKYGEHKPWNP-UHFFFAOYSA-N; XEHLQJGGWBPGQJ-UHFFFAOYSA-N; KXEXTQDMUJUNPJ-UHFFFAOYSA-N; LJOIMSPNCSVKOQ-UHFFFAOYSA-N; LRKBQV
Xyloglucan: A functional biomacromolecule for drug delivery applications
Keywords: XG; Tamarind seed xyloglucan; TSP; Tamarind seed polysaccharide; TKP; Tamarind kernel powder; DPI; Dry powder inhalation; DOX; Doxorubicin; PAM; Polyacrylamide; MMA; Methyl methacrylate; PMMA; Polymethyl methacrylate; EA; Ethyl acrylate; PLA; Poly(l-lacti
Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity
Keywords: paclitaxel; piperlongumine; nanoparticles; synergistic effect; 5-FU; 5-fluorouracil; C6; Coumarin-6; Cmax; maximum concentration; CD31; cluster of differentiation 31; CI; combination index; CLSM; confocal laser scanning microscopy; DL; drug loading; DMEM;
Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function
Keywords: AMPPCP; β, γ-methylene ATP; CD; circular dichroism; CU; cooperative unit; CFTR; cystic fibrosis transmembrane conductance regulator; DDM; n-dodecyl-β-d-maltopyranoside; ÎHc; calorimetric enthalpy; DLS; dynamic light scattering; DMNG; decyl maltose neo
Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities
Keywords: Anti-SCLC hybrids; β-carboline; bis(hydroxymethyl)pyrrole; indolizino[8,7-b]indole; DNA cross-linking; Topoisomerase inhibition; Ac2O; acetic anhydride; ACN; acetonitrile; CCRF-CEM; human lymphoblastic leukemia; CCRF-CEM/VBL; vinblastine-resistant CCRF-C
Integrated transcriptomic and proteomic analysis of the bile stress response in probiotic Lactobacillus salivarius LI01
Keywords: LGG; Lactobacillus rhamnosus GG; DGE; digital gene expression; iTRAQ; isobaric tags for relative and absolute quantitation; RT; room temperature; RPKM; reads per kilobase of exon model per million mapped reads; DEGs; differentially expressed genes; FDR; f
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer
Keywords: P-Glycoprotein; MDR; Cancer; Alkaloids; Pgp inhibitor;
Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells
Keywords: Cicuta virosa; MDR; K562/A02; Doxorubicin; P-Glycoprotein
Effectual detection of group B streptococci with reduced penicillin susceptibility (PRGBS) by commercially available methicillin-resistant-Staphylococcus aureus (MRSA)-selective agar
Keywords: CLSI; Clinical and Laboratory Standards Institute; CTB; ceftibuten; FOX; cefoxitin; GBS; group B Streptococcus; MDR; multi-drug resistant; MIC; minimum inhibitory concentration; MRSA; methicillin-resistant-Staphylococcus aureus; OXA; oxacillin; PBP; penic
Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity
Keywords: ABC; adenosine triphosphate binding cassette; BCRP; breast cancer resistance protein; FTC; fumitremorgin C; MDR; multidrug resistance; P-gp; P-glycoptotein; SD; standard deviation; TdT; Terminal deoxyribonucleotide Transferase; Topo; topotecan; TUNEL; Ter
Correlation of clinical, laboratory and drug susceptibility profiles in 176 patients with culture positive TBM in a tertiary neurocare centre
Keywords: CSF; Cerebrospinal fluid; ELISA; Enzyme-linked immunosorbent assay; HIV; Human immunodeficiency virus; LJ; Lowenstein-Jensen; M.tb; Mycobacterium tuberculosis; MDR; Multidrug resistance; RNTCP; Revised National TB Control Program; TB; Tuberculosis; TBM; T
MiR-106a: Promising biomarker for cancer
Keywords: MiRNAs; micro RNAs; FASTK; Fas-activated serine/threonine kinase; MAPK; mitogen-activated protein kinase; NSCLC; non-small cell lung cancer; P-gp; P-glyco-protein; MDR; multidrug resistance; ABCA1; adenosine triphosphatase-binding cassette A1; TIMP2; tiss
High prevalence of extensively drug-resistant and metallo beta-lactamase-producing clinical Acinetobacter baumannii in Iran
Keywords: Acinetobacter baumannii; XDR; MBL; MDR
Maternal-fetal transfer of indocyanine green across the perfused human placenta
Keywords: a.u.; arbitrary units; AUC; area under the concentration-time curve; CI; clearance index; FA; fetal artery; FV; fetal vein; βhCG; human chorionic gonadotropin beta; DMSO; dimethylsulfoxide; ICG; indocyanine green; MDR; multidrug resistance protein; %MFT;
Evaluation of a lens-free imager to facilitate tuberculosis diagnostics in MODS
Keywords: Tuberculosis; MODS; Multi drug resistance; MDR; Diagnostics; Microscopy; ePetri; Lens-free microscopy; Lens-free imager;
Breastdosimetry of 99mTc-balloon in complementary radiotherapy
Keywords: HDR; High Dose Rate; BBB; HDR Ir-192 balloon brachytherapy; EBT; Electronic brachytherapy; TBB; Tc-99Â m balloon brachytherapy; RT; Radiation therapy; SISCODES; Sistema Computacional de Cálculo de Dose por método Estocástico; MCNP; Monte Carlo N-Partic
Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation
Keywords: Sinapine; Doxorubicin; MCF-7/dox; P-glycoprotein; NF-κB; FGFR4; FGFR; fibroblast growth factor receptor; FRS2α; FGFR substrate protein-2α; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B
β-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function
Keywords: Multidrug resistant cancer; β-carotene; P-gp; Reversal effects; MDR; multidrug resistance; ABC; ATP-binding cassette; P-gp; P-glycoprotein; MRP1; multidrug resistance protein 1; BCRP; breast cancer resistance protein;
Pneumococcal carriage in young children after introduction of PCV13 in Hong Kong
Keywords: CDC; Centers for Disease Control and Prevention; CI; confidence interval; CIP; Childhood Immunization Programme; IPD; invasive pneumococcal disease; MCHC; Maternal and Child Health Centre; MDR; multidrug resistance; MIC; minimum inhibitory concentration;
A sirtuin activator and an anti-inflammatory molecule-multifaceted roles of adjudin and its potential applications for aging-related diseases
Keywords: Adjudin; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide; ANT; adenine nucleotide translocator; CSC; cancer stem cell; EMT; epithelial-mesenchymal transition; IDH; isocitrate dehydrogenase; AIF; apoptosis inducing factor; VEGF; vascular endothelial gr
Cell differentiation and the multiple drug resistance phenotype in human erythroleukemic cells
Keywords: Leukemia; MDR; Alox-5; Differentiation; Tumoral stem cell; PMA
PXR variants: the impact on drug metabolism and therapeutic responses
Keywords: AF; activating function; BAMCA; bacterial artificial chromosome array-based methylated CpG island amplification; CYP; cytochrome P450; GST; glutathione S-transferase; MDR; multidrug resistance protein; NHR; nuclear hormone receptor; P-gp; P-glycoprotein
Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update
Keywords: Tuberculosis; MDR; XDR; Pyrazinamide; Drug resistance
Antimycobacterial activity of methanolic plant extract of Artemisia capillaris containing ursolic acid and hydroquinone against Mycobacterium tuberculosis
Keywords: Artemisia capillaris; Mycobacterium tuberculosis; Ursolic acid; Hydroquinone; MDR; XDR
Research paperIncreased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4
Keywords: MDR; multidrug resistance; FUTs; fucosyltransferases; miRNAs; microRNAs; 3â²-UTRs; 3â²-untranslated regions; GDP-Fuc; guanosine diphosphate β-l-fucose; 5-Fu; fluorouracil; PNGaseF; enzyme peptide:N-glycosidase F enzyme; HLB; hydrophilic-lipophilic bala
Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3
Keywords: Cyclosporine A; EGFR–TKI; Lung cancer; STAT3NSCLC, non-small cell lung cancer; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; STAT3, signal transducer and activator of transcription 3; CsA, cyclosporine A; CypA, cyclophilin A; MDR
Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma
Keywords: ACP; anti-cancer peptide; AML; acute myeloid leukemia; DMSO; dimethyl sulfoxide; HMEC; human mammary epithelial cell; IP; intraperitoneal; LDH; lactate dehydrogenase; LUV; large unilamellar vesicle; MDR; multidrug-resistance; PBMC; peripheral blood mononu
MDR1 mediated chemoresistance: BMI1 and TIP60 in action
Keywords: BMI1; MDR; TIP60; Chemoresistance;
Research ArticleProtein-protein interaction and molecular dynamics analysis for identification of novel inhibitors in Burkholderia cepacia GG4
Keywords: B. cepacia GG4; Burkholderia cepacia GG4; PPI; protein-protein interaction; MDR; multiple drugs resistance; NadE; NH (3)-dependent NAD synthetase; Molecular dynamics; Ortholog mapping; Multiple-drug resistance; NadE; B. cepacia;
Developing a data element repository to support EHR-driven phenotype algorithm authoring and execution
Keywords: QDM; Quality Data Model; EHR; electronic health record; eCQMs; electronic clinical quality measures; HQMF; Health Quality Measures Format; DER; data element repository; FHIR; Fast Healthcare Interoperability Resources; CIMI; Clinical Information Modeling
Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding
Keywords: AMP; antimicrobial peptide; LPS; lipopolysachharide; MDR; multidrug resistance; trNOESY; Transferred Nuclear Overhauser Effect Spectroscopy; MIC; minimal inhibitory concentration; Antimicrobial peptide; Peptide modifications; Antibacterial activity; Membr
Reconstituted high density lipoprotein mediated targeted co-delivery of HZ08 and paclitaxel enhances the efficacy of paclitaxel in multidrug-resistant MCF-7 breast cancer cells
Keywords: rHDL; reconstituted high density lipoprotein; PTX; paclitaxel; MDR; multidrug resistance; HZ08; N-cyano-1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-Nâ²-octyl-2(1H)-isoquinoline-carboximidamide; NPs; nanoparticles; FBS; fetal bovine serum; S
Induction of multixenobiotic defense mechanisms in resistant Daphnia magna clones as a general cellular response to stress
Keywords: Hsp70; Induction; P-glycoprotein; MDR; Daphnia magna
Association and multiple interaction analysis among five XRCC1 polymorphic variants in modulating lung cancer risk in North Indian population
Keywords: LC; lung cancer; SQCC; squamous cell carcinoma; ADCC; adenocarcinoma; SCLC; small cell lung carcinoma; OR; odds ratio; 95% CI; 95% confidence interval; PY; pack years; SD; standard deviation; CVC; cross validation consistency; MDR; multi-dimensionality re
Antimitotic activity of the pyrimidinone derivative py-09 on sea urchin embryonic development
Keywords: a.u.; arbitrary unit; FSW; filtered seawater; MDR; multidrug resistance; MXR; multixenobiotic resistance; REV205; reversin 205; VP; verapamil; VB; vinblastine; Antimitotic; Antiproliferative; Pyrimidinone derivative; Sea urchin; Embryonic development; Emb
Multi-locus variable number tandem repeat analysis of Vibrio cholerae isolates from 2012 to 2013 cholera outbreaks in Iran
Keywords: Vibrio cholerae; MLVA; MDR;
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB
Keywords: Tuberculosis; DNA GyrB inhibitor; MDR; XDR;
PLGA-based nanoparticles: A new paradigm in biomedical applications
Keywords: Biodegradable; Poly(lactic-co-glycolic acid); Nanoparticles; Targeting; Sustained release; DCC; N,N-Dicyclohexylcarbodiimide; DDS; Drug delivery system; DNA; Deoxyribose nucleic acid; EDC; 1-ethyl-3-(3-dimethylaminopropyl carbodiimide); EGFR; Epidermal gr
Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain
Keywords: ABCC; ATP-binding cassette; AchE; acetylcholine esterase; As; arsenic; BBB; blood brain barrier; BDNF; brain derived neuronal factor; CaM; calmodulin; CAM-K; calmodulin K; CAMKII; calmodulin-dependent protein kinase-II; CAM-II; calmodulin-II; Cd; cadmium;
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses
Keywords: CSA; cyclosporin A; DBD; drug-binding domain; DMD; defined molecular docking; EPI; epirubicin; LBE; lowest binding energy; MDA; molecular docking analysis; MDR; multidrug resistance; MFI; mean fluorescence intensity; P-gp; P-glycoprotein; R123; rhodamine
Identification of transmembrane helix 1 (TM1) surfaces important for EnvZ dimerisation and signal output
Keywords: TM1; first transmembrane helix; MDR; multidrug resistance; OM; outer membrane; SHK; sensor histidine kinase; TM2; second transmembrane helix; HAMP; domain found in histidine kinases, adenylate cyclases, MAP kinases and phosphatases; CFP; cyan fluorescent
Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis
Keywords: API; active pharmaceutical ingredient; CECs; contaminants of emerging concern; EDC; endocrine disrupting chemical; EPA; U.S. Environmental Protection Agency; EPR; extended producer responsibility; FDA; U.S. Food and Drug Administration; GS; Google Scholar
Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents
Keywords: HCC; MDR; Rhamnetin; MiR-34a; Notch-1 pathway; MDR-related proteins;
Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell
Keywords: EPAS-1; Endothelial PAS domain-containing protein 1; PXR; Pregnane X Receptor (PXR); MDR; multi-drugs resistance; CYP3A4; cytochromes P450 3A4; HIF-2α; hypoxia-inducible transcription factors; ARNT; aryl hydrocarbon receptor nuclear translocator; HRE; hy
Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms
Keywords: Isoalantolactone (Pubchem CID: 73285); Doxorubicin (Pubchem CID: 31703); Verapamil (Pubchem CID: 2520); Dofequidar (Pubchem CID: 213040); Tariquidar (Pubchem CID: 148201); 1,6-diphenyl-1,3,5-hexatriene (PubChem CID: 5376733); sodium orthovanadate (PubChem
Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation
Keywords: Primaquine; Urea; Bis-urea; Antiproliferative activity; Antioxidative activity; Antimicrobial activity; AAPH; 2,2'-azobis(2-amidinopropane) hydrochloride; BtcCl; 1-benzotriazole carboxylic acid chloride; BtH; 1H-benzo[d][1,2,3]triazole; CEM; acute lymphob
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Keywords: Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS
SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
Keywords: ACUC; Animal Care and Use Committee; AGP; andrographolide; CDK; cyclin dependent kinase; DMSO; dimethyl sulfoxide; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinases 1/2; FBS; fetal bovine serum; HPLC; high performance liquid chromatography;
Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter
Keywords: ABC-transporter; ABCG2; BCRP inhibitor; Synthesis; Structure-activity relationship; Enzyme kinetics; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein (ABCG2); CsA; cyclosporine A; FTC; fumitremorgin C; Imax; maximal inhibition; i-Pr; isop