
Decreased Sensitivity to Changes in the Concentration of Metal Ions as the Basis for the Hyperactivity of DtxR(E175K)
Keywords: DtxR, diphtheria toxin repressor; toxPO, tox promoter–operator; EMSA, electrophoretic mobility shift assay; ITC, isothermal titration calorimetryDtxR; iron-dependent regulator; protein stability; crystal structure; metal-ion binding