Keywords: متاپ; MetAP; methionine aminopeptidase; MetAMC; methionyl-7-amino-4-methylcoumarin; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; Substrate bridging; Cyclodextrin; Methionine aminopeptidase; Inhibition; Cyclodextrin-substrate complex; Molecular modeling;