Keywords: متیل گوانین متیل ترانسفراز; Recurrent malignant glioma; ATRX; Alpha thalassemia/mental retardation syndrome X-linked; Bev; Bevacizumab; CNS; Central nervous system; EGFR; Epidermal growth factor receptor; GBM; Glioblastoma multiforme; Gy; Gray; HRQoL; Health-related quality of life;