A simple, sensitive, and high-throughput LC-APCI-MS/MS method for simultaneous determination of vitamin K1, vitamin K1 2,3-epoxide in human plasma and its application to a clinical pharmacodynamic study of warfarin
Keywords: VK1; vitamin K1; VK1O; vitamin K1 2,3-epoxide; VKOR; vitamin K epoxide reductase; VKORC1; vitamin K epoxide reductase complex subunit 1; IS; internal standard; S/N; signal-to-noise ratio; GGCX; gamma-glutamyl carboxylase; Glu; glutamic acid; Gla; gamma ca