
Deficiency of metallothionein-1 and -2 genes shortens the lifespan of the 129/Sv mouse strain
Keywords: MT, metallothionein; ROS, reactive oxygen species; IIR, insulin/insulin-like growth factor-1 receptor; C. elegans, Caenorhabditis elegans; MTKO, metallothionein knockout; Mn-SOD, manganese-superoxide dismutase; PHGPx, phospholipid hydroperoxide glutathion