Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo
Keywords: پتانسیل عمل مونوفاز; DHE; dehydroevodiamine; IKr; rapid delayed rectifier current; APD; action potential duration; EAD; early afterdepolarization; cAVB; chronic atrioventricular block; TdP; Torsade de Pointes arrhythmia; hiPSC-CM; human induced pluripotent stem cell-derived c