Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene
Keywords: AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; BaP, benzo[a]pyrene; BPDE, BaP-7,8-diol-9,10-epoxide; GST, glutathione S-transferase; HPLC, high-performance liquid chromatography; MROD, methoxyresorufin-O-demethylase; PAH, polycyclic aroma