Keywords: 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge
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Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue
Keywords: ACM; Adipocyte-conditioned medium; BET; Bromodomain and extraterminal; Brd2; Bromodomain-containing protein 2; WT; Wild-type; SWI/SNF; Switch mating type/sucrose non-fermenting; Deptor; DEP domain containing mTOR-interacting protein; mTOR; Mechanistic tar
Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer
Keywords: 4E-BP-1; eukaryotic initiation factor 4E binding protein-1; ATF4; activating transcription factor 4; Bcl2; B-cell lymphoma 2; C/EBP; CAAT/enhancer binding protein; cdc-2; cyclin-dependent kinase 1 (cell division cycle protein 2); CHOP; CAAT/enhancer bindi
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer
Keywords: CCC; clear cell carcinoma; SAC; serous adenocarcinoma; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; S6K-1; ribosomal S6 kinase-1; 4E-BP1; elF4E binding protein 1; PI3K; phosphatidylinositol 3-kinase; cisplatin; cis-diaminodichloroplatinum; PT
Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway
Keywords: CS; citrate synthase; ECAR; extracellular acidification rate; FGF21; fibroblast growth factor; MELAS; mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; mtDNA; mitochondrial DNA; mTOR; mammalian target of rapamycin; mTORC; mTOR co
p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes
Keywords: 4SU; 4-thiouridine; ARVC; adult rat ventricular cardiomyocytes; CH; cardiac hypertrophy, ChIP, chromatin immunoprecipitation; ERK; extracellular ligand-regulated kinase; MEK; mitogen-activated protein kinase kinase; mTOR; mammalian target of rapamycin; mT
Research ArticleInactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways
Keywords: AKT; v-akt murine thymoma viral oncogene homolog; ERK; extracellular-related kinase; GLUT; glucose transporter; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; RPS6; ribosoma
Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors
Keywords: kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal