Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates
Keywords: ADC; antibody-drug conjugate; BINAP; 2,2â²-bis(diphenylphosphino)-1,1â²-binaphthalene; CBI; 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one; EDCI; N-ethyl-Nâ²-(3-dimethylaminopropyl)carbodiimide hydrochloride; MMAE; monomethyl auristatin E; PBD; p