Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; kidney; morphogenesis; NFAT transcription factors; etiology; organogenesisDox, doxycycline; E, embryonic day; MCDK, multicystic dysplastic kidney; MM, metanephric mesenchyme; NFAT, nuclear factor of activated T cells; P, postnatal day; rtTA, reverse tetra
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Methylation of an intragenic alternative promoter regulates transcription of GARP
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Tregs, regulatory CD4 T cells; Foxp3, forkhead box protein 3; NFAT, nuclear factor of activated T cells; TGFβ, transforming growth factor β; Th cell, T helper cell; UTR, untranslated regionTreg; GARP; DNA methylation; Gene transcription; Alternative promo
Ca2 + signal-induced cardiomyocyte hypertrophy through activation of myocardin
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; SRF, serum response factor; ANF, atrial natriuretic factor; BNP, B-type natriuretic peptide; SK-α-actin, skeletal alpha actin; ANG II, angiotensin II; IP3, inositol trisphosphate; ET-1, endothelin-1; NFAT, nuclear factor of activated T cells; CaMKII, Ca2
Anabolic steroids activate calcineurin–NFAT signaling and thereby increase myotube size and reduce denervation atrophy
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; AR, androgen receptor; RCAN, regulator of calcineurin; MCIP, modulatory calcineurin interacting protein; NFAT, nuclear factor of activated T cells; MEF2, myocyte enhance factor 2Muscle atrophy; Myotubes; Androgens; Denervation; Calcineurin–NFAT signaling
MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Osx, Osterix; 3′ UTR, 3′ untranslated region; miRNA, microRNA; BMP, bone morphogenetic protein; Cbfa-1, core-binding factor a1; OC, osteocalcin; XBP1, X-box binding protein 1; NFAT, nuclear factor of activated T cells; ALP, alkaline phosphatase; ARS, Aliz
Current Status of Immunosuppression in Liver Transplantation
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; liver transplantation; immunosuppression; metabolic syndromeHLA, human leukocyte antigen; MAP, mitogen activated protein; NF-kB, nuclear factor kappa B; IL-2, interleukin-2; CNI, Calcineurin inhibitor; NFAT, nuclear factor of activated T cells; FKBP12, FK
From gut to kidney: Transporting and metabolizing calcineurin-inhibitors in solid organ transplantation
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; CNI, calcineurin-inihibitors; CsA, cyclosporine A; CNIT, CNI related nephrotoxicity; CN, calcineurin; NFAT, nuclear factor of activated T cells; Vd, volume of distribution; AUC, area under the concentration curve; BCS, Biopharmaceutics Classification Syst
Rare sugar d-allose strongly induces thioredoxin-interacting protein and inhibits osteoclast differentiation in Raw264 cells
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; AP-1, activator protein 1; DMEM, Dulbecco modified Eagle medium; FBS, fetal bovine serum; MEM, minimum essential medium; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor-κB; PBS, phosphate-buffered saline; RANKL, receptor activator of nucl
Short-term immunological effects of non-ethanolic short-chain alcohols
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; NFAT, nuclear factor of activated T cells; AP-1, activator protein-1; NF-κB, nuclear factor-κB; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; TLR4, Toll-like receptor 4; TCR, T-cell receptor; APC, antigen-presenting c
Down-regulation of interleukin-2 production by CD4+ T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; NFAT, nuclear factor of activated T cells; PD-1, programmed death-1; PI3K, phosphatidylinositol 3-kinase; PMA, phorbol myristate acetate; SD, standard deviation; TIM-3, T cell immunoglobulin mucin domain containing molecule-3AP-1; CD4+ T cells; IL-2; NFAT
TLR7 promotes Th1 polarization in immune thrombocytopenia
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; APC, antigen-presenting cell; FBS, fetal bovine serum; GATA3, GATA-binding protein 3; GP, glycoprotein; IL, interleukin; ITP, immune thrombocytopenia; MS, multiple sclerosis; NFAT, nuclear factor of activated T cells; PBMC, peripheral blood mononuclear ce
Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Bmp, bone morphogenetic protein; CHD, congenital heart defect; Fgf, fibroblast growth factor; IP3, inositol 1, 4, 5-trisphosphate; IP3R, inositol 1, 4, 5-trisphosphate receptor; MEF, myocyte enhancer factor; NFAT, nuclear factor of activated T cells; qRT-
Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor of κ-light-chain-enhancer of activated B cells; AP-1, activator protein 1; ERK, extracellular signal-regulated kinase; PolII, RNA polymerase II; TNF, tumor necrosis factor; MIP-1α, macrophag
NFAT5 regulates transcription of the mouse telomerase reverse transcriptase gene
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; mTERT, the mouse telomerase reverse transcriptase gene; hTERT, the human telomerase reverse transcriptase gene; NFAT, nuclear factor of activated T cells; mTERT-EE, enhancer cis-element of mTERT; NFATcs, NFAT consensus sequenceTelomerase; mTERT; NFAT5; Hy
Nicotine-mediated signals modulate cell death and survival of T lymphocytes
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; FasL, Fas ligand; UV, ultraviolet; nAChR, nicotinic acetylcholine receptor; ACh, acetylcholine; Cai2+, intracellular ionized calcium; NFAT, nuclear factor of activated T cells; shRNA, small hairpin RNANicotine; Lymphocytes; Acetylcholine receptors; Calciu
The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; AKAP, A-kinase anchor protein; DMEM, Dulbecco's Modified Eagle's Medium; GFP, green fluorescent protein; MCIP1, myocyte-enriched calcineurin-interacting protein 1; MOI, multiplicity of infection; NFAT, nuclear factor of activated T cells; shRNA, small hai
FcɛRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; FcɛRI, high affinity IgE Fc receptor; RBL-2H3, rat basophilic leukemia cell line; GFP, green fluorescence protein; NFAT, nuclear factor of activated T cells; ITAM, immunoreceptor tyrosine-based activation motifs; PI 3Kinase, phosphatidylinositol 3-kinase;
NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; NFAT, Nuclear factor of activated T cells; HDAC, Histone deacetylase; OC, osteocalcin; ALP, alkaline phosphatase; TCF/LEF, T-cell factor/lymphoid enhancer-binding factorNFATc1; HDAC3; Osteoblast; Osteocalcin; TCF/LEF
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-γ expression
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; AP-1, activator protein-1; BGFI, bioactivity-guided fractionation and isolation; IFN-γ, interferon gamma; NFAT, nuclear factor of activated T cells; NFκB, nuclear factor-κB; PHA, phytohemagglutinin; T-bet, T-box expressed in T cells; TCR, T cell receptorC
RANKL-stimulated TNFα production in osteoclast precursor cells promotes osteoclastogenesis by modulating RANK signaling pathways
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; TNFα; RANKL; Osteoclastogenesis; NFATc1; c-FosTNFα, tumor necrosis factor α; RANKL, receptor activator of NF-κB ligand; NFAT, nuclear factor of activated T cells; AP-1, activator protein-1; NF-κB, nuclear factor κB
Activation of peroxisome proliferator-activated receptor-α prevents glycogen synthase 3β phosphorylation and inhibits cardiac hypertrophy
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; PPAR-α, peroxisome proliferator-activated receptor-α; PI3K, phosphoinositide 3-kinase; GSK, glycogen synthase kinase; Akt, protein kinase B; NFAT, nuclear factor of activated T cells; Ser, serine; FGF, fibroblast growth factor; VEGF, vascular endothelial
A new calcineurin inhibition domain in Cabin1
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Cabin1, calcineurin-binding protein-1; CN, calcineurin; MEF2, myocyte enhancer factor-2; NFAT, nuclear factor of activated T cells; IL-2, interleukin-2; TCR, T cell receptor; Cabin1ΔC, C-terminal Cabin1-truncated mutantCalcineurin; Cabin1; Nuclear factor
Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; MCAO, Middle cerebral artery occlusion; GPCRs, G-protein-coupled receptors; GRKs, G-protein-coupled receptor kinases; NFAT, Nuclear factor of activated T cells; NFATc4, nuclear factor of activated T-cells isoform 4; DAG, diacylglycerol; LIM domain, Lin-11
Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Ag, antigen; APC, antigen-presenting cell; CTLA-4, cytotoxic T-lymphocyte-associated antigen-4; IL, interleukin; LAT, linker of activated T cells; MHC, major histocompatibility complex; NFAT, nuclear factor of activated T cells; NFκB, nuclear factor κB; P
Differential regulation of p65 and c-Rel NF-κB transactivating activity by Cot, protein kinase C ζ and NIK protein kinases in CD3/CD28 activated T cells
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; DBD, DNA binding domain; FBS, fetal bovine serum; HA, hemagglutinin; IKK, IκB kinase; MAPK, mitogen activated protein kinase; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor κB; PKC, protein kinase C; TAD, transactivation domain; TNF, tum
Cot/Tpl2 and PKCζ cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; Cn, calcineurin; CsA, cyclosporin A; Io, A23187 calcium ionophore; FBS, fetal bovine serum; HA, hemagglutinin; Luc, luciferase; MAPK, mitogen-activated protein kinase; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor κB; PKC, protein kinas
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D2
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; PGD2, prostaglandin D2; CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells (also named DP2); DP1, D prostanoid receptor 1; PI3K, phosphatidylinositol 3-kinase; NFAT, nuclear factor of activated T cells; GSK3β, glycogen synthase kin
The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; AEA, anandamide; CB, cannabinoid receptor; COX, cyclooxygenase; FAAH, fatty acid amide hydrolase; JNK, Jun N terminal kinase; NADA, N-arachydonoildopamine; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor of kappa B; PPAR, peroxisome proli
Calcium-dependent expression of TNF-α in neural cells is mediated by the calcineurin/NFAT pathway
Keywords: NFAT، عامل هسته ای سلول های T فعال شده است; CN, calcineurin; CsA, cyclosporin A; CRE, cAMP response element; NFAT, nuclear factor of activated T cells; AP-1, activator protein-1; NF-κB, nuclear factor-κB; CREB, CRE binding protein; EMSA, electrophoretic mobility shift assay; PMA, phorbol 12-myrista