Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; DSB, double-strand break; FBS, foetal bovine serum; HR, homologous recombination; IR, ionising radiation; NHEJ, non-homologous end joining; PPARγ, peroxisome p
مقالات ISI NHEJ، پیوستن به انتهای غیر همولوگ (ترجمه نشده)
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A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; BER, base excision repair; DDG, Gibbs free energy change; GO, gene ontology; LIG3, ligase III; NER, nucleotide excision repair; NHEJ, non-homologous end joining; nsSNPs, non-synonymous single nucleotide polymorphisms; PDB, Protein Data Bank; RI, reliabili
Zinc finger nuclease technology: Advances and obstacles in modelling and treating genetic disorders
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; ZFN, Zinc finger nuclease; DSB, double-strand break; TFIII, transcription factor III; NHEJ, non-homologous end joining; TF, transcription factor; HDR, homology directed repair; HR, homologous recombination; XSCID, human X-linked sever combined immunodefic
Targeted gene mutation in tetraploid potato through transient TALEN expression in protoplasts
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; SDM, site-directed mutagenesis; DSB, double strand break; HR, homologous recombination; NHEJ, non-homologous end joining; TALEN, transcription activator-like effector nuclease; ALS, acetolactate synthasePotato; Site-directed mutagenesis; TALEN; Gene editi
Novel characteristics of CtIP at damage-induced foci following the initiation of DNA end resection
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DNA double strand break repair; DNA end resection; CtIP; PhosphorylationHR, homologous recombination; NHEJ, non-homologous end joining; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia mutated and Rad3 related; DSB, double strand break; SSD,
Loeys–Dietz syndrome type 4, caused by chromothripsis, involving the TGFB2 gene
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; TGF-β, transforming growth factor-beta; CCR, complex chromosomal rearrangements; NAHR, non-allelic homologous recombination; NHEJ, non-homologous end joining; FoSTeS, fork stalling and template switching; MMBIR, micro-homology mediated break-induced repli
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DMBA, 7,12-dimethylbenz[a]anthracene; DDR, DNA damage response; DSBs, double-strand breaks; NHEJ, Non-Homologous End Joining; HR, Homologous Recombination; TLR, Toll like receptor; Cyp, cytochromes p450; IGF, insulin growth factor; PI3K, phosphatidylinosi
CRISPR/Cas9 mediated genome engineering in Drosophila
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; CRISPR, clustered regularly interspaced palindromic repeats; Cas, CRISPR associated; DSB, double strand break; NHEJ, non-homologous end joining; HR, homologous recombinationDrosophila melanogaster; CRISPR; Cas9; Genome engineering; Targeted mutagenesis; R
Uniparental disomy analysis in trios using genome-wide SNP array and whole-genome sequencing data imply segmental uniparental isodisomy in general populations
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSBs, double strand breaks; HR, homologous recombination; NHEJ, non-homologous end joining; UPD, uniparental disomy; hUPD, uniparental heterodisomy; iUPD, uniparental isodisomy; NGS, next-generation sequencing; WGS, whole-genome sequencing; LCLs, lymphobl
Transposable elements and human cancer: A causal relationship?
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; HERVs, human endogenous retroviruses; LINE, long interspersed nuclear element; LTR, Long terminal repeats; MITEs, miniature inverted-repeat transposable elements; NHEJ, non-homologous end joining; SINE, short interspersed nuclear element; SVA, SINE-VNTR-A
The distribution of recombination repair genes is linked to information content in bacteria
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; UV, ultraviolet; GC, guanine/cytosine; AT, adenine/thymine; NHEJ, non-homologous end joining; IMG, Integrated Microbial Genomes; NCBI, National Center for Biotechnology Information; LGT, lateral gene transferProteomic constraint; Proteome size; Recombinat
DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSBs, double-strand breaks; NHEJ, non-homologous end joining; HR, homologous recombination; ENU, N-ethyl-N-nitrosourea; RIC, radiation induced curly tailed; DNA-PKcs, DNA dependent protein kinase catalytic subunit; ATM, ataxia telangiectasia mutated; ATR,
A new mechanism to ensure integration during LINE retrotransposition: A suggestion from analyses of the 5′ extra nucleotides
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; ATM, ataxia-telangiectasia mutated; bp, base pair; DSB, DNA double-strand break; kbp, kilo base pair; LINE, long interspersed element; mRNA, messenger RNA; NHEJ, non-homologous end joining; ORF, open reading frame; RT, reverse transcriptase; TPRT, target-
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSBs, DNA double strand breaks; NHEJ, non-homologous end joining; HR, homologous recombination; MRX/N, Mre11-Rad50-Xrs2/Nbs1; Mt-Ku, Ku homolog from Mycobacterium tuberculosis; CHO, Chinese hamster ovary; Ku DKO, Ku70/80 double knock-out mouse embryonic f
Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; CSMMs, closely spaced multiple mutations; FoSTeS, fork stalling and template switching; MMBIR, microhomology-mediated break-induced replication; NHEJ, non-homologous end joining; SRS, serial replication slippageChromothripsis; Complex genomic rearrangemen
BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; AML, acute myeloid leukaemia; CML, chronic myeloid leukaemia; DSBs, double strand breaks; NFκB, nuclear factor kappa B; PTK, protein tyrosine kinase; TiO2, titanium dioxide; NHEJ, non-homologous end joining; HR, homologous recombination; SSA, single-stran
Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DNA DSB repair; NHEJ; HR; SSA; I-Sce I; ZebrafishDSB, double-strand break; EGFP, enhanced green fluorescent protein; HR, homologous recombination; NHEJ, non-homologous end joining; SSA, single-strand annealing; qPCR, quantitative real-time polymerase chai
The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DDR, DNA damage response; SSA, single-strand annealing; DSB, double-strand break; BIR, break-induced replication; HR, homologous recombination; ssDNA, single-stranded DNA; NHEJ, non-homologous end joining; SDSA, synthesis-dependent strand annealing; TLS,
Common fragile sites in colon cancer cell lines: Role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; CFS, common fragile sites; APC, aphidicolin; DSBs, double strand breaks; HR, homologous recombination; NHEJ, non-homologous end joining; MMR, mismatch repair system; PARP-1, poly(ADP-ribose) polymerase-1; TMZ, temozolomide; siRNA, short interfering RNA; γ
Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; BER, base excision repair; BRCT, breast cancer susceptibility gene 1 C-terminal; dRP, 5′-deoxyribose phosphate; LP, long patch; NHEJ, non-homologous end joining; PCNA, proliferating cell nuclear antigen; Pol β, DNA polymerase beta; Pol δ, DNA polymerase d
The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cells
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; ROS, reactive oxygen species; AP sites, abasic (apurinic/apyrimidinic) sites; DSB, double strand break; NHEJ, non-homologous end joining; BER, base excision repair; SSB, single strand break; MS, mitosox red; SOSG, singlet oxygen sensor green; ARP, aldehyd
Spatiotemporal analysis of DNA repair using charged particle radiation
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; RIF, radiation-induced foci; DSB, double-strand break; LET, linear energy transfer (typical unit: keV/μm); HZE, ions with high energy and high atomic number; Amu, atomic mass units; NHEJ, Non-Homologous End Joining; HR, Homologous Recombination; DDR, DNA
Fine tuning chemotherapy to match BRCA1 status
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DDR, DNA damage response; DSB, double stranded break; HR, homologous recombination; NER, nucleotide excision repair; NHEJ, non-homologous end joining; NSCLC, non-small cell lung carcinoma; PARP, poly ADP ribose polymerase; siRNA, small interfering RNA; SS
Radiation induced DNA DSBs: Contribution from stalled replication forks?
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; BER, base excision repair; NHEJ, non-homologous end joining; HR, homologous recombination; LET, linear energy transfer; PARP, poly(ADP ribose) polymerase; MEM, minimal essential medium; PBS, phosphate buffered saline; DSB, double strand break; SSB, single
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-PK catalytic subunit; ds, double-stranded; DSB, DNA double strand break; IR, ionizing radiation; NHEJ, non-homologous end joining; ss, single-stranded; SAXS, small angle X-ray scattering; XLF, XRCC4 like
Effects of DNA damage induced by UV irradiation on gene expression in the protozoan parasite Entamoeba histolytica
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; UV, ultraviolet light; DSB, double strand breaks; HR, homologous recombination; NHEJ, non-homologous end joining; ORF, open reading frameEntamoeba histolytica; Amoebiasis; DNA damage repair; Double strand breaks; cDNA microarrays
Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; ds, double stranded; DSB, double stranded breaks; GT, gene targeting; GTR, gene targeting ratio; HR, homologous recombination; NHEJ, non-homologous end joining; NHI, non-homologous DNA integration; ss, single stranded; SDSA, synthesis-dependent strand-ann
The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DIV, days in vitro; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; shRNA, short-hairpin RNA; EGFP, enhanced green fluorescent protein; NHEJ, non-homologous end joining; RFP, red fluorescent protein; MAP2, m
Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; BSO, buthionine sulfoximine; BER, base excision repair; HR, homologous recombination; NHEJ, non-homologous end joining; 4-NQO, 4-nitroquinoline 1-oxide; RPE, retinal pigment epithelium; WS, Werner syndrome; GSH, reduced glutathione; MMS, methyl methane-su
Functional analysis of Drosophila melanogaster BRCA2 in DNA repair
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; HR, homologous recombination; IR, ionising radiation; Gy, gray; DSBR, double-strand break repair; NHEJ, non-homologous end joining; dsRNA, double-stranded RNA; KD, knock-down; HU, hydroxyurea; MMS, methyl methanesulfonateBRCA2; DNA repair; DNA damage; Gen
Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSB, double-stranded break; HR, homologous recombination; NHEJ, non-homologous end joining; PARP, poly (ADP-ribose) polymerase; RIP, replication-initiated processing; tAML, therapy-related secondary acute myeloid leukemia; TIP, transcription-initiated pro
Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II — Induced chromosomal rearrangements
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; topoII, DNA topoisomerase II; DSB, DNA double-strand break; NHEJ, non-homologous end joining; bcr, breakpoint cluster region; MAR, matrix association region; ChIP, chromatin immunoprecipitation; VP16, etoposide.AML1/RUNX1 gene; Breakpoint cluster region;
RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; AML, acute myeloid leukaemia; DSB, double strand break; HR, homologous recombination; NHEJ, non-homologous end joining; FA, Fanconi's anemia; OR, odds ratio; CI, confidence intervalAcute myeloid leukaemia; DNA repair; Double strand break; Homologous recom
Initiation of V(D)J recombination in zebrafish (Danio rerio) ovaries
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; CEs, coding ends; CJs, coding joints; DSBs, double-strand DNA breaks; LM-PCR, Ligation-mediated PCR; NHEJ, Non-homologous end joining; SEs, signal ends; SJs, signal jointsGermline gene rearrangement; Ligation-mediated PCR; Non-homologous end joining; Reco
Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; HRDC, Helicase and RNase D C-terminal; DrRecQ, Deinococcus radiodurans RecQ; EcSSB, E. coli single strand binding protein; DrSSB, D. radiodurans single strand binding protein; NHEJ, non-homologous end joining; ssDNA, single-stranded DNA; dsDNA, double-str
Enhanced repair of DNA interstrand crosslinks in S phase
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSB, double strand breaks; ICL, interstrand crosslink; HR, homologous recombination; NHEJ, non-homologous end joining; TE, 10 mM Tris, 1 mM EDTA, pH 7DNA interstrand crosslink; Trioxsalen; Repair; Recombination; Nuclear matrix; Cell cycle
DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; NHEJ, non-homologous end joining; DSB, double strand breaks; HR, homologous recombination; BER, base excision repairDNA double strand breaks; DNA repair; NHEJ; Rat brain; Neurons; Aging
Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; V(D)J recombination; Signal joints; Junctional diversity; T-cell receptor; ThymocytesArt, Artemis; CE, Coding end; CJ, Coding joint; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-PK catalytic subunit; NHEJ, Non-homologous end joining; RSS, Recombina
CeBRC-2 Stimulates D-loop Formation by RAD-51 and Promotes DNA Single-strand Annealing
Keywords: NHEJ، پیوستن به انتهای غیر همولوگ; DSB, DNA double-strand break; NHEJ, non-homologous end joining; SSA, single-strand annealing; HR, homologous recombination; ssDNA, single-stranded DNA; dsDNA, double-stranded DNA; OB, oligonucleotide/oligosaccharide-binding; WT, wild-typeBRCA2; RAD51; rep