
An LC-MS/MS method for quantification of AC0010, a novel mutant-selective epidermal growth factor receptor (EGFR) inhibitor, and its metabolites in human plasma and the application to a pharmacokinetic study
Keywords: سرطان ریه غیر سلولی کوچک; DMSO; dimethyl sulphoxide; EGFR-TKI; epidermal growth factor receptor tyrosine kinase inhibitor; NSCLC; non-small-cell lung cancer; SPE; solid-phase extraction; AC0010; EGFR TKI; Non-small-cell lung cancer; LC-MS/MS; Method validation; Pharmacokinetics;